Molecular Heterogeneity of Luteinizing Hormone-Releasing Hormone

  • Robert P. Millar
  • Judy A. King
Part of the Biochemical Endocrinology book series (BIOEND)


Following the structural elucidation of luteinizing hormone-releasing hormone (LH-RH) by Schally and associates, it became generally accepted that the decapeptide was a unique molecular form. This belief arose from:
  1. (a)

    A number of studies purporting to have shown non-ribosomal biosynthesis of LH-RH and thereby excluding the possibility of ribosomally biosynthesised prohormonal forms.

  2. (b)

    The assumption that LH-RH was confined to the CNS and thus unlikely to be present in other tissues in a modified form.

  3. (c)

    Immunological and low resolution chromatographic studies demonstrating that LH-RH in the hypothalamus of nonmammalian vertebrates was identical to the mammalian peptide. This conclusion of a lack of interspecific differences in LH-RH structure in vertebrates was supported by the demonstration that synthetic mammalian LH-RH was biologically active in a wide range of mammalian species and in nonmammalian vertebrates (1).



Luteinizing Hormone Molecular Heterogeneity Substantial Biological Activity High Molecular Weight Form Nonmammalian Vertebrate 


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Robert P. Millar
    • 1
  • Judy A. King
    • 1
  1. 1.Department of Chemical PathologyUniversity of Cape Town Medical SchoolObservatorySouth Africa

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