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The Regulation of Cell Behavior by Cell Adhesion

  • Paul C. Letourneau
  • Peter N. Ray
  • Merton R. Bernfield
Part of the Biological Regulation and Development book series (BRD, volume 2)

Abstract

The complex morphogenesis of tissues and their successful participation in an organism’s homeostasis depend on regulatory interactions of the tissue cells with their environment. The influence of soluble extrinsic molecules on genetic expression is best illustrated by the powerful effects of hormones. Less well appreciated but also with significant effects on genetic expression are the contacts and physical associations that nearly all cells make with other cells or with extracellular structures. The importance of these associations to cell function is poorly understood, because they are not easily manipulated or assessed in situ, and even when duplicated in vitro one must determine which aspects of cellular contact are regulatory.

Keywords

Cell Adhesion Cell Shape Growth Cone Basal Lamina Contact Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abercombie, M., 1961, The bases of the locomotory behavior of fibroblasts, Exp. Cell Res. Suppl. 8:188.CrossRefGoogle Scholar
  2. Abercrombie, M., 1967, Contact inhibition: The phenomenon and its biological implications, Natl. Cancer Inst. Monogr. 26:249.PubMedGoogle Scholar
  3. Abercrombie, M., and Dunn, G. A., 1975, Adhesions of fibroblasts to substratum during contact inhibition observed by interference reflection microscopy, Exp. Cell Res. 92:57.PubMedCrossRefGoogle Scholar
  4. Abercrombie, M., Heaysman, J. E. M., and Pegnum, 1971, The locomotion of fibroblasts in culture. IV. Electron microscopy of the leading lamella, Exp. Cell Res. 67:359.PubMedCrossRefGoogle Scholar
  5. Abercrombie, M., Dunn, G. A., and Heath, J. P., 1977, The shape and movement of fibroblasts in culture, in: Cell and Tissue Interactions (J. W. Lash and M. M. Burger, eds.), pp. 57–70, Raven Press, New York.Google Scholar
  6. Adler, R., Teitelman, G., and Suburo, A. M., 1976, Cell interactions and the regulation of cholinergic enzymes during neural differentiation in vitro, Dev. Biol. 50:48.PubMedCrossRefGoogle Scholar
  7. Albertini, D. F., and Clark, J. L., 1975, Membrane-microtubule interactions: Concanavalin A capping induced redistribution of cytoplasmic microtubules and colchicine binding proteins, Proc. Natl. Acad. Sci. U.S.A 72:4976.PubMedCrossRefGoogle Scholar
  8. Albrecht-Buehler, G., 1976, Filopodia of spreading 3T3 cells, J. Cell Biol. 69:275.PubMedCrossRefGoogle Scholar
  9. Albrecht-Buehler, G., 1977, Phagokinetic tracks of 3T3 cells: Parallels between the orientation of track segments and of cellular structures which contain actin or tubulin, Cell 12:333.PubMedCrossRefGoogle Scholar
  10. Albrecht-Buehler, G., and Goldman, R. D., 1976, Microspkie mediated particle transport towards the cell body during early spreading of 3T3 cells, Exp. Cell Res. 97:329.PubMedCrossRefGoogle Scholar
  11. Ali, I. U., and Hynes, R. O., 1978, Effects of LETS glycoprotein on cell motility, Cell 14:439.PubMedCrossRefGoogle Scholar
  12. Ali, I. U., Mautner, V., Lanza, R., and Hynes, R. O., 1977, Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein, Cell 11:115.PubMedCrossRefGoogle Scholar
  13. Armstrong, P. B., 1978, Modulation of tissue affinities of cardiac myocyte aggregates by mesenchyme, Dev. Biol. 64:60.PubMedCrossRefGoogle Scholar
  14. Ash, J. F., and Singer, S. J., 1976, Concanavalin A-induced transmembrane linkage of concanavalin A surface receptors to intracellular myosin-containing filaments, Proc. Natl. Acad. Sci. U.S.A. 73:4575.PubMedCrossRefGoogle Scholar
  15. Ash, J. F., Vogt, P. K., and Singer, S. J., 1976, Reversion from transformed to normal pheneotype by inhibition of protein synthesis in rat kidney cells infected with a temperature-sensitive mutant of Rous sarcoma virus, Proc. Natl. Acad. Sci. U.S.A 73:3603.PubMedCrossRefGoogle Scholar
  16. Ashwell, G., 1977, The role of cell-surface carbohydrates in binding phenomena, in: Mammalian Cell Membranes: Membranes and Cellular Functions (G. A. Jamieson and D. M. Robinson, eds.), Vol. 4, pp. 57–71, Butterworths, Boston, Mass.Google Scholar
  17. Ashwell, G., and Morell, A. G., 1974, The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins, Adv. Enzymol. 41:99.PubMedGoogle Scholar
  18. Balsamo, J., and Lilien, J., 1974, The binding of tissue-specific adhesion molecules to the cell surface. A molecular basis for specificity, Biochemistry 14:167.CrossRefGoogle Scholar
  19. Banerjee, S. D., Cohn, R. H., and Bernfield, M. R., 1977, The basal lamina of embryonic salivary epithelia: Production by the epithelium and role in maintaining lobular morphology, J. Cell Biol. 73:445.PubMedCrossRefGoogle Scholar
  20. Barbera, A., 1975, Adhesive recognition between developing retinal cells and the optic tecta of the chick embryo, Dev. Biol. 46:167.PubMedCrossRefGoogle Scholar
  21. Bard, J. B. L., and Hay, E. D., 1975, The behavior of fibroblasts from the developing avian cornea, J. Cell Biol. 67:400.PubMedCrossRefGoogle Scholar
  22. Bard, J. B. L., Hay, E. D., and Meller, S. M., 1975, Formation of the endothelium of the avian cornea: A study of cell movement in vivo, Dev. Biol. 42:334.PubMedCrossRefGoogle Scholar
  23. Barondes, S. H., and Rosen, S. D., 1976, Cell surface carbohydrate-binding proteins: Role in cell recognition, in: Neuronal Recognition (S. H. Barondes, ed.), pp. 331–356, Plenum Press, New York.CrossRefGoogle Scholar
  24. Bell, G. I., 1978, Models for the specific adhesion of cells to cells, Science 200:618.PubMedCrossRefGoogle Scholar
  25. Bell, P. B., 1977, Locomotory behavior, contact inhibition, and pattern formation of 3T3 and polyoma virustransformed 3T3 cells in culture, J. Cell Biol. 74:963.PubMedCrossRefGoogle Scholar
  26. Benecke, B. J., Ben-Ze’ev, A., and Penman, S., 1978, The control of mRNA production, translation and turnover in suspended and reattached anchorage-dependent fibroblasts, Cell 14:931.PubMedCrossRefGoogle Scholar
  27. Bernfield, M. R., and Banerjee, S. D., 1972, Acid mucopolysaccharide (glycosaminoglycan) at the epithelial-mesenchymal interface of mouse embryo salivary glands, J. Cell Biol. 52:664.PubMedCrossRefGoogle Scholar
  28. Bernfield, M. R., Cohn, R. H., and Banerjee, S. D., 1973, Glycosaminoglycans and epithelial organ formation, Am. Zool. 13:1067.Google Scholar
  29. Bischoff, R., and Holtzer, H., 1969, Mitosis and the process of differentiation of myogenic cells in vitro, J. Cell Biol. 41:188.PubMedCrossRefGoogle Scholar
  30. Blomberg, F., Cohen, R. S., and Siekevitz, P., 1977, The structure of postsynaptic densities isolated from dog cerebral cortex, J. Cell Biol. 74:204.PubMedCrossRefGoogle Scholar
