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AGEPC: A Potent Calcium-Dependent Chemical Mediator in the Liver

  • Rory A. Fisher
  • Denis B. Buxton
  • David S. Lapointe
  • Donald J. Hanahan
  • Merle S. Olson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 232)

Abstract

AGEPC (i.e. 1-0-alkyl-2-acetyl- sn -glycero-3-phosphocholine) or platelet activating factor is a unique phosphoglyceride first described as a fluid phase mediator of platelet aggregation during immunoglobulin E-induced anaphylaxis in the rabbit (1,2). AGEPC is produced in response to various stimuli in a variety of cells including neutrophils, basophils, monocytes and mast cells (3-7), and is among the most potent mediators formed and released by biological tissues. AGEPC induces aggregation and degranulation of platelets and neutrophils at subnanomolar concentrations (8,9) and is thought to act by interaction with specific receptors (10–13). In platelets, AGEPC-induced aggregation is associated with the turnover of inositol phospholipids, production of phosphatidic acid and protein phosphorylation (12–15). Additional studies have indicated that AGEPC possesses diverse biological actions including contraction of smooth muscles (16–18), negative inotropic cardiac effects (19,20), vasoconstriction (21,22), and exocrine gland stimulation (23). We have recently found that AGEPC possesses a powerful regulatory effect on hepatic metabolism which is the subject of this report.

Keywords

Phosphatidic Acid Glucose Output Portal Pressure Glycogen Phosphorylase Perfuse Liver 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Rory A. Fisher
    • 1
  • Denis B. Buxton
    • 1
  • David S. Lapointe
    • 1
  • Donald J. Hanahan
    • 1
  • Merle S. Olson
    • 1
  1. 1.Department of BiochemistryThe University of Texas Health Science CenterSan AntonioUSA

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