Intraovarian Regulation of Follicular Granulosa Cell Differentiation
The cytodifferentiation process of follicular granulosa cells from immature rat ovaries is mainly regulated by FSH. Previous studies have shown that in response to in vivo or in vitro treatment with FSH, the granulosa cells produce progestins1,2, develop new receptors for LH3 and acquire aromatase enzyme complex which converts androgen substrate to estrogen4,5. Since FSH binding to the cell receptors results in stimulation of adenylate cyclase and accumulation of cAMP6,7, recent studies have tried to demonstrate that all the FSH induced effects mentioned above are cAMP mediated phenomena8–11.
KeywordsGranulosa Cell cAMP Formation Culture Granulosa Cell Ovarian Substance Follicular GRANULOSA Cell
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