  31. Bornstein, M. B., 1958, Reconstituted rat-tail collagen used as a substrate for tissue cultures on coverslips in Maximow slides and roller tubes, Lab. Invest. 7:134.PubMedGoogle Scholar
  32. Bornstein, P., and Ash, J. F., 1977, Cell surface-associated structural proteins in connective tissue cells, Proc. Natl. Acad. Sci. U.S.A 74:2480.PubMedCrossRefGoogle Scholar
  33. Bourguignon, L. Y. W., and Songer, S. J., 1977, Transmembrane interactions and the mechanism of capping of surface receptors by their specific ligands, Proc. Natl. Acad. Sci. U.S.A 74:5031.PubMedCrossRefGoogle Scholar
  34. Bragina, E. E., Vasiliev, J. M., and Gelfand, I. M., 1976, Formation of bundles of microfilaments during spreading of fibroblasts on the substrate, Exp. Cell Res. 97:241.PubMedCrossRefGoogle Scholar
  35. Bray, D., 1970, Surface movements during the growth of single explanted neurons, Proc. Natl. Acad. Sci. U.S.A 65:905.PubMedCrossRefGoogle Scholar
  36. Bray, D., 1973, Model for membrane movements in the neural growth cone, Nature (London) 244:93.CrossRefGoogle Scholar
  37. Bray, D., Thomas, C., and Shaw, G., 1978, Growth cone formation in cultures of sensory neurons, Proc. Natl. Acad. Sci. U.S.A 75:5226.PubMedCrossRefGoogle Scholar
  38. Brown, S. S., and Revel, J. P., 1976, Reversibility of cell surface label rearrangement, J. Cell Biol. 68:629.PubMedCrossRefGoogle Scholar
  39. Brunk, U., Ericsson, J. L. E., Ponten, J., and Westermark, B., 1971, Specialization of cell surfaces in contactinhibited human glia-like cells in vitro, Exp. Cell Res. 67:407.PubMedCrossRefGoogle Scholar
  40. Capers, C. R., 1960, Multinucleation of skeletal muscle in vitro, J. Biophys. Biochem. Cytol. 7:559.PubMedCrossRefGoogle Scholar
  41. Carney, D. H., and Cunningham, D. D., 1978, Cell surface action of thrombin is sufficient to intiate division of chick cells, Cell 14:811.PubMedCrossRefGoogle Scholar
  42. Carney, D. H., Glenn, K. S., and Cunningham, D. D., 1978, Conditions which affect initiation of animal cell division by trypsin and thrombin, J. Cell. Physiol. 95:13.PubMedCrossRefGoogle Scholar
  43. Carter, S. B., 1965, Principles of cell motility and the directionality of cell movement and cancer invasion, Nature (London) 208:1183.CrossRefGoogle Scholar
  44. Cassiman, J. J., and Bernfield, R. R., 1975, Transformation induced alterations in fibroblast adhesion: Masking by trvpsin treatment, Exp. Cell Res. 91:31.PubMedCrossRefGoogle Scholar
  45. Cassiman, J. J., and Bernfield, M. R., 1976a, Transformation-induced alterations in adhesion: Binding of preformed aggregates to call layers, Exp. Cell Res. 103:311.PubMedCrossRefGoogle Scholar
  46. Cassiman, J. J., and Bernfield, M. R., 1976b, Intercellular adhesive recognition: Tissue specific differences and membrane site mobility, Dev. Biol. 52:231.PubMedCrossRefGoogle Scholar
  47. Chen L. B. 1977. Alterations in cell surface LETS protein during myogenesis, Cell 10:393.PubMedCrossRefGoogle Scholar
  48. Chen, L. B., Murray, A., Segal, R. A., Bushnell, A., and Walsh, M. L., 1978, Studies on intercellular LETS glycoprotein matrices, Cell 14:377.PubMedCrossRefGoogle Scholar
  49. Chen, W. T., 1977, Retraction of the trailing edge during fibroblast movement, J. Cell Biol. 75:416a.Google Scholar
  50. Chen, W. T., 1978, Induction of spreading during fibroblast movement, J. Cell Biol. 79:83a.CrossRefGoogle Scholar
  51. Chen, W. T., 1979, Change in arrangement of cortical microfilaments associated with change in cell locomotor activity, Biophys. J. 25:A32.Google Scholar
  52. Cohn, R. H., Cassiman, J. J., and Bernfield, M. R. 1976, Relationship of tranformation, cell density, and growth control to the cellular distribution of newly synthesized glycosaminoglycan, J. Cell Biol. 71:280.PubMedCrossRefGoogle Scholar
  53. Cohn, R. H., Banerjee, S. D. and Bernfield, M. R., 1977, Basal lamina of embryonic salivary epithelia, J. Cell Biol. 73:464.PubMedCrossRefGoogle Scholar
  54. Collett, M. S., and Erikson, R. L., 1978, Protein kinase activity associated with the avian sarcoma virus src gene product, Proc. Natl. Acad. Sci. U.S.A. 75:2021.PubMedCrossRefGoogle Scholar
  55. Collins, F., 1978a, Axon initiation by ciliary neurons in culture, Dev. Biol. 65:50.PubMedCrossRefGoogle Scholar
  56. Collins, F., 1978b, Induction of neurite outgrowth by a conditioned-medium factor bound to the culture substratum, Proc. Natl. Acad. Sci. U.S.A. 75:5210.PubMedCrossRefGoogle Scholar
  57. Cooper, W. G, and Konigsberg, R. I., 1961, Dynamics of myogenesis in vitro, Anat. Rec. 140:195.PubMedCrossRefGoogle Scholar
  58. Culp, L. A., 1974, Substrate-attached glycoproteins mediating adhesion of normal and virus-transformed mouse fibroblasts, J. Cell Biol. 63:71.PubMedCrossRefGoogle Scholar
  59. Culp, L. A., 1978, Biochemical determinants of cell adhesion, in: Current Topics in Membranes and Transport: Cell Surface Glycoproteins (R. L. Juliano and A. Rothstein, eds.), Vol XI, pp. 327–396, Academic Press, New York.Google Scholar
  60. Culp, L. A., and Buniel, J. F., 1976, Substrate-attached serum and cell proteins in adhesion of mouse fibroblasts, J. Cell. Physiol. 88:89.PubMedCrossRefGoogle Scholar
  61. Culp, L. A., Rollins, B. J., Buniel, J., and Hitri, S., 1978, Two functionally distinct pools of glycosaminoglycan in the substrate adhesion site of murine cells, J. Cell Biol. 79:788.PubMedCrossRefGoogle Scholar
  62. Curtis, A. S. G., 1964, The mechanism of adhesion of cells to glass. A study by interference reflection microscopy, J. Cell Biol. 20:199.PubMedCrossRefGoogle Scholar
  63. Curtis, A. S. G., 1973, Cell Adhesion, Prog. Biophys. Mol. Biol. 27:315.CrossRefGoogle Scholar
  64. Damsky, C. H., Wylie, D. E., and Buck, C. A., 1979, Studies on the function of cell surface glycoproteins. II. Possible role of surface glycoproteins in the control of cytoskeletal organization and surface morphology, J. Cell Biol. 80:403.PubMedCrossRefGoogle Scholar
  65. David, G., and Bernfield, M. R., 1979, Collagen reduces glycosaminoglycan degradation by cultured mammary epithelial cells: Possible mechanism for basal lamina formation, Proc. Natl. Acad. Sci. U.S.A. 76:786.PubMedCrossRefGoogle Scholar
  66. Den, H., Malinzak, D. A., and Rosenberg, A., 1976, Lack of evidence for the involvement of a β-D-galactosylspecific lectin in the fusion of chick myoblasts, Biochem. Biophys. Res. Commun. 69:621.PubMedCrossRefGoogle Scholar
  67. Derby, M. A., 1978, Analysis of glycosaminoglycans within the extracellular environments encountered by migrating neural crest cells, Dev. Biol. 66:321.PubMedCrossRefGoogle Scholar
  68. Dessau, W., Sasse, J., Timpl, R., Jilek, F., von der Mark, K., 1978, Synthesis and extracellular deposition of fibronectin in chondrocyte cultures, J. Cell Biol. 79:342.PubMedCrossRefGoogle Scholar
  69. DiPasquale, A., 1975a, Locomotory activity of epithelial cells in culture, Exp. Cell Res. 94:191.PubMedCrossRefGoogle Scholar
