The sulfhydryl and disulfide groups of proteins belong respectively to the residues of cysteine and cystine. Cystine was first discovered by Wollaston (1810) in stones of the bladder, whence it obtained its name.* Only many years later was it found in proteins (Mörner, 1899) and its structure established (Neuberg, 1902; Friedmann, 1903). In 1907 Heffter (1907) discovered SH groups in proteins, but only the discovery of glutathione and the study of its role (Hopkins, 1921) excited wide interest in the investigation of SH groups.
KeywordsSuccinate Dehydrogenase Lipoic Acid Oxidize Glutathione Thiol Reagent Disulfide Group
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