Control of Translation Initiation by Phosphorylation

  • John W. B. Hershey
Conference paper
Part of the Serono Symposia, USA book series (SERONOSYMP)


Translational control is defined as the efficiency whereby mRNAs are translated. We distinguish two major types of control mechanisms: (i) cis-acting elements in an mRNA that determine its intrinsic “strength” or efficiency—features that remain constant over time—and (ii) the effectiveness of the translational machinery to translate the mRNA—a condition that may be temporally modulated. Furthermore, we can focus on translational control either of a single species of mRNA (specific control) or of all mRNAs (global control).


Translation Initiation Initiation Factor Initiator Codon Translational Control Eukaryotic Initiation Factor 
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© Springer-Verlag New York, Inc. 1993

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  • John W. B. Hershey

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