The Natural History of Human Breast Cancer

  • M. Tubiana
  • A. J. Valleron
  • E. Malaise


Breast carcinoma stands out for its broad spectrum of clinical behaviour, ranging from that of a highly aggressive neoplasm which disseminates shortly after diagnosis and causes death rapidly to that of a virtually chronic disease, compatible with many decades of survival even when initial therapy has failed to eradicate the cancer.


Breast Cancer Primary Tumor Breast Carcinoma Human Breast Cancer Doubling Time 
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  1. Berg, J.W., and Robbins, G.F., 1966, Factors influencing short and long term survival of breast cancer. Surg. Gynec. Obstet., 122, 1311–1316.PubMedGoogle Scholar
  2. Bloom, H.J.G., and Richardson, W.W., 1957, Histological grading and prognosis in breast cancer. A study of 1 409 cases of which 359 have been followed 15 years. Brit. J. Cancer, 11, 359–377.PubMedCrossRefGoogle Scholar
  3. Brinkley, D., and Haybittle, J.L., 1975, The curability of breast cancer. Lancet, 2, 95–97.PubMedCrossRefGoogle Scholar
  4. Charbit, A., Malaise, E., and Tubiana, M., 1971, Relation between the pathological nature and the growth rate of human tumors. Europ. J. Cancer, 7, 307–315.CrossRefGoogle Scholar
  5. Chavaudra, N., Richard, J.M., and Malaise, E.P., 1977, Labelling index of human squamous cell carcinomas. Comparison of in vivo and in vitro labelling methods. Cell Tissue Kinet., 12, 145–152.Google Scholar
  6. Contesso, G., Rouesse, J., Petit, J.Y., and Mouriesse, H., 1977, Les facteurs anatomo-pathologiques du pronostic des cancers du sein. Bull. Cancer (Paris), 64, 525–536.Google Scholar
  7. Cutler, S.J., Asire, J.A., and Taylor, S.G., 1969, Classification of patients with disseminated cancer of the breast. Cancer, 24, 861–869.PubMedCrossRefGoogle Scholar
  8. Gioanni, J., Farges, M.F., Asin, Ch., and Lalanne, C.M., 1979, L’index de marquage dans les cancers du sein et des voies aéro-digestives supêrieures. Bull. Cancer (Paris), 66, 479–484.Google Scholar
  9. Glucksmann, A., 1948, The relation of radiosensitivity and radiocurability to the histology of tumor tissue. Br. J. Radiol., 21, 559–566.PubMedCrossRefGoogle Scholar
  10. Kusama, S., Spratt, J.S., Donegan, W.L., Watson, F.R., and Cunningham, C., 1972, The gross rates of growth of human mammary carcinoma. Cancer (Philad.), 30, 594–599.CrossRefGoogle Scholar
  11. Lalanne, C.M., 1963, Taux d’accroissement et pronostic des tumeurs malignes du sein. In “Symposium on the Prognosis of Malignant Tumours of the Breast”, p. 16, Karger, Bâle.Google Scholar
  12. Malaise, E.P., Chavaudra, N., and Tubiana, M., 1973, The relationship between growth rate, labelling index and histological type of human solid tumours. Europ. J. Cancer, 9, 305–312.CrossRefGoogle Scholar
  13. Malaise, E.P., Chavaudra, N., Charbit, A., and Tubiana, M., 1974, Relationship between the growth rate of human metastases, survival and pathological type. Europ. J. Cancer, 10, 451–459.CrossRefGoogle Scholar
  14. Meyer, J.S., Bauer, W.C., and Rao, B.R., 1978, Subpopulations of breast carcinoma defined by S-phase fraction, morphology, and estrogen receptor content. Lab. Invest., 39, 225–235.PubMedGoogle Scholar
  15. Meyer, J.S., and Hixon, B., 1979, Advanced stage and early relapse of breast carcinomas associated with high Thymidine labelling indices. Cancer Research, 29, 4042–4047.Google Scholar
  16. Philippe, E., and Le Gal, Y., 1968, Growth of 78 recurrent mammary cancers. Quantitative study. Cancer (Philad.), 21, 461–467.CrossRefGoogle Scholar
  17. Poste, G., and Fider, I.J., 1980, The pathogenesis of cancer metastasis. Nature, 283, 139–146.PubMedCrossRefGoogle Scholar
  18. Rambert, P., Malaise, E., Laugier, A., Schlienger, M., and Tubiana, M., 1968, Données sur la vitesse de croissance des tumeurs humaines. Bull. Cancer (Paris), 55, 323–342.Google Scholar
  19. Richards, G.E., 1948, Mammary cancer, Part I. Brit. J. Radiol., 21; 109–127.PubMedCrossRefGoogle Scholar
  20. Rigby-Jones, P., 1963, Prognosis of malignant tumours of the breast in relation to rate of growth and axillary lymph node involvement as observed clinically. In “Symposium on the Prognosis of Malignant Tumours of the Breast”, p. 24, Karger, Bale.Google Scholar
  21. Salmon, S.E., and Durie, B.G.M., 1975, Cellular kinetics in multiple myeloma. A new approach to staging and treatment. Arch. Intern. Med., 135, 131–138.PubMedCrossRefGoogle Scholar
  22. Slack, N.H., Blumenson, L.E., and Bross, I.D.J., 1969, Therapeutic implications from a mathematical model characterizing the course of breast cancer. Cancer (Philad.), 24, 960–971.CrossRefGoogle Scholar
  23. Sommers, S.C., 1973, Growth rates, cell kinetics and mathematical models of human cancers. Pathobiology Annual, vol. 3, p. 309, Appleton-Century-Croft, New York.Google Scholar
  24. Strax, P., 1978, Evaluation of screening programs for the early diagnosis of breast cancer. Surgical Clinics North-America, 58, 667–679.Google Scholar
  25. Steel, G.G., 1977, Growth kinetics of tumours, Clarendon Press. Oxford.Google Scholar
  26. Tubiana, M., Chauvel, P., Renaud, A., and Malaise, E.P., 1975, Vitesse de croissance et histoire naturelle du cancer du sein. Bull. Cancer (Paris), 62, 341–358.Google Scholar
  27. Tubiana, M., and Malaise, E.P., 1976, Comparison of cell proliferation kinetics in human and experimental tumors: response to irradiation. Cancer Treat. Rep., 60, 1887–1895.PubMedGoogle Scholar
  28. Tubiana, M., Pejovic, M.J., Renaud, A., Contesso, G., Chavaudra, N., Gioanni, J., and Malaise, E.P., 1980, Kinetic parameters and the course of the disease in breast cancer. Submitted to Cancer.Google Scholar
  29. Weiss, L., 1977, A pathobiologic overview of metastasis. Sem. Onc., 4, 5–17.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • M. Tubiana
    • 1
  • A. J. Valleron
    • 1
  • E. Malaise
    • 1
  1. 1.Institut Gustave RoussyVillejuifFrance

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