On the Mode of Action of an LHRH Agonist in Man and Its Potential Use as Contraceptive

  • David Rabin
  • Robert M. Evans
  • Gregory C. Doelle
Part of the Biochemical Endocrinology book series (BIOEND)


The isolation of LHRH (Schally et al., 1971; Burgus et al., 1971) was followed by the development of a large number of analogs (Vale et al., 1977). The compound D-Trp6-Pro9-N-Ethylamide LHRH (LHRHA) has a potency 144 times that of native LHRH in causing LH release in in vitro systems (Vale et al., 1977). However, when administered in vivo to the rat, “paradoxical” gonadal atrophy was observed (Tcholakian et al., 1978; Sandow et al., 1980).


Luteinizing Hormone Luteinizing Hormone Receptor LHRH Agonist Serum Luteinizing Hormone Sperm Density 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • David Rabin
    • 1
  • Robert M. Evans
    • 1
  • Gregory C. Doelle
    • 1
  1. 1.Division of EndocrinologyVanderbilt University School of MedicineNashvilleUSA

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