Hypothalamic-Pituitary-Gonadal Axis: Concluding Remarks

  • George Fink
Part of the Biochemical Endocrinology book series (BIOEND)


During the last five days we have been treated to a feast of sophisticated data on the interactions that occur between the brain, the anterior pituitary gland and the gonads. In the female of most mammals these interactions result in a spontaneous surge of LH which causes ovulation and the formation of corpora lutea (Figs. 1 and 2). Essentially, the hypothalamic-pituitary system and the ovary can be considered as two oscillators which achieve resonance at regular intervals (with a frequency of 4 days to a year) to result in the LH surge and ovulation. In the male the interactions between the hypothalamic-pituitary system and the gonads are less dramatic than in the female, but lead to the equally important production of sperm and androgens. The nature of the interactions within and between components of the hypothalamic-pituitary-gonadal axis was the subject of this meeting, and Hans Lindner would have been delighted with the level of most of the presentations and discussion.


Pituitary Gland Corpus Luteum Anterior Pituitary Gland Ovarian Follicle Animal Spirit 
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    G. Fink, in: Recent Advances in Obstetrics and Gynaecology, J. Stallworthy and G. Bourne, eds., pp. 4–54, Churchill Livingstone, Edinburgh (1977).Google Scholar
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    G. Fink, Brit. Med. Bull. 35: 155 (1979).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • George Fink
    • 1
  1. 1.Department of PharmacologyMRC Brain Metabolism UnitEdinburghScotland

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