Skip to main content
SpringerLink
Log in

Role of Peptides in the Control of Gonadotropin Secretion

  • Chapter
Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis

Part of the book series: Biochemical Endocrinology ((BIOEND))

  • 74 Accesses

Abstract

In this chapter we will review the contributions, particularly from this laboratory, on the control of the gonadotroph by peptides acting at either the hypothalamic or pituitary level. The principal direct control is provided by LHRH which was discovered in 19601 and synthesized in 19712. We will begin by describing the localization of LHRH in the brain, and then move to a discussion of its action on the pituitary gland. This will be followed by an examination of putative synaptic transmitters involved in control of LHRH release which include a variety of monamines and peptides. Most of these mechanisms appear to operate via the intervention of prostaglandin. Finally we will discuss recent evidence indicating the probable existance of a separate FSH- releasing factor.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. McCann, S.M., Taleisnik, S. and Friedman, H.M. (1960) Proc. Soc. Exp. Biol. Med. 104: 432–434.

    CAS  Google Scholar 

  2. Matsuo, H., Baba, Y., Nair, R.M., Arimura, A. and Schally, A.V. (1971) Biochan. Biophys. Res. Comm. 43: 134–139.

    Google Scholar 

  3. Krulich, L., Quijada, M., Wheaton, J.E., Illner, P. and McCann, S.M. (1977) Fed. Proc. 36, 1953–1959.

    PubMed  CAS  Google Scholar 

  4. Barry, J., DuBois, M.P. and Carette, B. (1974) Endocrinology 95, 1416–1423.

    Article  PubMed  CAS  Google Scholar 

  5. Samson, W.K., McCann, S.M., Chud, L., Dudley, C.A. and Moss, R.L. (1980) Neuroendocrinology 31, 66–72.

    Article  PubMed  CAS  Google Scholar 

  6. Phillips, H.S., Hostetter, G., Kerdelhue, B. and Kozlowski, G.P. (1980) Brain Res. 193, 574–579.

    Article  PubMed  CAS  Google Scholar 

  7. Stell, W.K., Chohan, K.S., Lam, D.M. and Kozlowski, G.P. (1982) A.R.V.O. Abstract (in press).

    Google Scholar 

  8. McCann, S.M. (1974) Hand. Physiol. 4, 489–517.

    Google Scholar 

  9. Ojeda, S.R., Andrews, W.W., Advis, J.P. and Smith White, S. (1980) Endocrine Rev. 1, 228–257.

    Article  CAS  Google Scholar 

  10. Mobil, E. (1980) Recent Prog. Horm. Res. 36, 53–88.

    Google Scholar 

  11. Ajika, K., Kalra, S.P., Fawcett, C.P., Krulich, L. and McCann, S.M. (1972) Endocrinology 90, 707–715.

    Article  PubMed  CAS  Google Scholar 

  12. Libertun, C., Orias, R. and McCann, S.M. (1974) Endocrinology 94, 1094–1100.

    Article  PubMed  CAS  Google Scholar 

  13. Fink, G. (1979) Ann. Rev. Physiol. 41, 571–585.

    Article  CAS  Google Scholar 

  14. Goodman, R.L. (1978) Endocrinology 102, 142–150.

    Article  PubMed  CAS  Google Scholar 

  15. Yen, S.S.C. (1977) in Clinical Reproductive Neuroendocrinology, Hubinot, P.O., L’Hermite, M.L. and Robyn, C. ed., Karger, Basel, pp. 150–157.

    Google Scholar 

  16. Libertun, C. and McCann, S.M. (1974) Fed. Proc. 33, 212.

    Google Scholar 

  17. Zeballos, G. and McCann, S.M. (1975) Endocrinology 96, 1377–1385.

    Article  PubMed  CAS  Google Scholar 

  18. Castro Vasquez, A. and McCann, S.M. (1975) Endocrinology 97, 13–19.

    Article  Google Scholar 

  19. Aiyer, M.S., Chiappa, S.A. and Fink, G. (1974) J Endocrinol. 62, 573–588.

    Article  PubMed  CAS  Google Scholar 

  20. Neill, J.D. (1980) Front. Horm. Res. 6, 192–216.

    CAS  Google Scholar 

  21. Wildt, L., Hausler, R., Huchinson, J.S., Marshall, G. and Knobile, E. (1981) Endocrinology 108, 2011–2013.

    Article  PubMed  CAS  Google Scholar 

  22. Pavasuthitaisit, K., Hess, D.L., Norman, R.L., Adams, T.E., Baughman, W.L. and Spies, H.G. (1981) Neuroendocrinoogy 32, 42–49.

