Abnormal Ca2+ Transport Characteristics of Hepatoma Mitochondria and Endoplasmic Reticulum
The oncogenic transformation of cells from a normal to malignant phenotype is associated with a variety of experimentally discernible changes in the pattern of metabolism. Many of these alterations involve processes modulated by the intracellular level and distribution of calcium. In addition to increased growth rates, Ca2+ may play a specific role in the increased rates of aerobic glycolysis (Cittadini et al., 1981), elevated rates of cholesterol synthesis (Beg et al., 1985), and alterations in cytoskeletal organization and function (Ben-Ze’ev, 1985). Given these and other observations of alterations of cellular processes associated with malignancy, the general hypothesis has surfaced that tumor cell calcium metabolism is abnormal.
KeywordsPyridine Nucleotide Ehrlich Ascites Tumor Cell Inositol Trisphosphate Adenine Nucleotide Transport Tumor Mitochondrion
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