Pancreatic Carcinogenesis — the Potential of Cholecystokinin as a Cocarcinogen in the Hamster — Nitrosamine Model

  • Allan G. Howatson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 199)


A number of epidemiological studies have demonstrated associations which support the concept that cancer of the exocrine pancreas in man is the result of chemical carcinogenesis. Cigarette smoking doubles the risk of developing pancreatic cancer (Kahn, 1966; Doll and Peto, 1976) and is a source of many known carcinogens (Hoffmann et al., 1982). The high fat-protein diet of Western countries has also been suggested as a factor increasing the risk of developing pancreatic cancer (Wynder, 1975; Armstrong and Doll, 1976; Hirayama, 1979).


Pancreatic Cancer Exocrine Pancreas Syrian Golden Hamster Pancreatic Carcinogenesis Ductular Proliferation 
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  1. Armstrong, B., Doll, R., 1975, Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Internatl J Cancer., 15:617–631.CrossRefGoogle Scholar
  2. Birt, D.F., Salmasi, S., Pour, P.M., 1981, Enhancement of experimental pancreatic cancer in Syrian golden hamsters by dietary fat. J Natl Cancer Inst., 67:1327–1332.Google Scholar
  3. Burton, K., 1956, A study of the conditions and mechanisms of the diphenylamine reaction for the calorimetric estimation of deoxyribonucleic acid. Biochem J., 62:315–323.Google Scholar
  4. Cubilla, A.L., Fitzgerald, P.J., 1980, Cancer (nonendocrine) of the pancreas. A suggested classification, in: “The Pancreas,” Fitzgerald, P.J., and Morrison, A.B., eds. International Academy of Pathology, Monograph No. 21, Baltimore. Williams and Wilkins., 6:82–110.Google Scholar
  5. Doll, R., Peto, R., 1976, Mortality in relation to smoking: 20 years observations on male British doctors. Br Med J., 2:1525–1536.CrossRefGoogle Scholar
  6. Farber, E., 1982, Chemical carcinogenesis: a biological perspective. Am J Path., 106:271–296.Google Scholar
  7. Fölsch, U.R., Winckler, K., Wormsley, K.G., 1974, Effect of a soybean diet on enzyme content and ultrastructure of the rat exocrine pancreas. Digestion., 11:161–171.CrossRefGoogle Scholar
  8. Gerchman, L.L., Ludlum, D.B., 1973, The properties of O6-methylguanine in templates for RNA polymerase. Biochem Biophys Acta., 308:310–316.CrossRefGoogle Scholar
  9. Giles, K.W., Myers, A., 1965, An improved diphenylamine method for the estimation of deoxyribonucleic acid. Nature., 206:93.CrossRefGoogle Scholar
  10. Harper, A.A., Scratcherd, T., 1979, Physiology. in: “The Exocrine Pancreas,” H.T. Howat, H. Sarles, eds., W.H. Saunders, Philadelphia.Google Scholar
  11. Harris, C.C., Grafstrom, R.C., Lechner, J.F., Autrup, H., 1982, Metabolism of N-nitrosamines and repair of DNA damage in cultured human tissues and cells, in: “Nitrosamines and human cancer,” P.N. Magee, ed., Cold Spring Harbour Laboratory., 122–134.Google Scholar
  12. Hirayama, T., 1979, Diet and cancer. Nutrit Cancer., 1:67–81.CrossRefGoogle Scholar
  13. Hoffmann, D., Brunnemann, K.D., Adams, J.D., Rivenson, A., Hecht, S.S., 1982, N-Nitrosamines in tobacco carcinogenesis, in: “Nitrosamines and human cancer,” P.N. Magee, ed. Cold Spring Harbour Laboratory., 211–220.Google Scholar
  14. Kahn, H.A., 1966, The Dorn study of smoking and mortality among U.S. veterans, report on eight and one-half years of observation. Natl Cancer Inst Monogr., 19:1–126.Google Scholar
  15. Margison, G.P., Margison, J.M., Montesano, R., 1976, Methylated pruines in the deoxyribonucleic acid of various Syrian golden hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine. Biochem J., 157: 627–634.Google Scholar
  16. Miller, J.A., 1970, Carcinogenesis by chemicals: An overview — G.H.A. Clowes Memorial Lecture. Cancer Res., 30:559–576.Google Scholar
  17. Morgan, R.G.H., Levinson, D.A., Hopwood, D., Saunders, J.H.B., Wormsley, K.G., 1977, Potentiation of the action of azaserine on the rat pancreas by raw soya bean flour. Cancer Lett., 3:87–90.CrossRefGoogle Scholar
  18. Munro, H.N., Fleck, A., 1966, Recent developments in the measurement of nucleic acids in biological materials. Analyst., 91:78–88.CrossRefGoogle Scholar
  19. Pegg, A.E., 1977, Formation and metabolism of alkylated nucleosides; possible role in carcinogenesis by nitroso compounds and alkylating agents. Adv Cancer Res., 25: 195–269.CrossRefGoogle Scholar
  20. Petersen, H., Solomon, T., Grossman, M.I., 1978, Effect of chronic pentagastin, cholecystokinin and secretin on pancreas of rats. Am J Physiol., 234:E286–E293.Google Scholar
  21. Pour, P., Althoff, J., Kruger, F.W., Mohr, U., 1977, A potent pancreatic carcinogen in Syrian hamster: N-nitrosobis(2-oxopropyl) amine. J Natl Cancer Inst., 58:1449–1453.Google Scholar
  22. Reznik-Schuller, H.M., Lizinsky, W., Hague, B.F., 1980, Electron microscopic autoradiography of the pancreas in the hamster treated with tritiated N-nitroso-2, 6-dimethylmorpholine. Cancer Res., 40:2245–2247.Google Scholar
  23. Roebuck, B.D., Yager, J.D., Longnecker, D.S., 1981, Dietary modulation of azaserine-induced pancreatic carcinogenesis in the rat. Cancer Res., 41:888–893.Google Scholar
  24. Scarpelli, D.G., Rao, M.S., Subbarao, V., Beversluis, M., Gurka, D.P., Hollenberg, F.F., 1980, Activation of nitrosamines to mutagens by postmitochondrial fraction of hamster pancreas. Cancer Res., 40:67–74.Google Scholar
  25. Wynder, E.L., 1975, An epidemiological evaluation of the causes of cancer of the pancreas. Cancer Res., 35:2228–2233.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Allan G. Howatson
    • 1
  1. 1.University Department of PathologyRoyal InfirmaryGlasgowScotland, UK

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