Attachment Control of Fibroblast Proliferation

  • Richard K. Assoian
  • Thomas M. Guadagno
  • Stephen L. Dalton
Part of the Serono Symposia, USA book series (SERONOSYMP)


Growth factors, nutrients, and attachment are the three physiologic mediators of fibroblast cell division (1–4). Proliferating fibroblasts use growth factors to maintain cell cycle progression throughout most of Gl (4, 5). Fibroblasts leave the cell cycle and enter a quiescent, G0 state when growth factors are removed from nutrient-containing medium (4, 6). Reentry into the cell cycle requires stimulation of the G0/G1 transition, and these events are also growth factor mediated (4). Fewer studies have addressed the role of nutrients in fibroblast proliferation, but it is clear that nutrient depletion arrests fibroblast cell cycle progression in early G1 and prevents Gl-associated increases in cell size (3, 6).


Thymidine Incorporation Fibroblast Proliferation Integrin Subunit Nonadherent Cell Anchorage Independence 
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Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Richard K. Assoian
  • Thomas M. Guadagno
  • Stephen L. Dalton

There are no affiliations available

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