Advertisement

Regulation of the Synthesis, Release and Action of Hypothalamic Luteinizing Hormone Releasing Hormone

  • George Fink
  • Ann Curtis
  • Val Lyons
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

Hans Lindner like Geoffrey Harris was an adherent of the law of parsimony. Although the application of this law (‘Occam’s razor’) to physiology has been challenged by a number of recent discoveries, the law appears to be upheld in the case of luteinizing hormone releasing hormone (LHRH) the decapeptide that mediates the neural control of gonadotropin secretion. This peptide not only stimulates the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) but also stimulates the synthesis of the gonadotropins, maintains the structure of the gonadotrophs and has the apparently unique property (for neuropeptides studied so far) of sensitizing the pituitary gland to itself (the priming effect of LHRH). Furthermore, as discussed in other chapters of this book, LHRH may exert a direct effect on the gonads, and may serve as a neurotransmitter in parts of the nervous system remote from the hypothalamus.

Keywords

Luteinizing Hormone Follicle Stimulate Hormone Translation Product Luteinizing Hormone Release Hormone Estradiol Benzoate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A.V. Schally, A. Arimura and A.J. Kastin, Science 179: 341 (1973).PubMedCrossRefGoogle Scholar
  2. 2.
    W. Vale, C. Rivier and M. Brown, Ann. Rev. Physiol. 39: 473 (1977).CrossRefGoogle Scholar
  3. 3.
    G. Fink, in: Recent Advances in Obstetrics and Gynaeco ogy, J. Stallworthy and G. Bourne, eds., pp. 4–54, Churchill Livingstone, Edinburgh (1977).Google Scholar
  4. 4.
    G. Fink, Brit. Med. Bull. 35: 155 (1979).PubMedGoogle Scholar
  5. 5.
    G. Fink and A. Pickering, in: Synthesis and Release of Adenohypophyseal Hormones, M. Jffisz and K. McKerns, eds., pp. 617–638, Plenum Press, New York (1980).Google Scholar
  6. 6.
    G. Fink, M. Aiyer, S. Chiappa, S. Henderson, M. Jamieson, V. Levy-Perez, A. Pickering, D. Sarkar, N. Sherwood, A. Speight and A. Watts, in: Hormonally Active Brain Peptides, K. McKerns and V. Pantic, eds., pp. 397–426, Plenum Press, New York (1982).Google Scholar
  7. 7.
    G. Fink, H.F. Stanley and A.G. Watts, in: Brain Peptides, D. Krieger, M. Brownstein and J. Martin’, eds., pp. 413–435, John Wiley & Sons Inc., New York (1983).Google Scholar
  8. 8.
    B.M. Cattanach, C.A. Iddon, H.M. Charlton, S.A. Chiappa and G. Fink, Nature 269: 338 (1977).PubMedCrossRefGoogle Scholar
  9. 9.
    R.P. Millar, C. A iinelt, G. Rossier, Biochem. Biophys. Res. Commun. 74: 720 (1977).PubMedCrossRefGoogle Scholar
  10. 10.
    J.P. Gautron, E. Pattou and C. Kordon, Mol. Cell Endocrinol. 24: 1 (1981).PubMedCrossRefGoogle Scholar
  11. 11.
    A. Curtis and G. Fink, Endocrinology 112: 390 (1983).PubMedCrossRefGoogle Scholar
