Molecular Aspects of the Release of Luteinizing Hormone Releasing Hormone (LHRH) from Hypothalamic Neurons
LHRH, which is stored in granule-like particles within hypothalamic neurons (Goldsmith and Ganong, 1975; Barnea et al., 1978a,b), is released into the hypophysial portal blood under various physiological conditions. Since LHRH is a peptide, and since it has been established that peptides and polypeptides are released from secretory cells by exocytosis, it is conceivable that release of LHRH also occurs by exocytosis. In spite of the large body of information collected, thus far, regarding the identity of some substances which may regulate the secretion of LHRH from the hypothalamic neurons, little is known of the intracellular processes which underlie this release mechanism.
KeywordsLuteinizing Hormone Release Process Molecular Aspect LUTEINIZING Hormone Release Hormone Hypothalamic Neuron
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