Immunotherapy of Spontaneously Arising Rat Mammary Tumours
Numerous studies with experimentally-induced animal tumours have demonstrated the potential of introducing immunotherapy as a component in the treatment of human malignant disease (Baldwin and Pimm, 1978; Baldwin and Byers, 1979; Milas and Scott, 1977) and many clinical trials are currently in progress (Goodnight and Morton, 1978). But many of the experimental tumours used in designing immunotherapy protocols, e. g. carcinogen-induced tumours have been criticized as not being appropriate models for human malignant disease since they frequently express neoantigens which elicit strong rejection responses, whereas the clinical evidence for host immunity to human cancer is not fully substantiated (Castro, 1978). The studies presented here were designed to investigate whether naturally arising (spontaneous) rat mammary carcinomas can be controlled by immunotherapy. Several approaches were evaluated for this purpose including active specific immunotherapy involving treatment with vaccines containing tumour cells together with an immunological adjuvant, since this approach is effective with carcinogen-induced tumours (Pimm and Baldwin, 1978; Baldwin and Byers, 1979). Regional immunotherapy, in which immunostimulating agents are administered so as to localize in tumour deposits, was also evaluated since there is a growing evidence to indicate that non-specific immunity mediated by macrophages and/or natural killer cells can be effective against animal and human tumours (Baldwin and Byers, 1979; Herberman and Holden, 1979).
KeywordsMammary Carcinoma Active Specific Immunotherapy Bacterial Vaccine Cancer Research Campaign Corynebacterium Parvum
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