  12. 12.
    A. Curtis, V. Lyons and G. Fink, Biochem. Biophys. Res. Commun. 117: 872 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    U. Laemmli, Nature 222: 680 (1970).CrossRefGoogle Scholar
  14. 14.
    M.R. Morrisonn and W T. Griffin, Anal. Biochem. 113: 318 (1981).CrossRefGoogle Scholar
  15. 15.
    R.C. Tsou, R.A. Dailey, C.S. McLanahan, A.D. Parent, G.T. Tindall and J.D. Neill, Endocrinology 101: 534 (1977).PubMedCrossRefGoogle Scholar
  16. 16.
    I.J. Clarke and J.T. Cummins, Endocrinology 111: 1737 (1982).CrossRefGoogle Scholar
  17. 17.
    P.W. Carmel, S. Araki and M. Ferin, Endocrinology 99: 243 (1976).PubMedCrossRefGoogle Scholar
  18. 18.
    J.D. Neill, R.A. Dailey, R.C. Tsou, J. Patton and G. Tindall, in: Ovulation in the Human, P.G. Crosignani and D.R. Mishell, eds., pp. 115–125, Academic Press, New York (1976).Google Scholar
  19. 19.
    J.D. Neill, J.M. Patton, R.A. Dailey, R.C. Tsou and G.T. Tindall, Endocrinology 101: 430 (1977).PubMedCrossRefGoogle Scholar
  20. 20.
    G. Fink and M.G. Jamieson, J. Endocrinol. 68: 71 (1976).PubMedCrossRefGoogle Scholar
  21. 21.
    R.L. Eskay, R.S. Mical and J.C. Porter, Endocrinology 100: 263 (1977).PubMedCrossRefGoogle Scholar
  22. 22.
    M.G. Jamieson and G. Fink, J. Endocrinol. 68: 57 (1976).PubMedCrossRefGoogle Scholar
  23. 23.
    S.A. Chiappa, G. Fink and N.M. Sherwood, J. Physiol. 267: 625 (1977).PubMedGoogle Scholar
  24. 24.
    N.M. Sherwood, S.A. Chiappa and G. Fink, Endocrinology 70: 501 (1976).CrossRefGoogle Scholar
  25. 25.
    D.K. Sarkar, S.A. Chiappa, G. Fink and N.M. Sherwood, Nature 264: 461 (1976).PubMedCrossRefGoogle Scholar
  26. 26.
    N.M. Sherwood and G. Fink, Endocrinology 106: 363 (1980).PubMedCrossRefGoogle Scholar
  27. 27.
    N.M. Sherwood, S.A. Chiappa, D.K. Sarkar Wrid G. Fink, Endocrinology 107: 1410 (1980).PubMedCrossRefGoogle Scholar
  28. 28.
    M. Ching, Neuroendocrinology 34: 279 (1982).PubMedCrossRefGoogle Scholar
  29. 29.
    D.K. Sarkar and G. Fink, J. Endocrinol. 83: 339 (1979).PubMedCrossRefGoogle Scholar
  30. 30.
    D.K. Sarkar and G. Fink, J. Endocrinol. 80: 303 (1979).PubMedCrossRefGoogle Scholar
  31. 31.
    D.K. Sarkar and G. Fink, J. Endocrinol. 86: 511 (1980).PubMedCrossRefGoogle Scholar
  32. 32.
    R.E. Leipheimen and R.V. Gallo, Neuroendocrinology 37: 421 (1983).CrossRefGoogle Scholar
  33. 33.
    C.H. Sawyer, Neuroendocrinology 17: 97 (1975).PubMedCrossRefGoogle Scholar
  34. 34.
    G. Fink and L.B. Geffen, in: International Review of Physiology, vol. 17, Neurophysiology III, R. Porter, ed., pp. 1–48, University Park Press, Baltimore (1978).Google Scholar
  35. 35.
    R.I. Weiner and W.F. Ganong, Physiol. Rev. 58: 905 (1978).PubMedGoogle Scholar
  36. 36.
    D.K. Sarkar and G. Fink, Endocrinology 108: 862 (1981).PubMedCrossRefGoogle Scholar
  37. 37.