  70. DiPasquale, A., 1975a, Locomotion of epithelial cells, Exp. Cell Res. 95:425.PubMedCrossRefGoogle Scholar
  71. DiPasquale, A., and Bell, P. B., Jr., 1974, The upper cell surface: Its inability to support active cell movement in culture, J. Cell Biol. 62:198.PubMedCrossRefGoogle Scholar
  72. Domnina, L. V., Pletyushkina, O. Y., Vasiliev, J. M., and Gelfand, I. M., 1977, Effects of antitubulins on the redistribution of crosslinked receptors on the surface of fibroblasts and epithelial cells, Proc. Natl. Acad. Sci. U.S.A. 74:2865.PubMedCrossRefGoogle Scholar
  73. Douvas, A. S., Harrington, C. A., and Bonner, J., 1975, Major nonhistone proteins of rat liver chromatin: Preliminary identification of myosin, actin, tubulin and tropomyosin, Proc. Natl. Acad. Sci. U.S.A. 72:3902.PubMedCrossRefGoogle Scholar
  74. Dulap, M. K., and Donaldson, D. J., 1978, Inability of colchicine to inhibit newt epidermal cell migration or prevent concanavalin A-mediated inhibition of migration, Exp. Cell Res. 116:15.CrossRefGoogle Scholar
  75. Dunn, G. A., and Ebenbal, T., 1978, Some aspects of contact guidance, Zoon 6:65.Google Scholar
  76. Dunn, G. A., and Heath, J. P., 1976, A new hypothesis of contact guidance in tissue cells, Exp. Cell Res. 101:1.PubMedCrossRefGoogle Scholar
  77. Ebendal, T., 1977, Extracellular matrix fibrils and cell contacts in the chick embryo, Cell Tiss. Res. 175:439.Google Scholar
  78. Edelman, G. M., 1976, Surface modulation in cell recognition and cell growth, Science 192:218.PubMedCrossRefGoogle Scholar
  79. Edelman, G. M., and Yahara, I., 1976, Temperature-sensitive changes in surface modulating assemblies of fibroblasts transformed by mutants of Rous sarcoma virus, Proc. Natl. Acad. Sci. U.S.A. 73:2047.PubMedCrossRefGoogle Scholar
  80. Edwards, J. G., 1977, Cell adhesion, in: Mammalian Cell Membranes: Membranes and Cellular Functions (G. A. Jamieson and D. M. Robinson, eds.), Vol. 4, pp. 32–56, Butterworths, Boston, Mass.Google Scholar
  81. Emerman, J. T., and Pitelka, D. R., 1977, Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes, In Vitro 13:316.CrossRefGoogle Scholar
  82. Emerman, J. T., Enami, J., Pitelka, D. R., and Nandi, S., 1977, Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes, Proc. Natl. Acad. Sci. U.S.A. 74:4466.PubMedCrossRefGoogle Scholar
  83. Engvall, E., and Ruoslahti, E., 1977, Binding of soluble form of fibroblast surface protein, fibronectin, to collagen, Int. J. Cancer 20:1.PubMedCrossRefGoogle Scholar
  84. Erickson, C. A., 1978, Contact behavior and pattern formation of BHK and polyoma virus-transformed BHK fibroblasts in culture, J. Cell Sci. 33:53.PubMedGoogle Scholar
  85. Erickson, C. A., and Trinkaus, 1976, Microvilli and blebs as sources of reserve surface membrane during cell spreading, Exp. Cell Res. 99:375.PubMedCrossRefGoogle Scholar
  86. Fantes, P. A., Grant, W. D., Pritchard, R. H., Sudbery, P. E., and Wheals, A. E., 1975, The regulation of cell size and the control of mitosis, J. Theor. Biol. 50:213.CrossRefGoogle Scholar
  87. Farmer, S. R., Ben-Ze’ev, A., Benecke, B. J., and Penman, S., 1978, Altered translatability of messenger RNA from suspended anchorage-dependent fibroblasts: Reversal upon cell attachment to a surface, Cell 15:627.PubMedCrossRefGoogle Scholar
  88. Fear, J., 1977, Observations on the fusion of chick embryo myoblasts in culture, J. Anat. 124:437.PubMedGoogle Scholar
  89. Fischbach, G. D., 1970, Synaptic potentials recorded in cell cultures of nerve and muscle, Science 169:1331.PubMedCrossRefGoogle Scholar
  90. Fischer, E. H., Becker, J. U., Blum, H. E., Lehky, P., Malencik, D. A., and Pocinwong, S., 1975, Concerted regulation of carbohydrate metabolism and muscle contraction, Hoppes-Seylers Z. Physiol. Chem. 356:381.Google Scholar
  91. Fischman, D. A., 1972, in: The Structure and Function of Muscle, Vol. 1 (G. H. Bourne, ed.), Academic Press, New York.Google Scholar
  92. Fleischer, M., and Wohlfarth-Botterman, K. E., 1975, Correlation between tension force generation, fibrillogenesis and ultrastructure of cytoplasmic actomyosin during isometric and isotonic contractions of protoplasmic strands, Cytobiologie 10:339.Google Scholar
  93. Folkman, J., 1977, Conformational control of cell and tumor growth, in: Recent Advances in Cancer Research: Cell Biology, Molecular Biology and Tumor Virology, Vol. 1 (R. C. Gallo, ed.), CRC, Cleveland, Ohio.Google Scholar
  94. Folkman, J., and Greenspan, H. P., 1975, Influence of geometry on control of cell growth, Biochem. Biophys. Acta 417:211.PubMedGoogle Scholar
  95. Folkman, J., and Moscona, A., 1978, Role of cell shape in growth control, Nature (London) 273:345.CrossRefGoogle Scholar
  96. Frazier, W., and Glaser, L., 1979, Cell surface components involved in cell recognition, Annu. Rev. Biochem. 48:491.PubMedCrossRefGoogle Scholar
  97. Friedlander, M., and Fischman, D. A., 1975, Serological analysis of developing muscle cell surfaces, J. Cell Biol. 67:124a.Google Scholar
  98. Furcht, L. T., Mosher, D., and Wendelschafer-Crabb, G., 1977, Immunoelectron microscopic localization of fibronectin during myogenesis, J. Cell Biol. 75:156a.Google Scholar
  99. Furukawa, K., and Terayama, H., 1977, Isolation and identification of glycosaminoglycans associated with purified nuclei from rat liver, Biochem. Biophys. Acta 499:278.PubMedCrossRefGoogle Scholar
  100. Gail, M., 1973, Time lapse studies on the motility of fibroblasts in tissue culture, Ciba Found. Symp. 14 (N. S.):287.PubMedGoogle Scholar
  101. Gail, M. H., and Boone, C. W., 1972, Cell-substrate adhesivity, Exp. Cell Res. 70:33.PubMedCrossRefGoogle Scholar
  102. Gartner, T. K., and Podleski, T. R., 1975, Evidence that a membrane bound lectin mediates fusion of L6 myoblasts, Biochem. Biophys. Res. Commun. 67:972.PubMedCrossRefGoogle Scholar
  103. Gartner, T. K., and Podleski, T. R., 1976, Evidence that the types and specific activity of lectins control fusion of L6 myoblasts, Biochem. Biophys. Res. Commun. 70:1142.PubMedCrossRefGoogle Scholar
  104. Glabe, C. G., and Vacquier, V. D., 1977, The surfaces of sea urchin eggs possess a species-specific receptor for binding, J. Cell Biol. 75:56a.CrossRefGoogle Scholar
  105. Goldberg, B., 1979, Binding of soluble type I collagen molecules to the fibroblast plasma membrane, Cell 16:265.PubMedCrossRefGoogle Scholar
  106. Goldman, R. D., Yerna M. J., and Schloss, J. A., 1976, Localization and organization of microfilaments and related proteins in normal and virus-transformed cells, J. Supramol. Struct. 5:155.PubMedCrossRefGoogle Scholar
  107. Gospodarowicz, D., Greenberg, G., and Birdwell, C. R., 1978, Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth, Can. Res. 38:4155.Google Scholar
  108. Gottlieb, D. I., Merrell, R., and Glaser, L., 1974, Temporal changes in embryonic cell surface recognition, Proc. Natl. Acad. Sci. U.S.A 71:1800.PubMedCrossRefGoogle Scholar