    Article  Google Scholar 

  23. Marshall, J.C., Vourne, G.A., Frager, M.S. and Pieper, D.R. (1981) in Functional Correlates of Hormone Receptors in Reproduction, Mahesh, V.B., Muldoon, T.G., Saxena, B.B. and Sadler, W.A. ed., Elsevier/North-Holland, New York, 93–115. 93–115.

    Google Scholar 

  24. Labrie, F., Borgeat, P., Drouin, J., Beaulieu, M., Tagace, L., Ferland, L. and Raymond, V. (1979) Ann. Rev. Physiol. 41, 555–569.

    Article  CAS  Google Scholar 

  25. Naor, A., Syncler, G., Fawcett, C.P. and McCann, S.M. (1978) J. Cyclic Nucleotide Res. 4, 475–486.

    PubMed  CAS  Google Scholar 

  26. Snyder, G., Naor, A., Fawcett, C.P. and McCann, S.M. (1980) Endocrinology 107, 1627–1633.

    Article  PubMed  CAS  Google Scholar 

  27. Naor, Z. and Catt, K.J. (1980) J. Biochem. 225, 342.

    Google Scholar 

  28. McCann, S.M. (1971) in Fronteirs in Neuroendocrinology, Ganong, W.F., and Martini, L., ed., Oxford Press, New York.

    Google Scholar 

  29. Snyder, G. and Bleasdale, J.E. (1982) Mol. Cell. Endocrinol. 28, 55–63.

    Article  PubMed  CAS  Google Scholar 

  30. Michell, R.H. (1975) Biochem. Biophys. Acta 415, 81–447.

    Article  PubMed  CAS  Google Scholar 

  31. Evans, W.S., Hellman, P.H., Uskavitch and Canonico, P.L. (1983) The Program of the 65th Annual Mtg. of the Endocine Society. Abstract #125.

    Google Scholar 

  32. Naor, Z. and Catt, K.J. (1981) J. Biol Chan. 256, 2226–2229.

    CAS  Google Scholar 

  33. Naor, Z., Vanderhoek, J.Y., Lindner, H. R. and Catt, K. J. (1980) In: Advances in Prostaglandin, Thranboxane and Leukotriene Research, eds. Samuelsson, B., Paoleti, R., and Ramwell, P.W. ( Raven, New York ), pp 259–263.

    Google Scholar 

  34. Snyder, G., Capdevila, J., Chacos, N., Manna, S. and Falck, J.R. (1983) Proc. Natl Acad. Sci (USA) 80, 3504–3507.

    Article  CAS  Google Scholar 

  35. Snyder, G., Capdevila, J., Chacos, N. and Falck, J.R. (1983) Program of the 65th Annual Mtg of the Endocrine Society. Abstract #558.

    Google Scholar 

  36. Elde, R. and Hokfelt, T. (1979) Ann. Rev. Physiol. 41, 587–602.

    Article  CAS  Google Scholar 

  37. Schneider, H.P.G. and McCann, S.M. (1969) Endocrinology 85, 121–132.

    Article  PubMed  CAS  Google Scholar 

  38. Fuxe, K. and Hokfelt, T. (1969) in Frontiers in Neuroendocrinology, Ganong, W.F. and Maritni, L. ed., Oxford Press, New York, pp. 47–98.

    Google Scholar 

  39. Schneider, H.P.G. and McCann, S.M. (1970) Endocrinology 86, 1127–1133.

    Article  PubMed  CAS  Google Scholar 

  40. Vijayan, E. and McCann, S.M. (1978) Neuroendocrinology 25, 221–235.

    Article  PubMed  CAS  Google Scholar 

  41. Gnodde, H.P. and Schuiling, G.A. (1976) Neuroendocrinology 20, 212–223.

    Article  PubMed  CAS  Google Scholar 

  42. Negro-Vilar, A., Ojeda, S.R. and McCann, S.M. (1979) Endocrinology 104, 1749–1757.

    Article  PubMed  CAS  Google Scholar 

  43. Vijayan, E. and McCann, S.M. (1978) Neuroendocrinology 25, 150–165.

    Article  PubMed  CAS  Google Scholar 

  44. Ojeda, S.R., Negro-Vilar, A. and McCann, S.M. (1982) Endocrinology 110, 409–412.

    Article  PubMed  CAS  Google Scholar 

  45. Negro-Vilar, A. and Ojeda, S.R. (1982) 64th Ann. Mtg. Endocrine Soc. (submitted).

    Google Scholar 

  46. McCann, S.M., Krulich, L., Ojeda, S.R., Negro-Vilar, A. and Vijayan, E. (1979) in Central Regulation of the Endocrine System, Fuxe, K. Hokfelt, T. and Luft, R. ed., Plenum Press, New York, pp. 329–347.

