Inhibition of Human Proteinases by Grain Legumes

  • Juergen K. P. Weder
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 199)


The inhibition of proteolytic enzymes by extracts from animal tissues was already demonstrated at the end of the last century (Fredericq, 1878). But although detailed studies have been made in this field, sixty years passed until the first indication of the inhibition of a proteinase by a plant extract (aqueous extracts from soy flour inhibited the liquefaction of gelatin by trypsin) was published (Read and Haas, 1938). This was soon followed by the first isolation of a plant proteinase inhibitor from soybeans by Kunitz (1945, 1946). A year later the first systematic study of plant proteinase inhibitors was made by Borchers and Ackerson (1947). Because of the great and increasing importance of grain legumes as food and feed, research during the next period was mainly concentrated on seeds from the legume family.


Trypsin Inhibitor Lima Bean Soybean Trypsin Inhibitor Kidney Bean Trypsin Inhibitor Activity 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Juergen K. P. Weder
    • 1
  1. 1.Institut fuer LebensmittelchemieTechnische Universitaet MuenchenGarchingGermany

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