  109. Gottlieb, D. I., Rock, K., and Glaser, L., 1976, A gradient of adhesive specificity in developing avian retina, Proc. Natl. Acad. Sci. U.S.A 73:410.PubMedCrossRefGoogle Scholar
  110. Graham, J. M., Hynes, R. O., Davidson, E. A., and Bainkon, D. F., 1975, The location of proteins labeled by the 125I-lactoperoxidase system in the NIL 8 hamster fibroblast, Cell 4:353.PubMedCrossRefGoogle Scholar
  111. Greulich, R. C., and Slavkin, H. C. (eds.), 1975, Extracellular Matrix Influences on Gene Expression, Academic Press, New York.Google Scholar
  112. Grinnell, F., 1978, Cellular adhesiveness and extracellular substrata, Int. Rev. Cytol. 29:65.CrossRefGoogle Scholar
  113. Grinnell, F., and Minter, D., 1978, Attachment and spreading of baby hamster kidney cells to collagen substrata. Effects of cold-insoluble globulin, Proc. Natl. Acad. Sci. U.S.A 75:4408.PubMedCrossRefGoogle Scholar
  114. Harris, A., 1973a, Behavior of cultured cells on substrata of variable adhesiveness, Exp. Cell Res. 77:285.PubMedCrossRefGoogle Scholar
  115. Harris, A., 1973b, Cell surface movements related to cell locomotion, Ciba Found. Symp. 14 (N. S.):3.PubMedGoogle Scholar
  116. Harris, A., 1973c, Location of cellular adhesions to solid substrata, Dey. Biol. 35:83.CrossRefGoogle Scholar
  117. Harris, A. J., Heinemann, S., Schubert, C., and Tarakis, H., 1971, Trophic interactions between cloned tissue culture lines of nerve and muscle, Nature (London) 231:296.CrossRefGoogle Scholar
  118. Hauschka, S. D., 1972, in: Growth, Nutrition and Metabolism of Cells in Culture, Vol. 2 (G. H. Rothblat and V. J. Cristofalo, eds.), pp. 67–130, Academic Press, New York.Google Scholar
  119. Hauschka, S. D., and Konigsberg, I. R., 1966, The influence of collagen on developing muscle clones, Proc. Natl. Acad. Sci. U.S.A 55:119.PubMedCrossRefGoogle Scholar
  120. Hay, E. D, 1973, Origin and role of collagen in the embryo, Am. Zool. 13:1085.Google Scholar
  121. Heath, J. P., and Dunn, G. A., 1978, Cell to substratum contacts of chick fibroblasts and their relation to the microfilament system, J. Cell Sci. 29:197.PubMedGoogle Scholar
  122. Heaysman, J., 1973, Ciba Found. Symp. 14 (N. S.):187–194.Google Scholar
  123. Hedman, K., Vaheri, A., and Wartiovaara, J., 1978, External fibronectin of cultured human fibroblasts in predominantly a matrix protein, J. Cell Biol. 76:748.PubMedCrossRefGoogle Scholar
  124. Henkart, P., Humphreys, S., Humphreys, T., 1973, Characterization of sponge aggregation factor: A unique proteoglycan complex, Biochemistry 12:3045.PubMedCrossRefGoogle Scholar
  125. Hitchcock, S. E., Carlsson, L., and Lindberg, U., 1976, Depolymerization of F-actin by deoxyribonuclease I, Cell 7:531.PubMedCrossRefGoogle Scholar
  126. Holley, R. W., 1975, Control of growth of mammalian cells in cell culture, Nature (London) 258:487.CrossRefGoogle Scholar
  127. Holtzer, H., Weintraub, H., Mayne R., and Mochan, B., 1972, The cell cycle, cell lineages and cell differentiation, Curr. Top. Dev. Biol. 7:229.PubMedCrossRefGoogle Scholar
  128. Holtzer, H., Rubinstein, N., Dienstman, S., Chi, J., Biehl, J., and Somlye, A., 1974, Perspectives in myogenesis, Biochimie 56:1575.PubMedCrossRefGoogle Scholar
  129. Holtzer, H., Rubinstein, N., Fellini, S., Yeoh, G., Chi, J., Birnbaum, J., and Okayama, M., 1975, Lineages, quantal cell cycles, and the generation of cell diversity, Q. Rev. Biophys. 8:523.PubMedCrossRefGoogle Scholar
  130. Hoover, R. L., Briggs, R. T., and Karnovsky, M. J., 1978, The adhesive interaction between polymorphonuclear leukocytes and endothelial cells in vitro, Cell 14:423.PubMedCrossRefGoogle Scholar
  131. Huxley, H. E., 1973, Muscular contraction and cell motility, Nature (London) 243:445.CrossRefGoogle Scholar
  132. Hynes, R. O., 1976, Cell surface proteins and malignant transformation, Biochim. Biophys. Acta 458:73.PubMedGoogle Scholar
  133. Hynes, R. O., and Destree, A. T., 1978, Relationships between fibronectin (LETS protein) and actin, Cell 15:875.PubMedCrossRefGoogle Scholar
  134. Ingram, V. M., 1969, A side view of moving fibroblasts, Nature (London) 222:641.CrossRefGoogle Scholar
  135. Isenberg, G., Rathke, P. C., Hulsmann, N., Franke, W. W., and Wohlfarth-Bottermann, K. E., 1976, Cytoplasmic actomyosin fibrils in tissue culture cells. Direct proof of contractility by visualization of ATPinduced contraction in fibrils isolated by laser microbeam dissection, Cell Tissue Res. 166:427.PubMedCrossRefGoogle Scholar
  136. Izzard, C. S., and Lochner, L. R., 1976, Cell-to-substrate contacts in living fibroblasts: An interference reflection study with an evaluation of the technique, J. Cell Sci. 21:129.PubMedGoogle Scholar
  137. Jacobson, M., 1970, Developmental Neurobiology, Holt, Rinehart, and Winston, San Francisco, Calif.Google Scholar
  138. Ji, T. H., and Nicolson, G., 1974, Lectin binding and perturbation of the outer surface of the cell membrane induces a transmembrane organization alteration at the inner surface, Proc. Natl. Acad. Sci. U.S.A 71:2212.PubMedCrossRefGoogle Scholar
  139. Johnson, K. E., 1970, The role of changes in cell contact behavior in amphibian gastrulation, J. Exp. Zool. 175:391.PubMedCrossRefGoogle Scholar
  140. Keski-Oja, J., Mosher, D. F., and Vaheri, A., 1977, Dimeric character of fibronectin, a major cell surfaceassociated glycoprotein, Biochem. Biophys. Res. Commun. 74:699.PubMedCrossRefGoogle Scholar
  141. Knudson, K. A., and Horwitz, A. F., 1977a, Tandem events in myoblast fusion, Dey. Biol. 58:328.CrossRefGoogle Scholar
  142. Knudson, K. A., and Horwitz, A. F., 1977b, Tandem events in myoblast fusion, J. Supramol. Struct. 1977(51):39.Google Scholar
  143. Koch, G. L. E., and Smith, M. J., 1978, An association between actin and the major histocompatibility antigen H-2, Nature (London) 273:274.CrossRefGoogle Scholar
  144. Koda, L. Y., and Partlow, L. M., 1976, Membrane marker movement on sympathetic axons in tissue culture, J. Neurobiol. 7:157.PubMedCrossRefGoogle Scholar
  145. Konigsberg, I. R., 1963, Clonal analysis of myogenesis, Science 140:1273.PubMedCrossRefGoogle Scholar
  146. Kongisberg, I. R., 1970, The relationship of collagen to the clonal development of embryonic skeletal muscle, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 3 (E. A. Balazs, ed.), p. 1779, Academic Press, New York.Google Scholar
  147. Konigsberg, I. R., 1971, Diffusion-mediated control of myoblast fusion, Dev. Biol. 26:133.PubMedCrossRefGoogle Scholar
  148. Konigsberg, I. R., and Hauschka, S. D., 1965, Cell and tissue interactions in the reproduction of cell type, Symp . Soc. Devel. Biol. 24:243.Google Scholar
  149. Kraemer, P. M., and Tobey, R. A., 1972, Cell-cycle dependent desquamation of heparan sulfate from the cell surface, J. Cell Biol. 55:713.PubMedCrossRefGoogle Scholar
  150. Krawczyk, W. S., 1971, A pattern of epidermal cell migration during wound healing, J. Cell Biol. 49:247.PubMedCrossRefGoogle Scholar
