Vitamin B-6 Status Assessment: Past and Present

  • H. E. Sauberlich


In 1934, György established the existence of vitamin B-6 (1,2). Followijg the synthesis of vitamin B-6 in 1939 by Harris and Folkers (3), Gyorgy suggested that “In accordance with the chemical nature of vitamin B-6, which is a pyridine derivative containing several methoxyl groups, the term ‘pyridoxine’ appears appropriate” (4). György recognized that vitamin B-6 deficiency in the rat produced lesions of the extremities that resembled those observed in human acrodynia rather than of pellagra.


Quinolinic Acid Pyridoxal Phosphate Convulsive Seizure Seborrheic Dermatitis Xanthurenic Acid 
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Literature Cited

  1. 1.
    György, P. (1934) Vitamin B-2 and the pellagra-like dermatitis in rats. Nature 133, 498-499.CrossRefGoogle Scholar
  2. 2.
    György, P. (1935) Vitamin B-2 complex. I. Differentiation of lactoflavin and the “rat antipellagra” factor. Biochem. J. 29, 741-759.Google Scholar
  3. 3.
    Harris, S. A., Folkers, K. (1939) Synthetic vitamin B-6. Science 89, 347.CrossRefGoogle Scholar
  4. 4.
    György, P., Eckhardt, R. E. (1939) Vitamin B-6 and skin lesions in rats. Nature 144, 512.CrossRefGoogle Scholar
  5. 5.
    Spies, T. D., Bean, W. B., Ashe, W. F. (1939) A note on the use of vitamin B-6 in human nutrition. J. Am. Med. Assoc. 112, 2414-2415.CrossRefGoogle Scholar
  6. 6.
    Spies, T. D., Ladisch, R. K. , Bean, W. B. (1940) Vitamin B-6 (pyridoxine) deficiency in human beings. J. Am. Med. Assoc. 115, 839-840.CrossRefGoogle Scholar
  7. 7.
    Smith, S. G. , Martin, D. W. (1940) Cheilosis successfully treated with synthetic vitamin B-6. Proc. Soc. Expt. Biol. Med. 43, 660-663.Google Scholar
  8. 8.
    Molony, C. J. , Parmelee, A. H. (1954) Convulsions in young infants as a result of pyridoxine (vitamin B-6) deficiency. J. Am. Med. Assoc. 154, 405-406.CrossRefGoogle Scholar
  9. 9.
    Coursin, D. B. 19-5TY Convulsive seizures in infants with pyridoxine-deficient diet. J. Am. Med. Assoc. 154, 406-407.Google Scholar
  10. 10.
    Sauberlich, H. E. , Canham, J. E. (1980) Vitamin B-6. In: Modern Nutrition in Health and Disease (Goodhart, R. S. , Shils, M. E., eds.), 6th ed., pp. 216-229. Lea , Febiger, Philadelphia, PA.Google Scholar
  11. 11.
    Bessey, O. A., Adam, D. J. D. , Hansen, A. E. (1957) Intake of vitamin B-6 and infantile convulsions: A first approximation of requirements of pyridoxine in infants. Pediatrics 20, 33-44.Google Scholar
  12. 12.
    Hunt, A. D., Jr., Stokes, J., Jr., McCrory, W. W. , Stroud, H. H. (1954) Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine. Pediatrics 13, 140-146.Google Scholar
  13. 13.
    Waldinger, C. , Berg, R. B. (1963) Signs of pyridoxine dependency manifest at birth in siblings. Pediatrics 32, 161-168.Google Scholar
  14. 14.
    Harris, J. W., Whittington, R. M., Weisman, R., Jr., , Horrigan, D. L. (1956) Pyridoxine responsive anemia in the human adult. Proc. Soc. Expt. Biol. Med. 91, 427-432.Google Scholar
  15. 15.
    Hines, J. D. , Harris, J. W. (1964) Pyridoxine-responsive anemia. Am. J. Clin. Nutr. 14, 137-146.Google Scholar
  16. 16.
    Mudd, S. H. (1971) Pyridoxine-responsive genetic disease. Fed. Proc. 30, 970-976.Google Scholar
  17. 17.
    Frimpter, G. W., Andelman, R. J. , George, W. F. (1969) Vitamin B-6-dependency syndromes. Am. J. Clin. Nutr. 22, 794-805.Google Scholar
  18. 18.
