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Relationship Between Cytosolic Free Calcium Ion Concentration and the Control of Pyruvate Dehydrogenase in Isolated Cardiac Myocytes and Synaptosomes

  • Richard G. Hansford
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 232)

Abstract

It is clear that the Ca2+ ion plays a central role in the mechanism of excitation-contraction coupling in muscle and in excitation-secretion coupling at the synapse (see, e.g. Katz, 1970; Rasmussen, 1981). What is perhaps not so well known is that in each case Ca2+ may also act as a signal to cause the activation of mitochondrial substrate oxidation. The increase in cytosolic free Ca2+ ([Ca2+]) on excitation of muscle cells activates actomyosin ATPase; the increase in [Ca2+] in a presynaptic nerve terminal upon depolarization triggers transmitter substance release, and occurs essentially at the same time as a decrease in the magnitude of Na+ and K+ -ion gradients, the latter requiring increased flux through the Na+ -K+ -ATPase for re-establishment. In each case, tissue activation is accompanied by increased utilization of ATP, with a consequently increased demand upon oxidative phosphorylation to re-synthesize ATP. It is the thesis of this article that Ca2+ acts as a signal to enhance mitochondrial substrate oxidation, so that energy supply and demand can be kept in balance.

Keywords

Cardiac Myocytes Pyruvate Dehydrogenase Brain Mitochondrion Presynaptic Nerve Terminal Proton Electrochemical Gradient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Richard G. Hansford
    • 1
  1. 1.National Institute on AgingGerontology Research CenterBaltimoreUSA

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