  151. Kurikenin, M., Wartiovaara, J., and Vaheri, A., 1978, Cytochalasin B releases a major surface-associated glycoprotein, fibronectin, from cultured fibroblasts, Exp. Cell Res. 111:127.CrossRefGoogle Scholar
  152. Lazarides, E., 1976, Two general classes of cytoplasmic actin filaments in tissue culture cells: The role of tropmyosin, J. Supramol. Struct. 5:531.PubMedCrossRefGoogle Scholar
  153. LeDouarin, N., 1976, Cell migration in early vertebrate development studied in interspecific chimeras, Ciba Found. Symp. 40:71.Google Scholar
  154. LeDouarin, N., and Teillet, M. A. M., 1974, Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neuroectodermal mesenchymal derivatives, using a biological cell marking technique, Dev. Biol. 41:162.CrossRefGoogle Scholar
  155. Lenk, R., and Penman, S., 1979, The cytoskeletal framework and polio virus metabolism, Cell 16:289.PubMedCrossRefGoogle Scholar
  156. Letourneau, P. C., 1975a, Possible rolles for cell-to-cell substratum adhesion in neuronal morphogenesis, Dev. Biol. 44:77.PubMedCrossRefGoogle Scholar
  157. Letourneau, P. C., 1975b, Cell-to-substratum adhesion and guidance of axonal elongation, Dev. Biol. 44:92.PubMedCrossRefGoogle Scholar
  158. Letourneau, P. C., 1977, Regulation of neuronal morphogenesis by cell-substratum adhesion, Soc. Neurosci. Symp. 2:67.Google Scholar
  159. Letourneau, P. C., 1979a, Inhibition of cell adhesion by concanavalin A is associated with Con A-mediated rearrangements of surface receptors, J. Cell Biol. 80:128.PubMedCrossRefGoogle Scholar
  160. Letourneau, P. C., 1979b, Cell-substratum adhesion of neurite growth areas, Exp. Cell Res. 124:127.PubMedCrossRefGoogle Scholar
  161. Letourneau, P. C., and Wessells, N. K., 1974, Migratory cell locomotion versus nerve axon elongation. Differences based on the effects of lanthanum ion, J. Cell Biol. 61:56.PubMedCrossRefGoogle Scholar
  162. Leung, J. P., Trotter, J. A., Munar, E., and Nameroff, M., 1975, Differentiation of the myogenic cell surface in: ICN-UCLA Symposium on Molecular and Cellular Biology, Vol. 2 (D. McMahon and D. F. Fox, eds.), W. A. Benjamin Co., Menlo Park, Calif.Google Scholar
  163. Linder, E., Vaheri, A., Ruoslahti, E., and Wartiovaara, J., 1975, Distribution of fibroblast surface antigen in the developing chick embryo, J. Exp. Med. 142:41.PubMedCrossRefGoogle Scholar
  164. Linsenmeyer, T., Gibney, E., Toole, B. P., and Gross, J., 1978, Cellular adhesion to collagen, Exp. Cell Res. 116:470.CrossRefGoogle Scholar
  165. Lipton, B. H., 1977, Collagen synthesis by normal and bromodeoxyuridine-modulated cells in myogenic culture, Dev. Biol. 61:153.PubMedCrossRefGoogle Scholar
  166. Lopresti, V., Macagno, E. R., and Levinthal, C., 1973, Structure and development of neural connections in isogenic organisms: Cellular interactions in the development of the optic lamina of Daphnia, Proc. Natl. Acad. Sci. U.S.A 70:433.PubMedCrossRefGoogle Scholar
  167. Luduena-Anderson, M. A., 1973, Nerve cell differentiation in vitro, Dev. Biol. 33:268.CrossRefGoogle Scholar
  168. Luduena-Anderson, M., and Wessells, N. K., 1973, Cell locomotion, nerve elongation, and microfilaments, Dev. Biol. 30:427.CrossRefGoogle Scholar
  169. McClay, D., and Baker, S. R., 1975, A kinetic study of cell adhesion, Dev. Biol. 43:109.PubMedCrossRefGoogle Scholar
  170. McClay, D. R., Gooding, L. R., and Fransen, M. E., 1977, A requirement for trypsin-sensitive cell-surface components for cell-cell interactions of embryonic neural retina cells, J. Cell Biol. 75:56.PubMedCrossRefGoogle Scholar
  171. McEvoy, F. A., and Ellis, D. E., 1976, Incorporation of 14C-palmitate into the lipids of cultured chick embryo myoblasts, Biochem. Soc. Trans. 4:1065.PubMedGoogle Scholar
  172. McGuire, E. J., and Burdick, C. L., 1976, Intercellular adhesive selectivity. I. An improved assay for the measurement of embryonic chick intercellular adhesion (liver and other tissues), J. Cell Biol. 68:80.PubMedCrossRefGoogle Scholar
  173. MacPherson, I., and Montagnier, L., 1964, Agar suspension culture for the selective assay of cells transformed by polyoma virus, Virology 23:291.PubMedCrossRefGoogle Scholar
  174. Manasek, F. J., 1975, The extracellular matrix: A dynamic component of the developing embryo, Curr. Top. Dev. Biol. 10:35.PubMedCrossRefGoogle Scholar
  175. Marchase, R. B., 1977, Biochemical investigations of retino-tectal adhesive specificity, J. Cell Biol. 75:237.PubMedCrossRefGoogle Scholar
  176. Marchase, R. B., Vosbeck, K., and Roth, S., 1976, Intercellular adhesive specificity, Biochem. Biophys. Acta 457:385.PubMedCrossRefGoogle Scholar
  177. Maroudas, N. G., 1972, Anchorage dependence: Correlation between amount of growth and diameter of bead, for single cells grown on individual glass beads, Exp. Cell Res. 75:337.CrossRefGoogle Scholar
  178. Maroudas, N. G., 1973, Chemical and mechanical requirements for fibroblast adhesion, Nature (London) 244:353.CrossRefGoogle Scholar
  179. Marshall, L. M., Sanes, J. R., and McMahon, U. J., 1977, Reinnervation of original synaptic sites on muscle fiber basement membrane after disruption of the muscle cells, Proc. Natl. Acad. Sci. U.S.A 74:3073.PubMedCrossRefGoogle Scholar
  180. Martin, G. R., and Rubin, H., 1974, Effects of cell adhesion of the substratum on the growth of chick embryo fibroblasts, Exp. Cell Res. 85:319.PubMedCrossRefGoogle Scholar
  181. Maslow, D. E, 1967, The formation of multinucleated striated muscle, Am. Zool. 7:751.Google Scholar
  182. Maslow, D. E., 1969, Cell specificity in the formation of multinucleated striated muscle, Exp. Cell Res. 54:381.PubMedCrossRefGoogle Scholar
  183. Mautner, V., and Hynes, R. O., 1977, Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed cells, J. Cell Biol. 75:743.PubMedCrossRefGoogle Scholar
  184. Medoff, J., and Gross, J., 1971, in vitro aggregation of mixed embryonic kidney and nerve cells, J. Cell Biol. 50:457.PubMedCrossRefGoogle Scholar
  185. Merlie, J. P., Buckingham, M. E., and Whalen, R. G., 1977, Molecular aspects of myogenesis, Curr. Top. Dev. Biol. 11:61.PubMedCrossRefGoogle Scholar
  186. Michalopoulos, G., and Pitot, H. C., 1975, Primary culture of parenchymal liver cells on collagen membranes, Exp. Cell Res. 94:70.PubMedCrossRefGoogle Scholar
  187. Middleton, C. A., 1977, The effects of cell—cell contact on the spreading of pigmented retina epithelial cells in culture, Exp. Cell Res. 109:349.PubMedCrossRefGoogle Scholar
  188. Mooseker, M. S., 1976, Actin filament—membrane attachment in the microvilli of intestinal epithelial cells, in: Cell Motility (G. Goldman, T. Pollard and J. Rosenbaum, eds.), pp. 631–650, Cold Spring Harbor Laboratory, New York.Google Scholar
  189. Moscona, A. A., 1974, Surface specification of embryonic cells: Lectin receptors, cell recognition, and specific cell ligands, in: The Cell Surface in Development (A. A. Moscona, ed.), pp. 67–100, Wiley, New York.Google Scholar
