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Plasma PLP as Indicator of Nutrition Status: Relationship to Tissue Vitamin B-6 Content and Hepatic Metabolism

  • Ting-Kai Li
  • Lawrence Lumeng

Abstract

In assessment of nutritional status, diagnostic indicators should correlate in a well-defined manner not only with tissue content but also with the functional adequacy of the substance in question. Ideally, they would measure undernutrition as well as storage capacity. It is fortunate in the instance of vitamin B-6 that both the storage and the coenzyme (functional) forms are the same compounds, viz., the phosphorylated derivatives, pyridoxal phosphate (PLP) and pyridoxamine phosphate (PMP). These coenzyme forms are interconvertible via transamination reactions, but different tissues and body fluid compartments contain different amounts and ratios of PLP and PMP, presumedly reflecting regional peculiarities and dependence for the function of certain PLP-specific enzymes and binding proteins. Accordingly, if plasma PLP concentration is to serve as a diagnostic indicator, its relationship to the PLP (and PMP) content of tissues and to the activities of representative PLP-dependent enzymes must be delineated under conditions of both vitamin B-6 deficiency and excess. Furthermore, because the liver is the principal, if not the sole, organ that supplies blood plasma with PLP (1), the dependence of PLP and other B-6 vitamers in plasma upon hepatic metabolism needs to be understood. This communication summarizes recent studies from our laboratory and those of others that address these issues.

Keywords

Celiac Disease Glycogen Phosphorylase Human Blood Plasma Pyridoxal Phosphate Pyridoxine Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Ting-Kai Li
    • 1
  • Lawrence Lumeng
    • 1
  1. 1.VA Medical Center & Departments of Medicine and BiochemistryIndiana University School of MedicineIndianapolisUSA

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