Mycoplasma-Cell Culture-Virus Interactions: A Brief Review

  • Michael F. Barile
  • Marion W. Grabowski
Part of the Cellular Senescence and Somatic Cell Genetics book series (CSSCG, volume 3)


It has been established that certain mycoplasmas can alter the activity and function of contaminated cell cultures and thereby markedly affect the results of study. Some of these effects have been reviewed elsewhere (1, 2). This presentation will briefly discuss three general aspects of mycoplasma-cell-virus interaction including: a) the cytopathic effects (CPE) produced by the myco-plasma fermenters; b) the inhibitory effect produced by the arginine utilizing mycoplasmas on lymphocyte blastformation; and c) the effects of mycoplasmas on virus propagation.


Cytopathic Effect Mycoplasma Pneumoniae Virus Yield Mycoplasma Contamination Cold Agglutinin 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Michael F. Barile
    • 1
  • Marion W. Grabowski
    • 1
  1. 1.Bureau of BiologicsFDABethesdaUSA

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