Hormones in Antral Fluid and the Regulation of Ovarian Function

  • Griff T. Ross
Part of the Biochemical Endocrinology book series (BIOEND)


At a symposium on ovulation held under the auspices of the Society for the Study of Fertility in July 1976, Hans Lindner presented a paper entitled, “Intraovarian Factors in Ovulation: Determinants of Follicular Response to Gonadotropins.” In addition to a critical scholarly review, the paper contained a summary of contributions made by his associates in the Department of Hormone Research at the Weizmann Institute of Science. The paper reflected not only the breadth of Hans’, scholarship but the diversity of skills of the group of younger scientists whom he had attracted and motivated to work so productively on various aspects of hormonal regulation of ovulation and atresia in mammalian ovarian follicles.


Granulosa Cell Embryo Transfer Luteal Phase Follicular Fluid Antral Follicle 
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  1. Aedo, A. R., Pedersen, P. H., Pedersen, S. C. and Diczfalusy, E., 1980, Ovarian steroid secretion in normally menstruating women, I. Contribution of the developing follicle, Acta Endocrinol. (KBH), 95: 212.Google Scholar
  2. Baird, D. T. and Fraser, I. S., 1975, Concentrations of estrone and estradiol in follicular fluid and ovarian venous blood in women, Clin. Endocrinol.,4:259.Google Scholar
  3. Bomsel-Helmreich, O., Gougeon, A., Thebault, A., Saltarelli, D., Milgrom, E., Frydman, R., and Papiernik, E., 1979, Healthy and atretic human follicles in the preovulatory phase: Differences in evolution of follicular morphology and steroid content of follicular fluid, J. Clin. Endocrinol. Metab.,48:68Google Scholar
  4. Brailly, S., Gougeon, A., Milgrom, E., Bomsel-Helmreich, 0., and Papiernik, E., 1981, Androgens and progestins in the human ovarian follicle: Differences in evolution of preovulatory, healthy nonovulatory and atretic follicles, J. Clin. Endocrinol. Metab.,53: 128.Google Scholar
  5. Brailly, S., Gougeon, A., Milgrom, E., Bomsel-Helmreich, 0., and Papiernik, E., Importance of changes in the transformation of progestin into androgen during preovulatory development and atresia of human follicles, in: “Follicular Maturation and Ovulation,” R. Rolland, E. V. Van Hall, S. G. Hillier, K. P. McNatty and J. Schoemaker, eds., Excerpta Medica, Amsterdam, Oxford-Princeton (1982).Google Scholar
  6. Byskov, A. G., Follicular atresia, in: “The Vertebrate Ovary,” R. E. Jones, ed., Plenum Press, New York and London (1978).Google Scholar
  7. Carson, R. S., Trounson, A. O., and Findlay, J. K., 1982, Successful fertilization of human oocytes in vitro Concentration of estradio1–17 beta, progesterone and androstenedione in the antral fluid of donor follicles, J. Clin. Endocrinol. Metab.,55:798.Google Scholar
  8. Di Zerega, G. S. and Hodgen, G. D., 1981, Folliculogenesis in the primate ovarian cycle, Endo. Rev.,2:26.Google Scholar
  9. Fleming, R. and Coutts, J. R. T., Oestrogen levels during follicular maturation in women, in: “Functional Morphology of the Human Ovary,” J. R. T. Coutts, ed., University Park Press, Baltimore (1981).Google Scholar
  10. Goodman, A. L., Nixon, W. E., Johnson, D. K., and Hodgen, G. D., 1977, Regulation of folliculogenesis in the cycling rhesus monkey: Selection of the dominant follicle, Endocrinology 100: 155.Google Scholar
  11. Hillier, S. G., Van den Boogaard, A. M. J., Reichers, L. E., Jr., Van Hall, G. V., 1981, Control of preovulatory follicular estrogen biosynthesis in the human ovary, J. Clin. Endocrinol. Metab 52:847.Google Scholar
  12. Hirshfield, A. N., Midgley, A. R., Jr., 1978, Morphometric analysis of follicular development in the rat, Biol. Reprod 19:597.Google Scholar
  13. Jones, H. W., Seegar-Jones, G., Andrews, M. C., Acosta, A., Bundren, C., Garcia, J., Sandow, B., Veeck, L., Wilkes, C., Witmyer, J., Wortham, J. E., Wright, G., 1982, The program for in vitro fertilization at Norfolk, Fertil. Steril.,38:14.Google Scholar