  190. Moyer, W. A., and Steinberg, M. S., 1976, Do rates of intercellular adhesion measure the cell affinities reflected in cell-sorting and tissue-spreading configurations? Dev. Biol. 52:246.PubMedCrossRefGoogle Scholar
  191. Muller, K., and Gerisch, G., 1978, A specific glycoprotein as the target site of adhesive blocking Fab in aggregating Dictyostelium cells, Nature (London) 274:445.CrossRefGoogle Scholar
  192. Murray, J. C, Stingl, G., Kleinman, H. K., Martin, G. R., and Katz, S. I., 1979, Epidermal cells adhere preferentially to type IV (basement membrane) collagen, J. Cell Biol. 80:197.PubMedCrossRefGoogle Scholar
  193. Nakajima, S., 1965, Selectivity in fasciculation of nerve fibers in vitro, J. Comp. Neurol. 125:193.PubMedCrossRefGoogle Scholar
  194. Nameroff, M., and Munar, E., 1976, Inhibition of cellular differentiation by phospholipase C, Dev. Biol. 49:288.PubMedCrossRefGoogle Scholar
  195. Nelson, G. A., and Revel, J. P., 1975, Scanning electron microscope study of cell movements in the corneal endothelium of the avian embryo, Dev. Biol. 42:315.PubMedCrossRefGoogle Scholar
  196. Nichols, D. H., and Weston, J. A., 1977, Melanogenesis in cultures of peripheral nerve tissue. I. The origin and prospective fate of cells giving rise to melanocytes, Dev. Biol. 60:217.PubMedCrossRefGoogle Scholar
  197. Nichols, D. H., Kaplan, R. A., and Weston, J. A., 1977, Melanogenesis in cultures of peripheral nerve tissue. II. Environmental factors determining the fate of pigment-forming cells, Dev. Biol. 60:226.PubMedCrossRefGoogle Scholar
  198. Noden, D. M., 1975, An analysis of the migratory behavior of the avian cephalic neural crest cells, Dev. Biol. 42:106.PubMedCrossRefGoogle Scholar
  199. Noonan, K. D., 1978, Proteolytic modification of cell surface macromolecules: Mode of action in stimulating cell growth, in: Current Topics in Membranes and Transport: Cell Surface Glycoproteins, Vol. XI (R. L. Juliano and A. Rothstein, eds.), pp. 397–461, Academic Press, New York.Google Scholar
  200. Nornes, H. O., and Das, G. D., 1972, Temporal pattern of neurogenesis in spinal cord: Cytoarchitecture and directed growth of axons, Proc. Natl. Acad. Sci. U.S.A 69:1962.PubMedCrossRefGoogle Scholar
  201. Nowak, T. P., and Barondes, S. H., 1977, Lectin activity in embryonic chick muscle: Developmental regulation and preliminary purification, Prog. Clin. Biol. Res. 15:159.PubMedGoogle Scholar
  202. Nowak, T. P., Haywood, P. L., and Barondes, S. H., 1976, Developmentally regulated lectin in embryonic chick muscle and myogenic cell line, Biochem. Biophys. Res. Commun. 68:650.PubMedCrossRefGoogle Scholar
  203. Ofek, I., Beachey, E. H., Eyal, F., and Morrision, J. C., 1977, Postnatal development of binding of streptococci and lipoteichoic acid by oral mucosal cells of humans, J. Infect. Dis. 135:267.PubMedCrossRefGoogle Scholar
  204. Okazaki, K., and Holtzer, H., 1965, An analysis of myogenesis in vitro using fluorescin-labelled antimyosin, J. Histochem. Cytochem. 13:726.PubMedCrossRefGoogle Scholar
  205. Otsuka, H., and Moskowitz, M., 1976, Arrest of 3T3 cells in G1 phase in suspension culture, J. Cell. Physiol. 87:213.CrossRefGoogle Scholar
  206. Overton, J., 1977a, Formation of junctions and cell sorting in aggregates of chick and mouse cells, Dev. Biol. 55:103.PubMedCrossRefGoogle Scholar
  207. Overton, J., 1977b, Response of epithelial and mesenchymal cells to culture on basement lamella observed by scanning microscopy, Exp. Cell Res. 105:313.Google Scholar
  208. Pardee, A. B., 1975, The cell surface and fibroblast proliferation. Some current research trends, Biochim. Biophy. Acta 417:153.Google Scholar
  209. Parkinson, E. K., and Edwards, J. G., 1978, Non-reciprocal contact inhibition of locomotion of chick embryonic choroid fibroblasts by pigmented retina epithelial cells, J. Cell Sci. 33:103.PubMedGoogle Scholar
  210. Penman, S., 1979, Metabolic regulation is suspended and reattached anchorage-dependent fibroblasts, J. Supramnl. Struct. Subbl. 3:174.Google Scholar
  211. Pennypacker, J. P., Hassell, J. R., Yamada, K. M. and Pratt, R. M. 1978, The influence of fibronectin on chnndrngenic exnression in vitro. J. Cell Biol. 79:149a.Google Scholar
  212. Pfenninger, K. H., and Pfenninger, M. F., 1975, Distribution and fate of lectin binding sites on the surface of growing neuronal processes, J. Cell Biol. 67:332a.Google Scholar
  213. Pollack, R., and Rifkin, D., 1975, Actin-containing cables within anchorage-dependent rat embryo cells are dissociated by plasmin and trypsin, Cell 6:495.CrossRefGoogle Scholar
  214. Pollack, R., Osborn, M., and Weber, K., 1975, Patterns of organization of actin and myosin in normal and transfnrmed cultured cells. Proc. Natl. Acad. Sci. U.S.A 72:994.PubMedCrossRefGoogle Scholar
  215. Pouyssegur, J. M., and Pastan, I., 1976, Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: Evidence for alteration in cell surface protein, Proc. Natl. Acad. Sci. U.S.A 73:544.PubMedCrossRefGoogle Scholar
  216. Pratt, R. M., Larson, M. A., and Johnston, M. C., 1975, Migration of cranial neural crest cells in a cell-free hvaluronic acid rich matrix, Dev. Biol. 44:298.PubMedCrossRefGoogle Scholar
  217. Puck, T., 1977, Cyclic AMP, the microtubule-microfilament system, and cancer, Proc. Natl. Acad. Sci. U.S.A 74:4491.PubMedCrossRefGoogle Scholar
  218. Rajaraman, R., Rounds, D. E., Yen, S. P. S., and Rembaum, A., 1974, A scanning electron microscope study of cell adhesion and spreading in vitro, Exp. Cell Res. 88:327.PubMedCrossRefGoogle Scholar
  219. Rakic, P., 1971, Guidance of neurons migrating to the fetal monkey neocortex, Brain Res. 33:471.PubMedCrossRefGoogle Scholar
  220. Rees, D. A., Lloyd, C. W., and Thom, D., 1977, Control of grip and stick in cell adhesion through lateral relationships of membrane glycoproteins, Nature (London) 267:124.CrossRefGoogle Scholar
  221. Revel, J. P., and Wolken, K., 1973, Electron microscope investigations of the underside of cells in culture, Exp. Cell Res. 78:1.PubMedCrossRefGoogle Scholar
  222. Revel, J. P., Hoch, P., and Ho, D., 1974, Adhesion of cultured cells to their substratum, Exp. Cell Res. 84:207.PubMedCrossRefGoogle Scholar
  223. Risser, R., and Pollack, R., 1974, A nonselective analysis of SV40 transformation of mouse 3T3 cells, Virology 59:477.PubMedCrossRefGoogle Scholar
  224. Roblin, R., Albert, S. O., Gelb, N. A., and Black, P. H., 1975, Cell surface changes correlated with densitydependent growth inhibition. Glycosaminoglycan metabolism in 3T3, SV3T3, and Con A selected revertant cells, Biochemistry 14:347.PubMedCrossRefGoogle Scholar
  225. Roseman, S., 1974, Complex carbohydrates and intercellular adhesion, in: The Cell Surface in Development (A A. Moscona. ed.), pp. 255–271, Wiley, New York.Google Scholar