    Knapp, A. (1960) Uber eine neue hereditare von vitamin B-6 abhangige storung im tryptophan-stoffwechsel. Clin. Chim. Acta 5, 6-13.Google Scholar
  19. 19.
    Spannúth, C. L., Mitchell, D., Stone, W. J., Schenker, S. , Wagner, C. (1978) Vitamin B-6 nutriture in patients with uremia and with liver disease. In: Human Vitamin B-6 Requirements, pp. 180-192, Nat. Acad. Sci., Washington, DC.Google Scholar
  20. 20.
    Walsh, M. P., Howorth, P. J. N. , Marks, V. (1966) Pyridoxine deficiency and tryptophan metabolism in chronic alcoholics. Am. J. Clin. Nutr. 19, 379-383.Google Scholar
  21. 21.
    Li, T.-K. (1978) Factors influencing vitamin B-6 requirement in alcoholism. In: Human Vitamin B-6 Requirements, pp. 210-225, Nat. Acad. Sci., Washington, DC.Google Scholar
  22. 22.
    Rose, D. P. (1966) The influence of oestrogens upon tryptophan metabolism in man. Clin. Sci. 31, 265-272.Google Scholar
  23. 23.
    Rose, D. P. (1978) Oral contraceptives and vitamin B-6. In: Human Vitamin B-6 Requirements, pp. 193-201, Nat. Acad. Sci., Washington, DC.Google Scholar
  24. 24.
    Krishnaswany, K. (1971) Erythrocyte glutamic oxaloacetic transaminase activity in patients with oral lesions. Internat. J. Vit. Nutr. Res. 41, 247-252.Google Scholar
  25. 25.
    Krishnaswany, K. (1971) Erythrocyte transaminase activity in human vitamin B-6 deficiency. Internat. J. Vit. Nutr. Res. 41, 240-246.Google Scholar
  26. 26.
    Krishnaswany, K., Bapurao, S., Raghuram, T. C. , Srikantia, S. G. (1976) Effect of vitamin B-6 on leucine-induced changes in human subjects. Am. J. Clin. Nutr. 29, 177-181.Google Scholar
  27. 27.
    Bapurao, S. , Krishanswany, K. (1978) Vitamin B-6 nutritional status of pellagrins and their leucine tolerance. Am. J. Clin. Nutr. 31, 819-824.Google Scholar
  28. 28.
    Bamji, M. S., Rameshwar Sarma, K. V. , Radhaiah, G. (1979) Relationship between biochemical and clinical indices of B-vitamin deficiency. A study in rural school boys. Br. J. Nutr. 41, 431-441.CrossRefGoogle Scholar
  29. 29.
    Wachstein, M., Kellner, J. D. , Ortiz, J. M. (1960) Pyridoxal phosphate in plasma and leukocytes of normal and pregnant subjects following B-6 load tests. Proc. Soc. Expt. Biol. Med. 103, 350-353.Google Scholar
  30. 30.
    Dempsey, W. B. (1978) Vitamin B-6 and pregnancy. In: Human Vitamin B-6 Requirements, pp. 202-209, Nat. Acad. Sci., Washington, DC.Google Scholar
  31. 31.
    Sauberlich, H. E. (1978) Vitamin indices. In: Laboratory Indices of Nutritional Status in Pregnancy, pp. 109-156, Nat. Acad. Sci., Washington, DC.Google Scholar
  32. 32.
    Lepkovsky, S., Roboz, E. , Hargen-Smith, A. J. (1943) Xanthurenic acid and its role in the tryptophan metabolism of pyridoxine-deficient rats. J. Biol. Chem. 149, 195-201.Google Scholar
  33. 33.
    Greenberg, L. D., Bohr, D. F., McGrath, H. , Rinehart, J. F. (1949) Xanthurenic acid excretion in the human subject on pyridoxine-deficient diet. Arch. Biochem. 21, 237-239.Google Scholar
  34. 34.
    Snyderman, S. E., Holt, L. E., Jr., Carretero, R. , Jacobs, K. (1953) Pyridoxine deficiency in human infant. J. Clin. Nutr. 1, 200-207.Google Scholar
  35. 35.