    Chapter  Google Scholar 

  47. Clifton, D.K. and Sawyer, C.H. (1980) Endocrinology 106, 1099–1102.

    Article  PubMed  CAS  Google Scholar 

  48. Caceres, A. and Taleisnik, S.A. (1980) J. Endocrinol. 87, 419–429.

    Article  PubMed  CAS  Google Scholar 

  49. Huang, X.Y. and McCann, S.M. Proc. Soc. Exp. Biol. & Med. In press.

    Google Scholar 

  50. Petrovic, S.L., McDonald, J.K., Snyder, G.D. and McCann, S.M. (1983) Brain Res. 261: 249–259.

    Article  PubMed  CAS  Google Scholar 

  51. Barraclough, C.A., Wise, P.M., (1982) Endocrine Reviews 3: 91–119.

    Article  PubMed  CAS  Google Scholar 

  52. Advis, J.P., McCann, S.M. and Negro-Vilar, A. (1980) Endocrinology 107, 892–901.

    Article  PubMed  CAS  Google Scholar 

  53. Ojeda, S.R., Negro-Vilar, A. and McCann, S.M. (1981) in Physiopathology of Endocrine Diseases and Mechanisms of Hormone Action, Alan R. Liss, Inc., New York, pp. 229–247.

    Google Scholar 

  54. Ojeda, S.R., Negro Vilar, A. and McCann, S.M. (1979) Endocrinology 104, 617–624.

    Article  PubMed  CAS  Google Scholar 

  55. Ojeda, S.R., Jameson, H.E. and McCann, S.M. (1976) Prostaglandins 12, 281–301.

    Article  PubMed  CAS  Google Scholar 

  56. Schneider, H.P.G. and McCann, S.M. (1970) Endocrinology 86, 1127–1133.

    Article  PubMed  CAS  Google Scholar 

  57. Hery, M., Laplant, E. and Kordon, C. (1976) Endocrinology 99, 496–503.

    Article  PubMed  CAS  Google Scholar 

  58. McCann, S.M., Vijayan, E. and Negro-Vilar, A. (1981) in GABA and Benzodiazepine Receptors, Costa, E., Dichiara, G. and Gessa, G.L. ed., Raven Press, New York, pp. 237–246.

    Google Scholar 

  59. Libertun, C. and McCann, S.M. (1976) Neuroendocrinology 20, 110–120.

    Article  PubMed  CAS  Google Scholar 

  60. Fiorindo, R., Justo, G., Motta, M., Simonovic, I. and Martini, L. (1974) in Hypothalamic Hormones, Motta, M., Crosignani, P. and Martini, L. ed., Academic Press, New York, pp. 195–204.

    Google Scholar 

  61. Vijayan, E. and McCann, S.M. (1980) Brain Res. Bull. 5, 23–29.

    Article  PubMed  CAS  Google Scholar 

  62. Negro Vilar, A., Advis, J.P., Ojeda, S.R. and McCann, S.M. (1982) Endocrinology 111: 932–938.

    Article  Google Scholar 

  63. Soper, B.D. and Weick, R.F. (1980) Endocrinology 106, 348–355.

    Article  PubMed  CAS  Google Scholar 

  64. Sarkar, D.K. and Fink, G. (1981) Endocrinology 108, 862–867.

    Article  PubMed  CAS  Google Scholar 

  65. McCann, S.M., In Neuroendocrine Perspectives, Vol. 1, Muller, E.E. and MacLeod, eds., Elsevier Biomedical Press, Amsterdam, pp. 1–22.

