Application of GnRH for Induction of Ovulation in Anovulatory Menstruating Women

  • Vaclav Insler
  • Gershon Hochberg
  • Joseph Levy
  • Gad Potashnik
  • David Goldstein
Part of the Biochemical Endocrinology book series (BIOEND)


The presence of LH-releasing activity in hypothalamic extracts was reported by McCann and co-workers in 1960. Shortly afterwards Campbell et al.(1964) showed that similar extracts, when injected into the pituitary gland were capable of inducing ovulation. In less than 10 years Luteinizing Hormone Releasing Hormon (LHRH or GnRH) was purified, its amino-acid sequence was identified and confirmed by synthesis (Matsuo et al., 1971).This opened new exciting avenues for important physiological studies and for the development of antisera which could be used as a basis for devising radioimmunoassays of GnRH and for precise localization of the peptide by immunocytochemistry. Synthesis of large quantities of GnRH enabled large-scale clinical studies which, in turn, produced important information on the role of this hormone in the reproductive process. Synthesis of new GnRH analogs, both agonistic and antagonistic (Schally et al.,1981) further expanded the application of this hormone for clinical and research purposes.


Precocious Puberty Ovulation Induce Luteinizing Hormone Release Follicular Maturation GnRH Stimulation 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Vaclav Insler
    • 1
  • Gershon Hochberg
    • 1
  • Joseph Levy
    • 1
  • Gad Potashnik
    • 1
  • David Goldstein
    • 1
  1. 1.Division of Obstetrics and Gynecology Soroka Medical CenterBen-Gurion University of the NegevBeer-ShebaIsrael

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