Follicle Stimulating Hormone Regulation of Phosphodiesterase and Cell Response

  • M. Conti
  • R. Geremia
  • M. V. Toscano
  • M. Stefanini
Part of the Biochemical Endocrinology book series (BIOEND)


In the last decade a large body of work has focused on the mechanisms of action of protein hormones. Properties of receptors, receptor-hormone interaction, activation of adenylate cyclase, and initiation of the cAMP-dependent cascade have been described in many systems in great detail. Conversely, little attention has been devoted to the termination of the hormonal stimulus, and little is known about the mechanisms that govern this process. There is now abundant evidence that hormone binding to the receptor is not always completely reversible (l–3), and in some instances a stable hormone-receptor complex is internalized in the cell (4–8). Therefore dissociation of the hormone from its receptor can no longer be considered the primary cause of the cessation of the hormonal stimulation. In addition to stimulating the function of their targets, it has also become clear that hormones induce profound changes in the response of the cells (9) so that repeated exposure to the same hormone leads to an attenuated response (refractoriness). The boundary between the mechanisms of regulation of cell response and cessation of the primary stimulation is not clearly defined, and it is possible that both are aspects of a common phenomenon.


Granulosa Cell Adenylate Cyclase Follicle Stimulate Hormone Sertoli Cell Seminiferous Tubule 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • M. Conti
    • 1
  • R. Geremia
    • 1
  • M. V. Toscano
    • 1
  • M. Stefanini
    • 1
  1. 1.Institute of Histology and General EmbryologyUniversity of RomeRomeItaly

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