    Google Scholar 

  66. Huang, X.Y. and McCann, S.M., Am. J. Physiol, In Press.

    Google Scholar 

  67. Samson, W.K., Burton, K., Reeves, J.P. and McCann, S.M., (1981) Regulatory Peptides 2: 253–264.

    Article  PubMed  CAS  Google Scholar 

  68. Vijayan, E., Samson, W.K. and McCann, S.M. (1983) Proc. Soc. Exp. Biol. Med. 173: 153–158.

    PubMed  CAS  Google Scholar 

  69. Negro Vilar, A., Samson, W.K. and Sanchez-Franco, F. (1981) Ann. N.Y. Acad. Sci. (sulxnitted )

    Google Scholar 

  70. Steele, M.K., Negro Vilar, A., and McCann, S.M. (1980) Peptides 1, 201–205.

    Article  PubMed  CAS  Google Scholar 

  71. Steele, M.K., Negro-Vilar, A. and McCann, S.M. (1981) Endocrinology 109, 893–899.

    Article  PubMed  CAS  Google Scholar 

  72. Steele, M.K., Negro Vilar, A. and McCann, S.M. (1982) Endocrinology 111: 722–729.

    Article  PubMed  CAS  Google Scholar 

  73. Steele, M.K., Brownfield, M.S., Reid, I.A. and Ganong, W.F. (1982) 64th Ann. Mtg. Endocrine Soc. pg. 1232.

    Google Scholar 

  74. Mukherjee, A., Kulkarni, P., McCann, S.M. and Negro-Vilar, A. (1982) Endocrinology 110, 665–667.

    Article  PubMed  CAS  Google Scholar 

  75. Lumpkin, M.D., Negro Vilar, A., and McCann, S.M. (1981) Science 211, 1072–1074.

    Article  PubMed  CAS  Google Scholar 

  76. Piva, F., Motta, M. and Martini, L. (1979) in Endocrinology, Vol. 1, Degroot, L.J., Cahill, G.F., Martini, L., Nelson, D.H., Odell, W.D., Potts, J.T., Steinberger, E. and Winegrad, A.I. ed., Grune & Stratton, New York, pp. 21–33.

    Google Scholar 

  77. Khorram, O. and McCann, S.M. Endocrinology, In Press.

    Google Scholar 

  78. Hostetter, G., Gallo, R.V. and Brownfield, M.S. (1981) Neuroendocrinology 33, 241–245.

    Article  PubMed  CAS  Google Scholar 

  79. Coutifaris, C. and Chappel, C. (1982) Endocrinology 110, 105–113.

    Article  PubMed  CAS  Google Scholar 

  80. Mangat, H.K. and McCann, S.M. (1983) Am. J. Physiol. 244: E31 - E36.

    PubMed  CAS  Google Scholar 

  81. McCann, S.M., Mizunuma, H., Samson, W.K. and Lumpkin, M.D. Psychoneuroendocrinology (In press).

    Google Scholar 

  82. Mizunuma, H., L.R. DePalatis and S.M. McCann. Neuroendocrinology (in press)

    Google Scholar 

  83. Mizunuma, H., W.K. Samson, M.D. Lumpkin and S.M. McCann. Life Sci., In Press

    Google Scholar 

  84. Samson, W.K., S.I. Said, G. Snyder and S.M. McCann. (1980) Peptides 1: 97–102.

    Article  PubMed  CAS  Google Scholar 

  85. Dhariwal, A.P.S., L. Krulich, S. Katz and S.M. McCann. (1965) Endocrinology 76, 290–294.

    Article  PubMed  CAS  Google Scholar 

  86. Mizunuma, H., W.K. Samson, M.D. Lumpkin, J.H. Moltz, C.P. Fawcett and S.M. McCann (1983) Brain Res. Bull. 10: 623–629.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Texas Health Science Center, 5323 Harry Hines Blvd., Dallas, TX, 75235, USA

    S. M. McCann, G. D. Snyder, S. R. Ojeda, M. D. Lumpkin, A. Ottlecz & W. K. Samson

Authors
  1. S. M. McCann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. D. Snyder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. R. Ojeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. D. Lumpkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Ottlecz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. W. K. Samson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. International Foundation for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

  2. Weizmann Institute of Science, Rehovot, Israel

    Zvi Naor

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

McCann, S.M., Snyder, G.D., Ojeda, S.R., Lumpkin, M.D., Ottlecz, A., Samson, W.K. (1984). Role of Peptides in the Control of Gonadotropin Secretion. In: McKerns, K.W., Naor, Z. (eds) Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9960-5_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-9960-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9962-9

  • Online ISBN: 978-1-4684-9960-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation