On the Mode of Action of an LHRH Agonist in Man and Its Potential Use as Contraceptive

  • David Rabin
  • Robert M. Evans
  • Gregory C. Doelle
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

The isolation of LHRH (Schally et al., 1971; Burgus et al., 1971) was followed by the development of a large number of analogs (Vale et al., 1977). The compound D-Trp6-Pro9-N-Ethylamide LHRH (LHRHA) has a potency 144 times that of native LHRH in causing LH release in in vitro systems (Vale et al., 1977). However, when administered in vivo to the rat, “paradoxical” gonadal atrophy was observed (Tcholakian et al., 1978; Sandow et al., 1980).

Keywords

Testosterone Polypeptide Androgen Kelly Vale 

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References

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • David Rabin
    • 1
  • Robert M. Evans
    • 1
  • Gregory C. Doelle
    • 1
  1. 1.Division of EndocrinologyVanderbilt University School of MedicineNashvilleUSA

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