  226. Rosen, J. J., and Culp, L. A., 1977, Morphology and cellular origins of substrate-attached material from mouse fibroblasts, Exp. Cell Res. 107:139.PubMedCrossRefGoogle Scholar
  227. Roth, S., 1968, Studies on intercellular adhesive selectivity, Dev. Biol. 18:602.PubMedCrossRefGoogle Scholar
  228. Roth, S., 1973. A molecular model for cell interactions, Q. Rev. Biol. 48:541.PubMedCrossRefGoogle Scholar
  229. Rovensky, Y. A., and Slavnaja, I. L., 1974, Spreading of fibroblast-like cells on grooved surfaces, Exp. Cell Res. 84:199.PubMedCrossRefGoogle Scholar
  230. Rovensky, Y. A., Slavnaja, I. L., and Vasiliev, J. M., 1971, Behavior of fibroblast-like cells on grooved surfaces, Exo. Cell Res. 65:193.CrossRefGoogle Scholar
  231. Rubin, R. W., Warren, R. H., Lukeman, D. S., and Clements, E., 1978, Actin content and organization in normal and transformed cells in culture, J. Cell Biol. 78:28.PubMedCrossRefGoogle Scholar
  232. Ruoslahti, E., Hayman, E. G., and Engvall, E. 1979, Interaction of fibronectin with collagens, and its role in cell adhesion, J. Subramol. Struct. Suppl. 3:173 (abstract).Google Scholar
  233. Rutishauser, U., Thiery, J. P., Brackenbury, R., Sela, B. A., and Edelman, G. M., 1976, Mechanisms of adhesion among cells from neural tissues of the chick embryo, Proc. Natl. Acad. Sci. U.S.A 73:577.PubMedCrossRefGoogle Scholar
  234. Salzer, J., Glaser, L., and Bunge, R. P., 1977, Stimulation of Schwann cell proliferation by a neurite membrane fraction. J. Cell Biol. 75:118a (abstract).Google Scholar
  235. Sanger, J. W., and Holtzer, H., 1972, Cytochalasin B: Effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis, Proc. Natl. Acad. Sci. U.S.A 69:253.PubMedCrossRefGoogle Scholar
  236. Schubert, D., Lacorbine, M., and Watson, J., 1976, Growth regulation of cells grown in suspension culture, Nature (London) 264:266.CrossRefGoogle Scholar
  237. Santerre, R. F., and Rich, A., 1976, Actin accumulation in developing chick brain and other tissues, Dev. Biol. 54:1.PubMedCrossRefGoogle Scholar
  238. Schaeffer, B. E., Schaeffer, H. E., and Brick, I., 1973, Cell electrophoresis of amphibian blastula and gastrula cells: The relationship of surface charge and morphogenetic movement, Dev. Biol. 34:66.PubMedCrossRefGoogle Scholar
  239. Sengel, P., 1976, Morphogenesis of Skin, Cambridge University Press, Cambridge.Google Scholar
  240. Shadle, P. J., Kobiler, D., and Barondes, S. H., 1979, Lectin-2 from embryonic chick muscle interacts with glycosaminoglycans from extracellular matrix, J. Supramol. Struct. Suppl. 3:204.Google Scholar
  241. Shimada, Y., Fischman, D. A., and Moscona, A. A., 1969a, Formation of neuromuscular junctions in embryonic cell cultures, Proc. Natl. Acad. Sci. U.S.A. 62:715.PubMedCrossRefGoogle Scholar
  242. Shimada, Y., Fischman, D. A., Moscona, A. A., 1969b, The development of nerve-muscle junctions in monolayer cultures of embryonic spinal cord and skeletal muscle cells, J. Cell Biol. 43:382.PubMedCrossRefGoogle Scholar
  243. Shin, S. I., Freedman, V. H., Risser, R., and Pollack, R., 1975, Tumorigencity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro, Proc. Natl. Acad. Sci. U.S.A. 72:4435.PubMedCrossRefGoogle Scholar
  244. Shur, B. D., 1977, Cell-surface glycosyltransferases in gastrulating chick embryos, Dev. Biol. 58:23.PubMedCrossRefGoogle Scholar
  245. Shur, B., and Roth, S., 1973, The localization and potential function of glycosyltransferases in chick embryos, Am. Zool. 13:1129.Google Scholar
  246. Sidman, R. L., and Wessells, N. K., 1975, Control of direction of growth during the elongation of neurites, Exp. Neurol. 48:237.PubMedCrossRefGoogle Scholar
  247. Small, J. V., Isenberg, G., and Celis, J. E., 1978, Polarity of actin at the leading edge of cultured cells, Nature (London) 272:638.CrossRefGoogle Scholar
  248. Spooner, B. S., Yamada, K. M., and Wessells, N. K., 1971, Microfilaments and cell locomotion, J. Cell Biol. 49:593.CrossRefGoogle Scholar
  249. Stathakis, N. E., and Mossesson, M. W., 1977, Interactions among heparin, cold-insoluble globulin and fibronectin in formation of the heparin-precipitable fraction of serum, J. Clin. Invest. 60:855.PubMedCrossRefGoogle Scholar
  250. Steinberg, M. S., Armstrong, P. B., and Granger, R. E., 1973, On the recovery of adhesiveness by trypsindissociated cells, J. Membr. Biol. 13:97.PubMedCrossRefGoogle Scholar
  251. Stenman, S., Wartiovaara, J., and Vaheri, A., 1977, Changes in the distribution of a major fibroblast protein, fibronectin, during mitosis and interphase, J. Cell Biol. 74:453.PubMedCrossRefGoogle Scholar
  252. Stenn, K. S., Madri, J. A., and Roll, F. J., 1979, Migrating epidermis produces AB2 collagen and requires continual collagen synthesis for movement, Nature (London) 277:229.CrossRefGoogle Scholar
  253. Stoker, M., O’Neill, C., Berryman, S., and Waxman, V., 1968, Anchorage and growth regulation in normal and virus transformed cells, Int. J. Cancer 3:683.PubMedCrossRefGoogle Scholar
  254. Strassman, R. J., Letourneau, P. C., and Wessells, N. K., 1973, Elongation of axons in an agar matrix that does not support cell locomotion, Exp. Cell Res. 81:482.PubMedCrossRefGoogle Scholar
  255. Teichberg, V. I., Silman, I., Beitsch, D. D., and Resheff, G., 1975, A β-D-galactoside binding protein from electric organ tissue of Electrophorus electricus, Proc. Natl. Acad. Sci. U.S.A. 72:1383.PubMedCrossRefGoogle Scholar
  256. Teng, N. N. H., and Chen, L. B., 1975, The role of surface proteins in cell proliferation as studied with thrombin and other proteases, Proc. Natl. Acad. Sci. U.S.A. 72:413.PubMedCrossRefGoogle Scholar
  257. Tickle, C. A., and Trinkaus, J. P., 1973, Change in surface extensibility of Fundulus deep cells during early development, J. Cell Sci. 13:721.PubMedGoogle Scholar
  258. Toh, B. H., and Hard, G. C., 1977, Actin co-caps with concanavalin A receptors, Nature (London) 269:695.CrossRefGoogle Scholar
  259. Toole, B. P., and Trelstad, R. L., 1971, Hyaluronate production and removal during corneal development in the chick, Dev. Biol. 26:28.PubMedCrossRefGoogle Scholar
  260. Toole, B. P., Jackson, G., and Gross, J., 1972, Hyaluronate in morphogenesis: Inhibition of chondrogenesis in vitro, Proc. Natl. Acad. Sci. U.S.A. 69:1384.PubMedCrossRefGoogle Scholar
  261. Trelstad, R. L., Hayashi, K., and Toole, B. P., 1974, Epithelial collagens and glycosaminoglycans in the embryonic cornea. Macromolecular order and morphogenesis in the basement membrane, J. Cell Biol. 62:815.PubMedCrossRefGoogle Scholar
  262. Trinkaus, J. P., 1969, Cells into Organs. The Forces That Shape the Embryo, Prentice-Hall, Englewood Cliffs, N. J.Google Scholar
  263. Trinkaus, J. P., 1973, Surface activity and locomotion of Fundulus deep cells during blastula and gastrula stages, Dev. Biol. 30:68.CrossRefGoogle Scholar
