Secretion and Action of Steroids in the Luteal Cell
The corpus luteum (CL) is a transient endocrine gland that synthesizes the steroid(s) necessary for ovum implantation and development of both placenta and fetus. In some species, such as primate and rat, the CL secretes both progesterone (P) and estradiol (E). However, luteal production of steroids is required for fetal survival throughout pregnancy in rats, while the CL is necessary only during early pregnancy in primates.
KeywordsCorpus Luteum Lipoprotein Receptor Theca Cell Luteal Cell Ovarian Vein
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- Azhar, S., and Menon, K.M.J., 1981, Receptor-mediated gonadotropin action in the ovary. Rat luteal cells preferentially utilize and are acutely dependent upon the plasma lipoprotein-supplied sterols in gonadotropins-stimulated steroid production, J. Biol. Chem., 256: 6518.Google Scholar
- Behrman, H.R., Luborsky-Moore, J.L., Pang, C.Y., Wright, K., and Dorflinger, L.J., 1979, Mechanisms of PGF2a action in functional luteolysis, in: “Ovarian Follicular and Corpus Luteum Function”, C. P. Channing, J. Marsh, and W. A. Sadler, eds., Plenum Press, New York.Google Scholar
- Blank, M.S., Dufau, M.L., and Friesen, H.G., 1979, Demonstration of potent gonadotropin-like biological activity in the serum of rats during mid-pregnancy, Life Sci., 92: 1527.Google Scholar
- Gibori, G., 1979, Steroidal regulation of luteal tissue function in pregnant rat, Endocrinology, 104: A585.Google Scholar
- Kalison, B., and Gibori, G., 1983, Role of prolactin in hCG stimulation of luteal cell production of testosterone and estradiol in the rat. in: “Factors Regulating Ovarian Function” G.S. Greenwald, and P.F. Terranova, eds., Raven Press, New York.Google Scholar
- Khan, M.I., Glaser, L., and Gibori, G., 1983, Reactivation of regressing corpora lutea by estradiol: Dependence on rat placental lactogen, Fed. Proc., 42: A143.Google Scholar
- Kovanen, P.T., Brown, M.S., and Goldstein, J.L., 1979, Increased binding of low density lipoprotein to liver membranes from rats treated with 17a-ethinyl estradiol, J. Biol. Chem., 245: 11367.Google Scholar
- Madhwa Raj, H.G., and Moudgal, N.R., 1970, Hormonal control of gestation in the intact rat, Endocrinology, 84: 874.Google Scholar
- Schuler, L.A., Scavo, L., Kirsch, T.M., Flickinger, G. L., and Strauss, J. F., III, 1979, Regulation of de novo biosynthesis of cholesterol and progestogens and formation of cholesteryl ester in rat corpus luteum by exogenous sterol, J. Biol. Chem., 245: 8662.Google Scholar
- Windier, T., Kovanen, P.T., Chao, Y.S., Brown, M.S., Havel, R.J., and Goldstein, J.L., 1980, The estradiol-stimulated lipoprotein receptor of rat liver, J. Biol. Chem., 255: 10464.Google Scholar
- Zmigrod, A., and Lindner, H. R., 1972, Oestrogen biosynthesis by the rat ovary in early pregnancy, Acta. Endocrinol. (Copenh), 69: 127.Google Scholar