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TNF, LT and IL-1 natural inhibitors (soluble receptors and receptor antagonists) in women with ovarian cancer

  • G. Granger
  • T. Gatanaga
  • R. Burger
  • E. Grosen
  • M. Berman
  • R. DiSaia

Abstract

Cell mediated immunity (CMI) is an important element of host antitumor resistance mechanisms. Tumor necrosis factor (TNF), lymphotoxin (LT) and interleukin-1 (IL-1) are key cytokines used by host effector lymphoid cells to orchestrate recognition, tissue destructive and inflammatory phases of these important reactions [1–4]. These molecules have multiple effects on cells in vitro and tissues in vivo. Some of these effects which are important for tumor regression are:
  1. 1.

    Cytolysis of certain transformed cells

     
  2. 2.

    Destruction of tumor blood vessels

     
  3. 3.

    Upregulation of surface proteins making tumor cells more immunogenic

     
  4. 4.

    Induce, recruit and activate host lymphoid cells to express antitumor activity

     
  5. 5.

    Induce inflammation

     
  6. 6.

    Leukocytosis [1–4].

     

Keywords

Ovarian Cancer Tumor Necrosis Factor Natural Inhibitor Ascites Cell Human Tumor Necrosis Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • G. Granger
  • T. Gatanaga
  • R. Burger
  • E. Grosen
  • M. Berman
  • R. DiSaia

There are no affiliations available

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