Cell growth regulation in ovarian cancer: tyrosine kinases, tyrosine phosphatases and tumour necrosis factor-α

  • R. C. BastJr
  • J. Wiener
  • S. Kassim
  • S. Wu
  • C. M. Boyer
  • K. De Sombre
  • J. A. Hurteau
  • G. Rodriguez
  • G. B. Mills
  • A. Berchuck


Since the last Helene Harris Symposium two years ago, epithelial ovarian cancer has been shown to be a clonal disease [1,2]. Consequently, multiple genetic changes within a single cell are thought to be required for malignant transformation. Such events are most likely to occur during the proliferation of surface epithelial cells to repair defects created by ovulation. Growth regulation of the normal surface epithelium is tightly controlled by several known growth factors [3].


Ovarian Cancer Epithelial Ovarian Cancer Epidermal Growth Factor Receptor Expression Surface Epithelial Cell Tyrosine Kinase Growth Factor Receptor 
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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • R. C. BastJr
  • J. Wiener
  • S. Kassim
  • S. Wu
  • C. M. Boyer
  • K. De Sombre
  • J. A. Hurteau
  • G. Rodriguez
  • G. B. Mills
  • A. Berchuck

There are no affiliations available

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