The Effect of the Long-Term Feeding of Raw Soyflour on the Pancreas of the Mouse and Hamster

  • Irvin E. Liener
  • Aharon Hasdai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 199)


The effects of the long-term feeding of mice and hamsters with raw (RSF) or heated (HSF) soy flours were investigated both in the presence and absence of chemical carcinogens. Mice which had been fed RSF for 18 months had enlarged pancreas but only a relatively low incidence of atypical acinar cell nodules (AACN). Mice on either RSF or HSF were also relatively resistant to the carcinogenic effects of azaserine which is known to produce a high incidence of AACN in rats. Hamsters which had been fed RSF for 15 months did not exhibit pancreatic enlargement and had a very low incidence of pancreatic tumors. Although the incidence of tumors in hamsters which had been injected with N-nitrosobis (2-oxopropyl) amine and maintained on HSF was very high (88%), those on RSF had a tumor incidence of less than 10%. Thus, there appears to be a marked difference in the response of the pancreas in different species of animals to the long-term effects of feeding RSF. This should be taken into consideration in evaluating the potential carcinogenicity of the trypsin inhibitors.


Trypsin Inhibitor Pancreatic Lesion Trypsin Inhibitor Activity Pancreas Weight Pancreatic Enlargement 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Irvin E. Liener
    • 1
  • Aharon Hasdai
    • 1
  1. 1.Department of Biochemistry, College of Biological SciencesUniversity of MinnesotaSt. PaulUSA

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