  14. Koering, M. J., 1969, Cyclic changes in ovarian morphology during the menstrual cycle in Macaca mulatta, Am. J. Anat.,126:73.Google Scholar
  15. Lindner, H. R., Amsterdam, A., Salomon, Y., Tsafriri, A., Nimrod, A., Lamprecht, S. A., Zor, U., and Koch, Y., 1977, Intraovarian factors in ovulation: Determinants of follicular response to gonadotropins, J. Reprod. Fertil.,51:215.Google Scholar
  16. Lopata, A., 1983, Concepts in human in vitro fertilization and embryo transfer, Fertil. Steril.,40:289.Google Scholar
  17. McNatty, K. P., Ovarian follicular development from the onset of luteal regression in humans and sheep, in: “Follicular Maturation and Ovulation,” R. Rolland, E. V. Van Hall, S. G. Hillier, K. P. McNatty, and J. Schoemaker, eds., Excerpta Medica, Amsterdam, Oxford-Princeton (1982).Google Scholar
  18. McNatty, K. P. and Baird, D. T., 1978, Relationship between follicle-stimulating hormone, androstenedione and estradiol in human follicular fluid, J. Endocrinol.,76:527.Google Scholar
  19. McNatty, K. P., Hillier, S. G., Van den Boogaard, A. M. J., TrimbosKemper, T. C. M., Reichert, L. E., Jr., and Van Hall, E. V., 1983, Follicular development during the luteal phase of the human menstrual cycle, J. Clin. Endocrinol. Metab.,52:1022.Google Scholar
  20. McNatty, K. P., Hunter, W. M., McNeilly, A. S., and Sawers, R. S., 1975, Changes in the concentration of pituitary and steroid hormones in the follicular fluid of human Graafian follicles throughout the menstrual cycle, J. Endocrinol.,64:555.Google Scholar
  21. McNatty, K. P., Makris, A., De Grazia, C., Osathanondh, R., and Ryan, K. J., 1979a, The production of progesterone, androgens, andestrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. J. Clin. Endocrinol. Metab.,49:687.Google Scholar
  22. McNatty, K. P., Smith, D. M., Makris, A., Osathanondh, R. and Ryan, K. J., 1979b, The microenvironment of the human antral follicle: Interrelationships among the steroid levels in antral fluid, the population of granulosa cells and the status of the oocyte in vivo and in vitro, J. Clin. Endocrinol. Metab.,49:851.Google Scholar
  23. Moor, R. M., Hay, M. F., Dott, H. M. and Cran, D. G., 1978, Macroscopic identification and steroidogenic function of atretic follicles in sheep, J. Endocrinol.,77:309.Google Scholar
  24. Nilsson, L., Wikland, M., and Hamberger, L., 1982, Recruitment of an ovulatory follicle in the human following follicle-ectomy and luteectomy, Fertil. Steril.,37:30.Google Scholar
  25. Peters, H. and McNatty, K. P. P., “The Ovary,” University of California Press, Berkeley and Los Angeles (1980).Google Scholar
  26. Quigley, M. M., Maklad, N. F., and Wolf, D. P., 1983, Comparison of two clomiphene citrate dosage regimens for follicular recruitment in an in vitro fertilization program, Fertil. Steril.,40:178.Google Scholar
  27. Spiers, A. L., Lopata, A., Gronow, M. J., Kellow, G. N., Johnston, W. I. H., 1983, Analysis of the benefits and risks of multiple embryo transfer, Fertil. Steril.,39:468.Google Scholar
  28. Steptoe, P. C., Edwards, R. G., and Purdy, J. M., 1980, Clinical aspects of pregnancies established with cleaving embryos grown in vitro, Br. J. Obstet. Gynecol. 87:757.Google Scholar
  29. Van Hall, E. V., Trimbos-Kemper, T. P. M., The surgical management of tubal infertility, in: “Gynecology and Obstetrics, Proceedings of the IXth World Congress of Obstetrics and Gynecology,” S. Sakamoto, S. Tojo, T. Nakayama, eds., Excerpta Medica, Amsterdam (1980).Google Scholar
  30. Webb, R. and England, B. G., 1982, Identification of the ovulatory follicle in the ewe: Associated changes in follicular size, thecal and granulosa cell luteinizing hormone receptors, antral fluid steroids, and circulating hormones during the preovulatory period, Endocrinol.,110: 873.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Griff T. Ross
    • 1
  1. 1.Sections of Endocrinology, Division of Reproductive Sciences, Dept. of Obstetrics, Gynecology, and Reproductive SciencesUniversity of Texas Medical School at HoustonHoustonUSA

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