Negative Feedback Inhibition of Pancreatic Exocrine Secretion in Humans

  • P. P. Toskes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 199)


The evidence is quite solid that a feedback inhibition system of the pancreatic exocrine secretion exists in a number of animal species. Whether or not such a regulatory system is operative in man remains controversial. Studies in normal human subjects which have been interpreted as evidence that such a regulatory system is not present in man suffer from serious flaws in experimental design, such as the inability to completely divert pancreatic enzymes (chymotrypsin, elastase) as important principles in this control mechanism. Studies in both normal human subjects and patients with chronic pancreatitis will be reviewed.


Chronic Pancreatitis Trypsin Inhibitor Pancreatic Enzyme Pancreatic Secretion Amino Acid Solution 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • P. P. Toskes
    • 1
  1. 1.Department of MedicineUniversity of FloridaGainesvilleUSA

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