Recent Progress in Cell Biology of Secretory Process in Anterior Pituitary Cells
The present concept on the secretory process in anterior pituitary cells is based on a large body of informations among which the contribution of electron microscopy was primordial. This concept follows the model formerly proposed by Palade for the exocrine pancreas and thereafter applied to several endocrine cells which secrete various polypeptides or proteins (see rev. Palade, 1975, Farquhar, 1981, Farquhar and Palade, 1981). There is now a complete agreement that the secretory process is a dynamic phenomenon which involves two main components: 1. the secretory protein itself which undergoes an intracellular transit before to be exported and 2. the intracellular membranes which limit the intracellular compartments where the secretory material is sequestered during its intracellular transit. These two aspects of the secretory process will be briefly reviewed.
KeywordsSecretory Granule Anterior Pituitary Cell Secretory Process Golgi Cisterna Golgi Zone
Unable to display preview. Download preview PDF.
- Farquhar, M.G., 1981, Membrane recycling in secretory cells: implications for traffic of products and specialized membranes within the Golgi complex. In: “Basic Mechanisms of Cellular Secretion. Methods in Cell Biology”, A. Hand and C. Oliver, eds, Academic Press, N.Y., vol. 23, pp. 339–427.Google Scholar
- Morin, A., and Tixier-Vidal, A., 1983, Effect of thyroliberin on prolactin turnover in two systems of rat prolactin cells: clonal GH3B6 cells and normal anterior pituitary cells in primary cultures. In: “Multihormonal Regulations in Neuro-endocrine cells”, A. Tixier-Vidal, and Ph. Richard, eds, INSERM, p. 593.Google Scholar
- Tartakoff, A.M., 1980, The Golgi complex: crossroads for vesicular traffic. Internat. Rev. Exper. Pathol., 22: 227–250.Google Scholar
- Tixier-Vidal, A., Tougard, C., and Morin, A., 1984, Cellular events involved in transport, storage and release of pituitary hormones. In: “Pituitary Hyperfunction: Physiopathology and Clinical Aspects”, G.M. Molinatti, F. Carmanini, and E.E. Muller, eds, Raven Press, N.Y., pp. 71–83.Google Scholar
- Tougard, C., Tixier-Vidal, A., Kerdelhué, B., and Jutisz, M., 1977, Etude immunocytochimique de l’évolution des cellules gonadotropes dans des cultures primaires de cellules antéhypophysaires de rat. Aspects quantitatifs et ultrastructuraux, Biol. Cell., 28: 251–260.Google Scholar
- Tougard, C., Picart, R., and Tixier-Vidal, A., 1982, Immunocytochemical localization of prolactin in the endoplasmic reticulum of GH3 cells. Variations in response to thyroliberin. Biol. Cell, 43: 89–102.Google Scholar