Cis-Acting Elements That Regulate Immunoglobulin Gene Transcription

  • Keats A. Nelms
Conference paper
Part of the Serono Symposia, USA book series (SERONOSYMP)


The mammalian immune system is composed of a complex mixture of organs, cells, and proteins. Perhaps the primary tool of the immune system is the immunoglobulin (Ig), produced by the B-lymphocyte. The function of Ig molecules is unique in that they specifically bind to foreign substances (antigens) and target these antigens for neutralization and processing by the immune system. Ig molecules have the general structure of 4 polypeptide chains, 2 identical heavy chains (HC) and 2 identical light chains (LC), linked covalently by HC-HC and LC-HC disulfide bonds. Antigen binding pockets are formed at the N-terminal regions of the HC-LC intermolecular junctions. The N-terminal regions of the HC and LC polypeptides, termed variable (V) regions, are relatively unique to each HC and LC polypeptide and are composed of conserved framework protein sequences as well as unique hypervariable sequences.


Enhancer Element Enhancer Function Intron Enhancer Octamer Motif Light Chain Polypeptide 
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  • Keats A. Nelms

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