Biosynthesis of Sterols, Carotenoids, and Polyprenols
Since the demonstration that acetate is the source of carbon for cholesterol produced by rat liver tissue (Bloch, 1951) and ergosterol in fungi (Neurospora) (Ottke et al., 1950), a large volume of information concerning sterol biosynthesis has been published, and various aspects have been reviewed on several occasions (Cornforth, 1959; Wolstenholme and O’Connor, 1959; Popjak and Cornforth, 1960; Heftmann and Moseltig, 1960; Bloch, 1965; Clayton, 1965; Frantz and Schroepfer, 1967; Goad, 1967; Goodwin, 1971). Early progress (1950’s) in establishing the pathway of sterol synthesis was greatly facilitated by the availability of [14C] labeled substrates, and an understanding of the reaction mechanisms was made possible with the more recent synthesis of stereospe-cifically labeled mevalonic acid. The early studies were conducted mainly with mammalian (rat liver) and fungal (yeast and Neurospora) systems.
KeywordsCarotenoid Biosynthesis Sterol Biosynthesis Sterol Synthesis Farnesyl Pyrophosphate Ergosterol Biosynthesis
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