Abstract
As part of the diff3 System, the diff3 analyzer represents a practical application of real-time image processing to an important clinical need, automation of blood-smear analysis. To accomplish this task, the analyzer is supported by a complete complement of sample preparation reagents and instrumentation, including an Ames Company stainer and a proprietary diluter/spinner; design details for the latter are available [Maher and Pirc (1977a, 1977b, 1978)]. The sample preparation methodology has been evaluated by Nourbakhsh et al. (1978); it produces Wright’s stained blood smears, on standard microscope slides, which are of consistently high uniformity and quality (Color Plates 21 and 22).*
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brenner, J. F., Gelsema, E. S., Necheles, P. W., Neurath, P. W., Selles, W. D., and Vastola, E., “Automated Classification of Normal and Abnormal Leukocytes,” J. Histochem. Cytochem. 22:697 (1974).
Gilmer, P. R., “The Coulter Perkin-Elmer diff3 Automated Counting System,” in Differential Leukocyte Counting (Koepke, J. A., ed.) College of American Pathologists, p.135 (1978).
Green, J. E., “A Practical Application of Computer Pattern Recognition Research — The Abbott ADC-500 Differential Counter,” J. Histochem. Cytochem. 27:160 (1979).
Golay, M. J. E., “Hexagonal Parallel Pattern Transformations,” IEEE Trans. Comput. C-18:733 (1969).
Golay, M. J. E., “Analysis of Images,” U.S. Patent 4,060,713, November 29 (1977).
Ingram, M., Norgren, P. E., and Preston, K., Jr., “Automatic Differentiation of White Blood Cells,” in Image Processing in Biological Science (Ramsey, D. M., ed.) Univ. of Calif. Press p.97 (1968).
Kulkarni, A. V., “Effectiveness of Feature Groups for Automated Pairwise Leukocyte Class Discrimination,” J. Histochem. Cytochem. 27:210 (1979).
Maher, F. W., and Pirc, V. V., “Method for Blood Film Preparation,” U.S. Patent 4,037,003, July 19 (1977a).
Maher, F. W., and Pirc, V. V., “Apparatus for Blood Film Preparation,” U.S. Patent 4,016,828, April 12 (1977b).
Maher, F. W., and Pirc, V. V., “Diluting and Dispensing Probe for Blood Sample Preparation,” U.S. Patent 4,108,608, August 22 (1978).
Megla, G. K., “The LARC Automatic White Blood Cell Analyzer,” Acta Cytol. 17:3 (1973).
Miller, M. N., “Design and Clinical Results of Hematrak: an Automated Differential Counter,” IEEE Trans. Biomed. Eng.
Norgren, P. E., Kulkarni, A. V., and Graham, M. D., “Leukocyte Image Analysis in the diff3 System,” submitted to Pattern Recog. (1980).
Nosanchuk, J. S., Dawes, P., Kelly, A., and Heckler, C., “An Automated Blood Smear Analysis System,” Am. J. Clin. Pathol. 73:165 (1980).
Nourbakhsh, M., Atwood, J. G., Raccio, J., and Seligson, D., “An Evaluation of Blood Smears Made by a New Method Using a Spinner and Diluted Blood,” Am. J. Clin. Pathol. 70:885 (1978).
Preston, K., Jr., “Feature Extraction by Golay Hexagonal Pattern Transforms,” IEEE Trans. Comput. C-20:1007 (1971).
Preston, K., Jr., and Norgren, P. E., “Interactive Image Processor Speeds Pattern Recognition by Computer,” Electronics 45:89 (1972).
Preston, K., Jr., Duff, M. J. B., Levialdi, S., Norgren, P. E., and Toriwaki, J.-I., “Basics of Cellular Logic with Some Applications in Medical Image Processing,” Proc. IEEE 67:826 (1979).
Preston, K., Jr., “Automation of the Analysis of Cell Images,” Anal. Quant. Cytol. 2:1 (1980).
Schoentag, R. A., and Pedersen, J. T., “Evaluation of an Automated Blood Smear Analyzer,” Am. J. Clin. Pathol. 71:685 (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Graham, M.D., Norgren, P.E. (1980). The diff3T.M. Analyzer: A Parallel/Serial Golay Image Processor. In: Onoe, M., Preston, K., Rosenfeld, A. (eds) Real-Time Medical Image Processing. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0121-0_13
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0121-0_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0123-4
Online ISBN: 978-1-4757-0121-0
eBook Packages: Springer Book Archive