  264. Trinkaus, J. P., 1976, On the mechanism of metazoan cell movements, in: The Cell Surface in Animal Embryogenesis and Development (G. Poste and G. L. Nicolson, eds.), pp. 225–329, North-Holland, Amsterdam.Google Scholar
  265. Trinkaus, J. P., Betchaky, T., and Krulikowski, L. S., 1971, Local inhibition of ruffling during contact inhibition of cell movement, Exp. Cell Res. 64:291.PubMedCrossRefGoogle Scholar
  266. Turner, R. S., and Burger, M. M., 1973, Involvement of a carbohydrate group in the active site for surface guided reassociation of animal cells, Nature (London) 244:509.CrossRefGoogle Scholar
  267. Ukena, T. E., and Karnovsky, M. J., 1977, The role of microvilli in the agglutination of cells by concanavalin A, Exp . Cell Res. 106:309.PubMedCrossRefGoogle Scholar
  268. Umbreit, J., and Roseman, S., 1975, A requirement for reversible binding between aggregating embryonic cells before stable adhesion, J. Cell Biol. 250:9360.Google Scholar
  269. Vaheri, A., Kurkinen, M., Lehto, V. P., Linder, E., and Timpl, R., 1978, Codistribution of pericellular matrix proteins in cultured fibroblasts and loss in transformation: Fibronectin and collagen, Proc. Natl. Acad. Sci. UIS.A 75:4944.CrossRefGoogle Scholar
  270. Vasiliev, J. M., Gelfand, I. M., Domnina, L. V., Ivanova, O. Y., Komm, S. G., and Olshevskaja, L. V., 1970, Effect of colcemid on the locomotory behavior of fibroblasts, J. Embryol. Exp. Morphol. 24:625.PubMedGoogle Scholar
  271. Vasiliev, J. M., Gelfand, I. M., Domnina, L. V., Zacharova, O. S., and Ljubimov, A. V., 1975, Contact inhibition of phagocytosis in epithelial sheets: Alterations of cell surface properties induced by cell-cell contact, Proc. Natl. Acad. Sci. U.S.A 72:719.PubMedCrossRefGoogle Scholar
  272. Vasiliev, J. M., Gelfand, I. M., Domnina, L. V., Dorfman, N. A., and Pletjushkina, O. J., 1976, Active cell edge and movements of concanavalin A receptors of the surface of epithelial and fibroblastic cells, Proc. Natl. Acad. Sci. U.S.A 73:4085.PubMedCrossRefGoogle Scholar
  273. Weiss, L., 1977, Some biophysical aspects of cell contact, detachment and movement, in: Cell Interactions in Differentiation (M. Kartinen-Jaaskelainen, L. Saxen, and L. Weiss, eds.), pp. 279–289, Academic Press, New York.Google Scholar
  274. Weiss, L. and Greep, R. O., 1977, Histology, McGraw-Hill, New York.Google Scholar
  275. Weiss, P., 1941, Nerve patterns: The mechanics of nerve growth, Growth (Suppl.) 5:163.Google Scholar
  276. Weiss, P., 1945, Experiments on cell and axon orientation in vitro: The role of colloidal exudates in tissue organization, J. Exp. Zool. 100:353.PubMedCrossRefGoogle Scholar
  277. Wessells, N. K., Letourneau, P. C., Nuttall, R. P., Luduena-Anderson, M. A., and Geiduschek, J. M., 1980, Reciprocal absence of contact paralysis when motile growth cones and glial cells meet, J. Neurocytol., in press.Google Scholar
  278. Whittenberger, B., and Glaser, L., 1977, Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes, Proc. Natl. Acad. Sci. U.S.A 74:2251.PubMedCrossRefGoogle Scholar
  279. Wiese, L., and Wiese, W., 1975, On sexual agglutination and mating type substances in isogamous ioecious Chlamydomonads, Dev. Biol. 43:264.PubMedCrossRefGoogle Scholar
  280. Wilde, C. E., Jr., 1958, The fusion of myoblasts, a morphogenetic mechanism in striated muscle differentiation, Anat. Rec. 132:517.Google Scholar
  281. Wilde, C. E., Jr., 1959, Differentiation in response to the biochemical environment, in: Cell, Organism and Milieu (D. Rudnick, ed.), Ronald Press, New York.Google Scholar
  282. Willingham, M. C., Yamada, K. M., Yamada, S. S., Pouyssegur, J., and Pastan, I., 1977, Microfilament bundles, and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts, Cell 10:375.PubMedCrossRefGoogle Scholar
  283. Wood, P. M., 1976, Separation of functional Schwann cells and neurons from normal peripheral nerve tissue, Brain Res. 115:361.PubMedCrossRefGoogle Scholar
  284. Yaffe, D., 1969, Cellular aspects of muscle differentiation in vitro, Curr. Top. Dev. Biol. 4:37.PubMedCrossRefGoogle Scholar
  285. Yaffe, D., 1971, Developmental changes preceding cell fusion during muscle differentiation in vitro, Exp. Cell Res. 66:33.PubMedCrossRefGoogle Scholar
  286. Yaffe, D., and Feldman, M., 1965, The formation of multinucleated muscle fibers from myoblasts of different genetic origins. Dev. Biol. 11:300.PubMedCrossRefGoogle Scholar
  287. Yamada, K., 1978, Immunological characterization of a major transformation-sensitive fibroblast cell surface gl vconrotein. J. Cell Biol. 78:520.PubMedCrossRefGoogle Scholar
  288. Yamada, K. M., and Kennedy, D. W., 1979, Fibroblast cellular and plasma fibronectins are similar but not identical. J. Cell Biol. 80:492.PubMedCrossRefGoogle Scholar
  289. Yamada, K. M., and Olden, K., 1978, Fibronectins: Adhesive glycoproteins of cell surface and blood, Nature (London) 275:179.CrossRefGoogle Scholar
  290. Yamada, K. M., and Pastan, I., 1976, Cell surface protein and neoplastic transformation, Trends Biochem. Sci. 1:222.Google Scholar
  291. Yamada, K. M., Spooner, B. S., and Wessells, N. K., 1971, Ultrastructure and function of growth cones and axons of cultured nerve cells, J. Cell Biol. 49:614.PubMedCrossRefGoogle Scholar
  292. Yamada, K. M., Yamada, S. S., and Pastan, I., 1976, Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed cells, Proc. Natl. Acad. Sci. U.S.A. 73:1217.PubMedCrossRefGoogle Scholar
  293. Yamada, K. M., Olden, K., and Pastan, I., 1978, Transformation sensitive cell surface protein: Isolation, characterization, and role in cellular morphology and adhesion, Ann. N.Y. Acad. Sci. 312:256.PubMedCrossRefGoogle Scholar
  294. Yamada, K. M., Hahn, L. E., and Olden, K., 1979, Structure and function of the fibronectins, J. Supramol. Struct. Suppl. 3:187 (abstract).Google Scholar
  295. Zetter, B. R., Chen, L. B., and Buchanan, J. M., 1976, Effects of protease treatment on growth, morphology, adhesion, and cell surface proteins of secondary chick embryo fibroblasts, Cell 7:407.PubMedCrossRefGoogle Scholar
  296. Zetter, B. R., Johnson, L. K., Shuman, M. A., and Gospodarowicz, D., 1978, The isolation of vascular endothelial cell lines with altered cell surface and platelet-binding properties, Cell 14:501.PubMedCrossRefGoogle Scholar
  297. Zucco, F., Persico, M., Felsani, A., Metafora, O. S., and Augusti-Tocco, G., 1975, Regulation of protein synthesis at the translational level in neuroblastoma cells, Proc. Natl. Acad. Sci. U.S.A 72:2289.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Paul C. Letourneau
    • 1
  • Peter N. Ray
    • 2
  • Merton R. Bernfield
    • 3
  1. 1.Department of AnatomyUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of Medical GeneticsUniversity of TorontoTorontoCanada
  3. 3.Department of PediatricsStanford University School of MedicineStanfordUSA

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