Phosphonate Analogues of Diadenosine Tetraphosphate as Substrates and Inhibitors of Artemia Dinucleoside Tetraphosphatase
P1,P4 -bis(5′-nucleosidyl) tetraphosphate pyrophosphohydrolase (dinucleoside tetraphosphatase, Np4Nase, E.C.18.104.22.168) is believed to be responsible for the catabolism of the proposed signal nucleotide P1,P4 -bis(5′-adenosyl) tetraphosphate (diadenosine tetraphosphate, Ap4A) and related compounds in a wide variety of cell types. It is also a candidate for the enzyme involved in the degradation of the purine ring store Gp4G during pre-emergence and early larval development in Artemia (see accompanying paper for detailed discussion and references).
KeywordsAdenylate Kinase Ammonium Phosphate Binding Inter Tetrabutylammonium Salt Early Larval Development
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