    Mueller, J. F. , Vilter, R. W. (1950) Pyridoxine deficiency in human beings induced with deoxypyridoxine. J. Clin. Invest. 29, 193-201.CrossRefGoogle Scholar
  36. 36.
    Vilter, R. W., Mueller, J. F., Glazer, H. S., Jarrold, T., Abraham, J., Thompson, C. , Hawkins, V. R. (1953) The effect of vitamin B-6 deficiency induced by deoxypyridoxine in human beings. J. Lab. Clin. Med. 42, 335-357.Google Scholar
  37. 37.
    Harding, R. S., Plough, I.C., Friedemann, T. E. (1959) The effect of storage on the vitamin B-6 content of a packaged Army ration, with a note on the human requirement for the vitamin. J. Nutr. 68, 323-332.Google Scholar
  38. 38.
    Cheslock, K. E. , McCully, M. T. (1960) Response of human beings to a low-vitamin B-6 diet. J. Nutr. 70, 507-513.Google Scholar
  39. 39.
    Babcock, M. J., Brush, M. , Sostman, E. (1960) Evaluation of vitamin B-6 nutrition. J. Nutr. 70, 369-376.Google Scholar
  40. 40.
    Hodges, R. E., Bean, W. B., Ohlson, M. A. , Bleiler, R. E. (1962) Factors affecting human antibody response. IV. Pyridoxine deficiency. Am. J. Clin. Nutr. 11, 180-186.Google Scholar
  41. 41.
    Sauberlich, H. E., Canham, J. R., Baker, E. M., Raica, N., Jr. , Herman, Y. F. (1970) Human vitamin B-6 nutriture. J. Sci. , Ind. Res. 29, 1-10.Google Scholar
  42. 42.
    Sauberlich, H. E. (1964) Human requirements for vitamin B-6. Vit. Hormones 22, 807-823.Google Scholar
  43. 43.
    Baker, E. M., Canham, J. E., Nunes, W. T., Sauberlich, H. E. , McDowell, M. E. (1964) Vitamin B-6 requirement for adult men. Am. J. Clin. Nutr. 15, 59-66.Google Scholar
  44. 44.
    Raica, N., Jr. , Sauberlich, H. E. (1964) Blood cell trans- aminase activity in human vitamin B-6 deficiency. Am. J. Clin. Nutr. 15, 67-72.Google Scholar
  45. 45.
    Sauberlich, H. E., Dowdy, R. P. , Skala, J. H. (1974) Labo- ratory tests for the assessment of nutritional status. CRC Press, Inc., Boca Raton, Florida.Google Scholar
  46. 46.
    Sauberlich, H. E., Canham, J. E., Baker, E. M., Raica, N. Jr. , Herman, Y. F. (1972) Biochemical assessment of the nutritional status of vitamin B-6 in the human. Am. J. Clin. Nutr. 25, 629-642.Google Scholar
  47. 47.
    Yess, N., Price, J. M., Brown, R. R., Swan, P. B. , Linkswiler, H. (1964) Vitamin B-6 depletion in man: urinary excretion of tryptophan metabolites. J. Nutr. 84, 229-236.Google Scholar
  48. 48.
    Linkswiler, H. M. (1978) Vitamin B-6 requirements of men. In: Human Vitamin B-6 Requirements, pp. 279-290, Nat. Acad. Sci., Washington, DC.Google Scholar
  49. 49.
    Brown, R. R., Yess, N., Price, J. M., Linkswiler, H., Swan, P. , Hankes, L. V. (1965) Vitamin B-6 depletion in man: Urinary excretion of quinolinic acid and niacin metabolites. J. Nutr. 87, 419-423.Google Scholar
  50. 50.
    Kelsay, J., Miller, L. T. , Linkswiler, H. (1968) Effect of protein intake on the excretion of quinolinic acid and niacin metabolites by men during vitamin B-6 depletion. J. Nutr. 94, 27-31.Google Scholar
  51. 51.
    Kelsay, J., Baysal, A. , Linkswiler, H. (1968) Effect of vitamin B-6 depletion on the pyridoxal, pyridoxamine, and pyridoxine content of the blood and urine of men. J. Nutr. 94, 490-496.Google Scholar
  52. 52.
