Interaction of Dietary Protein and Trypsin Inhibitor on Plasma Cholecystokinin and Pancreatic Growth in Rats

  • Gary M. Green
  • Van H. Levan
  • Rodger A. Liddle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 199)


Pancreatic exocrine secretion in the rat is inhibited by trypsin, chymotrypsin and elastase in the proximal small intestine (Green and Lyman, 1972; Schneeman and Lyman, 1973; Green and Levan, 1985). Recent studies have supported the hypothesis that this negative feedback control of pancreatic secretion is mediated by cholecystokinin (CCK). Orogastric administration of trypsin inhibitors to rats caused a transient reduction of intestinal levels of CCK (Brand and Morgan, 1981) and greatly increased plasma levels of CCK (Liddle, Goldfine and Williams, 1984). Diversion of bile-pancreatic juice from the intestine increased plasma CCK levels, which were returned to normal by intraduodenal infusion of trypsin (Louie et al, 1985; Fölsh et al, 1984). The mechanism by which pancreatic proteases inhibit CCK release is not known. Miyasaka and Green (1983) hypothesized that trypsin inhibited pancreatic secretion by inactivating an intraluminally-secreted peptide, possibly a CCK-releasing factor.


Dietary Protein Trypsin Inhibitor Pancreatic Secretion Pancreatic Enzyme Secretion Amino Acid Availability 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Gary M. Green
    • 1
  • Van H. Levan
    • 1
  • Rodger A. Liddle
    • 2
    • 3
  1. 1.Department of PhysiologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  2. 2.Cell Biology LaboratoryMt. Zion Hospital and Medical CenterSan FranciscoUSA
  3. 3.Department of MedicineUniversity of CaliforniaSan FranciscoUSA

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