Advertisement

Morphological Aspects of Immunotherapy in Breast Cancer

  • J. M. Verley
  • K. H. Hollmann
  • R. Villet
  • J. Reynier

Abstract

There is evidence to believe that numerous immunostimulating agents of bacterial origin inhibit tumor growth in a variety of experimental systems and in some human tumors. The mechanism of this action seems to be mainly related to stimulation of the reticuloendothelial system (or mononuclear phagocyte system, Lennert, 1978) with activation of macrophages (Halpern et al., 1966), but its morphological basis has not been clearly elucidated.

Keywords

Mammary Tumor Drain Lymph Node Morphological Aspect Tumor Bearing Mycobacterium Bovis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baldwin, R.W., 1973, Immunological aspects of carcinogenesis. Adv. Cancer Res., 18, 1–75.PubMedCrossRefGoogle Scholar
  2. Baldwin, R.W., 1976, Relevant animal models for tumor immunotherapy. Cancer Immunol. Immunother., 1, 197–198.CrossRefGoogle Scholar
  3. Bartlett, G.L., Zbar, B., and Rapp, H.J., 1972, Suppression of murine tumor growth by immune reaction to the Bacillus Calmette Guerin strain of Mycobacterium bovis. J. Natl. Cancer Inst., 48, 245–257.PubMedGoogle Scholar
  4. Bizzini, B., Maro, B., and Lallouette, P., 1978, Isolement et caractérisation d’une fraction (P 40) isolée de Corynebacterium Granulosum. Médecine et Maladies infectieuses, 8, 408–414.CrossRefGoogle Scholar
  5. Black, M.M., Zachrau, R.E., Shore, B., Moore, D.H., and Leis, H.P., 1975, Prognostically favorable immunogens of human breast cancer tissue: Antigenic similarity to murine mammary tumor virus. Cancer, 35, 121–128.PubMedCrossRefGoogle Scholar
  6. Cutler, S.J., Black, M.M., Friedell, G.H., Vidone, R.A., and Goldenberg, I.S., 1966, Prognostic factors in cancer of the female breast. Cancer, 19, 75–82.PubMedCrossRefGoogle Scholar
  7. Fauve, R.M., 1975, Stimulating effect of Corynebacterium parvum and Corynebacterium extract on the macrophage activities against Salmonella typhimurum and Listeria monocytogenes. In: B. Halpern (ed.), Corynebacterium parvum. Application in experimental and clinical oncology. pp 77–83. New York: Plenum Press.Google Scholar
  8. Fisher, B., Gebhardt, M., Linta, J., and Saffer, E., 1978, Comparison of the inhibition of tumor growth following local or systemic administration of Corynebacterium parvum or other immunostimulating agents with or without cyclophosphamide. Cancer Res., 38, 2679–2687.PubMedGoogle Scholar
  9. Greager, J.A., and Baldwin, M.W., 1978, Influence of immunotherapic agents on the progression of spontaneous arising metastazing rat mammary adenocarcinomas of varying immunogenicities. Cancer Res., 38, 69–73.PubMedGoogle Scholar
  10. Halpern, B., Prevot, A.R., Biozzi, G., Stiffel, C., Mouton, D., Morard, J.C., Bouthillier, Y., and Decreusefond, C., 1963a, Stimulation de l’activité du systeme réticuloendothélial provoquée par Corynebacterium parvum. J. Réticuloendothél. Soc., 1, 77–96.Google Scholar
  11. Halpern, B.N., Haguenau, F., and Hollmann, K.H., 1963b. Modifications ultrastructurales observées dans le foie et dans la rate de souris après injection d’extraits bactériens. In: Rôle du Système réticulo-endothélial dans l’immunité antibactérienne et anti-tumorale. B.N. Halpern ed., Centre National de la Recherche Scientifique, Paris, pp 249–259.Google Scholar
  12. Halpern, B., Biozzi, G., Stiffel, C., and Mouton, D., 1966, Inhibition of tumor growth by administration of killed Corynebacterium parvum. Nature, 212, 853–854.PubMedCrossRefGoogle Scholar