    Baysal, A., Johnson, B. A. , Linkswiler, H. (1966) Vitamin B-6 depletion in man: blood vitamin B-6, plasma pyridoxalphosphate, serum cholesterol, serum transaminases and urinary vitamin B-6 and 4-pyridoxic acid. J. Nutr. 89, 19-23.Google Scholar
  53. 53.
    Park, Y. K. , Linkswiler, H. (1970) Effect of vitamin B-6 depletion in adult man on the excretion of cystathionine and other metabolites. J. Nutr. 100, 110-116.Google Scholar
  54. 54.
    Shin, H. K. , Linkswiler, H. 1974 Tryptophan and methionine metabolism of adult females as affected by vitamin B-6 deficiency. J. Nutr. 104, 1348-1355.Google Scholar
  55. 55.
    Leklem, J. E., Brown, R. R., Rose, D. P. , Linkswiler, H. M. (1975) Vitamin B-6 requirements of women using oral contraceptives. Am. J. Clin. Nutr. 28, 535-541.Google Scholar
  56. 56.
    Donald, E. A., McBean, L. D., Simpson. M. H. W., Sun, M. F. , Aly, H. E. (1971) Vitamin B-6 requirement of young adult women. Am. J. Clin. Nutr. 24, 1028-1041.Google Scholar
  57. 57.
    Ritchey, S. J., Johnson, F. S. , Korslund, M. K. (1978) Vitamin B-6 requirements in the preadolescent and adolescent. In: Human Vitamin B-6 Requirements, pp. 272-278, Nat. Acad. Sci., Washington, DC.Google Scholar
  58. 58.
    Sauberlich, H. E., Goad, W., Herman, Y. F., Milan, F. , Jamison, P. (1972) Biochemical assessment of the nutritional status of the Eskimos of Wainwright, Alaska. Am. J. Clin. Nutr. 25, 437-445.Google Scholar
  59. 59.
    Marston, R. M. , Peterkin, B. B. Nutrient content of the national food supply. National Food Review, u.S. Dept. of Agriculture, Economics, Statistics, and Cooperative Serv., Winter 1980, NFR-9, 21.-25.Google Scholar
  60. 60.
    USDA Nationwide Food Consumption Survey, 48 States, Spring 1977 (preliminary). U.S. Dept. of Agriculture.Google Scholar
  61. 61.
    Canham, J. E., Baker, E. M., Harding, R. S., Sauberlich, H. E. , Plough, I. C. (1969) Dietary protein - its relationship to vitamin B-6 requirements and functions. Ann. N.Y. Acad. Sci. 166, 16-29.CrossRefGoogle Scholar
  62. 62.
    Howe, J., Wyse, B. W. , Hansen, R. G. (1979) Measurement of pantothenic acid in nursing home meals using a microbiological assay and a radioimmunoassay. Fed. Proc. 38, 452.Google Scholar
  63. 63.
    Wyse, B. W., Wittwer, C. W. , Hansen, R. G (1979) Radio- immunoassay for pantothenic acid in blood and other tissues. Clin. Chem. 25, 108-111.Google Scholar
  64. 64.
    Sauberlich, H. E. (1968) Vitamin B-6 group. VIII. Active compounds and antagonists. In: The Vitamins, vol. 2, 2nd ed. (Sebulla, W. H., Jr. , Harris, R. S., eds.), pp. 33-44, Academic Press, New York.Google Scholar
  65. 65.
    Lakshmi, A. V. , Bamji, M. S. (1974) Regulation of blood pyridoxal phosphate in riboflavin deficiency in man. Nutr. Metab. 20, 228-233.Google Scholar
  66. 66.
    Tillotson, J. A., Sauberlich, H. E., Baker, E. M. , Canham, J. E. (1966) Use of carbon-14 labeled vitamins in human nutrition studies: pyridoxine. Proc. of the Seventh Intern. Congr. of Nutr. (Hamburg) 5, 554-557.Google Scholar
  67. 67.
    Swan, P., Wentworth, J. , Linkswiler, H. (1964) Vitamin B-6 depletion in man: urinary taurine and sulfate excretion and nitrogen balance. J. Nutr. 84, 220-228.Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • H. E. Sauberlich
    • 1
  1. 1.Letterman Army Institute of Research and USDA-SEA Western Nutrition Research CenterPresidio of San FranciscoUSA

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