Vitamin B-6 and Sulfur Amino Acid Metabolism

  • John A. Sturman


Vitamin B-6, in the form of pyridoxal 5- phosphate, is the coenzyme required by many of the enzymes involved in the metabolism of sulfur-containing amino acids (Fig. 1). Methionine, cyst(e)ine, and taurine, of the chemicals listed in this scheme, are generally available in the diet. Methionine is an essential amino acid for mammals, although the requirement can be spared to some extent by cystine. Cyst(e)ine is not generally an essential amino acid for mammals, since adequate amounts may be produced from methionine via the transsulfuration pathway, although it may be essential for a period after birth in some species as a result of the postnatal development of cystathionase. Taurine is an aminosulfonic acid whose role in development and nutrition has been the subject of much recent research and debate. It is an essential nutrient for the cat and kitten, and may be for some primates, including man.


Culture Skin Fibroblast Responsive Patient Lymphoid Cell Line Transsulfuration Pathway Pyridoxine Hydrochloride 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • John A. Sturman
    • 1
  1. 1.Developmental Neurochemistry Laboratory, Department of Pathological NeurobiologyInstitute for Basic Research in Mental RetardationStaten IslandUSA

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