Genetic Effects of Mycoplasma
In this paper I'll summarize the effects and the apparent effects of mycoplasma on chromosomes and genes. The best known genetic effects of mycoplasma are on chromosomes. This was first reported by Fogh and Fogh in 1965 (1). In this report chromosomes of the FL/amnion line had been followed for 9 years without appreciable change in number. When the cells were infected with mycoplasma there was a reduction in chromosome number and a rise in chromosome aberrations. The chromosome number gradually decreased from a range of 70–76 to 63–68. Chromosome aberrations included open breaks and stable and unstable rearrangements. These started during the first days after infection and developed slowly in mycoplasma-infected cultures. In subsequent work (2,3) it was demonstrated that after elimination of mycoplasma by aureomycin treatment the reduced chromosome number and stable rearrangements persisted, but unstable aberrations were reduced to pre-infection levels.
KeywordsChromosome Aberration Chromosome Breakage Human Diploid Cell Hypoxanthine Phosphoribosyl Transferase Amniotic Fluid Cell
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