    C.A. Barraclough and P.M. Wise, Endocrinol. Rev. 1: 91 (1982).CrossRefGoogle Scholar
  38. 38.
    D.K. Sarkar, G.C. Smith and G. Fink, Brain Res. 213: 335 (1981).PubMedCrossRefGoogle Scholar
  39. 39.
    T.J. Cicero, T.M. Badger, C.E. Wilcox, R.D. Bell and E.R. Meyer, J. Pharmacol. 203: 548 (1977).Google Scholar
  40. 40.
    T.J. Cicero, B.A. Schainker and E.R. Meyer, Endocrinology 104: 1286 (1979).PubMedCrossRefGoogle Scholar
  41. 41.
    D.A. Van Vugt, P.W. Sylvester, C.F. Aylsworth and J. Meites, Neuroendocrinology 34: 274 (1982).PubMedCrossRefGoogle Scholar
  42. 42.
    R. Bhanot and M. Wilkinson, Endocrinology 113: 596 (1983).PubMedCrossRefGoogle Scholar
  43. 43.
    R. Bhanot and M. Wilkinson, Endocrinology 112: 399 (1983).PubMedCrossRefGoogle Scholar
  44. 44.
    R.P. Millar, W.J. Sheward, I. Wegener and G. Fink, Brain Res. 260: 334 (1983).PubMedCrossRefGoogle Scholar
  45. 45.
    W. J. Sheward, A.J. Harmar, H.M. Fraser and G. Fink, Endocrinology 113: 1865 (1983).PubMedCrossRefGoogle Scholar
  46. 46.
    G. W. Frink, Ann. Rev. Physiol. 41: 571 (1979).CrossRefGoogle Scholar
  47. 47.
    G.W. Harris and D. Jacobsohn; Proc. R. Soc. B. 139: 263 (1952).CrossRefGoogle Scholar
  48. 48.
    M. Nikitovitch-Winer and J.W. Everett, Endocrinology 63: 916 (1958).PubMedCrossRefGoogle Scholar
  49. 49.
    M. Nikitovitch-Winer and J.W. Everett, Endocrinology 65: 357 (1959).PubMedCrossRefGoogle Scholar
  50. 50.
    P.E. Smith, Endocrinology 68: 130 (1961).CrossRefGoogle Scholar
  51. 51.
    G. Fink and G.C. Smith, Z. Zellforsch. 119: 208 (1971).PubMedCrossRefGoogle Scholar
  52. 52.
    S.A. Chiappa and G. Fink, J. Endocrinol. 71: 211 (1977).CrossRefGoogle Scholar
  53. 53.
    T.-C. Liu and G.L. Jackson, Endocrinology 103: 1253 (1978).PubMedCrossRefGoogle Scholar
  54. 54.
    T.-C. Liu and G.L. Jackson, Endocrinology 104: 962 (1979).PubMedCrossRefGoogle Scholar
  55. 55.
    S. Azhar, J.R. Reel, C.A. Pastushok and K.M.J. Menon, Biochem. Biophys. Res. Commun. 80: 659 (1978).PubMedCrossRefGoogle Scholar
  56. 56.
    C.A. Iddon, H.M. Charlton and G. Fink, J. Endocrinol. 85: 105 (1980).PubMedCrossRefGoogle Scholar
  57. 57.
    I.F.W. McDowell, J.F. Morris, H.M. Charlton and G. Fink, J. Endocrinol. 95: 331 (1982).PubMedCrossRefGoogle Scholar
  58. 58.
    H.M. Charlton, D.M.G. Halpin, C. Iddon, R. Rosie, G. Levy, I.F.W. McDowell, A. Megson, J.F. Morris, A. Bramwell, A. Speight, B.J. Ward, J. Broadhead, G. Davey-Smith and G. Fink, Endocrinology 113: 535 (1983).PubMedCrossRefGoogle Scholar
  59. 59.
    H.M. Charlton, A. Speight, D.M.G. Halpin, A. Bramwell, W.J. Sheward and G. Fink, Endocrinology 113: 545 (1983).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • George Fink
    • 1
  • Ann Curtis
    • 1
  • Val Lyons
    • 1
  1. 1.Department of PharmacologyMRC Brain Metabolism UnitEdinburghScotland

Personalised recommendations