GnRH Receptor Microaggregation: Regulation of Gonadotropin Release, GnRH Receptors, and Gonadotrope Responsiveness

  • P. Michael Conn
  • Deloris C. Rogers
  • Sallie G. Seay
  • Lothar Jennes
  • Hyder Jinnah
  • Michael Bates
  • David Clapper
  • Diana Luscher
Part of the Biochemical Endocrinology book series (BIOEND)


Gonadotropin releasing hormone (GnRH) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) release from pituitary gonadotropes. Additional receptor-mediated actions of the releasing hormone include regulation of both the GnRH receptor and of cell responsiveness. While it is apparent that the release mechanism is Ca2+ mediated, it remains unclear how this receptor-mediated action is integrated with regulation of the receptor and of cell responsiveness. It is the purpose of this presentation to describe the requirements of gonadotropin release as well as receptor and response regulation in order to prepare an integrated model for these actions of the releasing hormone.


Luteinizing Hormone Pituitary Cell Receptor Occupancy GnRH Antagonist GnRH Analog 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • P. Michael Conn
    • 1
  • Deloris C. Rogers
    • 1
  • Sallie G. Seay
    • 1
  • Lothar Jennes
    • 1
  • Hyder Jinnah
    • 1
  • Michael Bates
    • 1
  • David Clapper
    • 1
  • Diana Luscher
    • 1
  1. 1.Department of PharmacologyDuke University Medical CenterDurhamUSA

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