  13. Hanna, M.G., Jr., Zbar, B., and Rapp, K.J., 1972, Histopathology of tumor regression after intralesional injection of Mycobacterium bovis. I. Tumor growth and metastasis. J. Natl. Cancer Inst., N° 48, 1441–1455.PubMedGoogle Scholar
  14. Hanna, M.G., Jr., Snodgrass, M.J., Zbar, B., and Rapp, H.J., 1973, Histopathology of tumor regression after intralesional injection of Mycobacterium bovis. IV. Development of immunity to tumor cells and BCG. J. Natl. Cancer Inst., 51, 1897–1908.PubMedGoogle Scholar
  15. Huggins, C., Grand, L.G., and Brillantes, F.P., 1961, Mammary cancer induced by a single feeding of polynuclear carbons and its suppression. Nature, 189, 204–207.PubMedCrossRefGoogle Scholar
  16. Hunter, R., Ferguson, D., and Coplleson, W., 1975, Survival with mammary cancer related to the interaction of germinal center hyperplasia and sinus histiocytosis in axillary and internal mammary lymph nodes. Cancer, 36, 526–539.CrossRefGoogle Scholar
  17. Khalil, A., Bourut, Ch., Halle-Pannenko, O., Mathe, G., and Rappaport, H., 1975, Histologic reactions of the thymus, spleen, liver and lymph nodes to intravenous and subcutaneous BCG injections. Biomedicine, 22, 112–121.PubMedGoogle Scholar
  18. Kozlowski, H., and Hrabowska, M., 1978, Stages of the development of immunologic response in regional lymph nodes draining breast cancer. Neoplasma, 25, 445–452.PubMedGoogle Scholar
  19. Lennert, K., 1978, Malignant lymphomas. Springer, Berlin, Heidelberg, New York.Google Scholar
  20. Lennert, K., 1979, Introductory remarks. In: Function and structure of the immune system. W. Müller-Ruchholtz and H.K. Müller-Hermelink eds., Plenum Press, New York. pp.1–9.Google Scholar
  21. Meyer, E.M., and Grundmann, E., 1980, BCG-induced changes in size of thymic cortex and thymus-dependent areas in spleen and lymph nodes of mice. Clin. Exp. Immunol., 39, 60–65.PubMedGoogle Scholar
  22. Moore, R.D., Lamm, M.E., Lockman, L.A., and Schoenberg, M.D., 1963, Cellular aspects of the action of Freund’s adjuvant in the spleen and lymph nodes. Brit. J. Exp. Path., 44, 300–311.Google Scholar
  23. Prehn, R.T., 1975, Relation-ship of tumor immunogenicity to concentration of the oncogen. J. Natl. Cancer Inst., 55, 189–190.PubMedGoogle Scholar
  24. Rosenberg, S.A., and Rapp, K.J., 1976, Intralesional immunotherapy of melanoma with BCG. Med. Clin. North Am., 60, 419–430.PubMedGoogle Scholar
  25. Scott, M.T., 1974, Corynebacterium parvum as a therapeutic antitumor agent in mice. II. Local injection. J. Natl. Cancer Inst., 53, 861–865.Google Scholar
  26. Silverberg, I., Chitale, A., Hind, A., Frozier, A., and Kevitt, S., 1970, Sinus histiocytosis and mammary carcinoma. Cancer, 26, 1177–1185.PubMedCrossRefGoogle Scholar
  27. Simar, L.J., 1973, Modifications structurales des ganglions drainant un greffon allogénique. Relation avec la reaction inflammatoire du greffon. Arch. Anat. Path., 21, 13–28.Google Scholar
  28. Verley, J.M., Hollmann, K.H., Villet, R., and Reynier, J., Immunostimulation of rats bearing DMBA induced mammary carcinoma. Histopathology and ultrastructure of the tumors and regional lymph nodes after local injection of P 40. In press.Google Scholar
  29. Zbar, B., Bernstein, I.D., Bartlett, G.L., Hanna, M.G., and Rapp, H.J., 1972, Immunotherapy of cancer: Regression of intradermal tumor and prevention of growth of lymph node metastases after intralesional injection of living mycobacterium bovis. J. Natl. Cancer Inst., 49, 119–130.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • J. M. Verley
    • 1
  • K. H. Hollmann
    • 1
  • R. Villet
    • 2
  • J. Reynier
    • 2
  1. 1.Hopital Marie-LannelongueLe Plessis RobinsonFrance
  2. 2.Service de ChirurgieHopital BoucicautParis Cedex 15France

Personalised recommendations