Sorting of Membrane Proteins in the Endocytic and Exocytic Pathways

  • Michael G. Roth
  • Yoav I. Henis
  • Colleen B. Brewer
  • Nicholas T. Ktistakis
  • Shang-Pwu Shia
  • Janette Lazarovits
  • Ella Fire
  • D’Nette Thomas
  • David E. Zwart
Conference paper
Part of the Serono Symposia, USA book series (SERONOSYMP)


Cells maintain a complex traffic of membrane moving between secretory and endocytic organelles that have distinct protein compositions. This traffic requires mechanisms of sorting proteins into membrane domains that travel to specific destinations, and in the case of mobile proteins such as cell-surface receptors, multiple sorting events are required as the proteins circulate through various organelles. Considerable effort has been directed towards identifying the molecular interactions responsible for sorting membrane proteins (1–3), but our knowledge of the process is still limited.


Cytoplasmic Domain MDCK Cell Transferrin Receptor Basolateral Surface External Domain 
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Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Michael G. Roth
  • Yoav I. Henis
  • Colleen B. Brewer
  • Nicholas T. Ktistakis
  • Shang-Pwu Shia
  • Janette Lazarovits
  • Ella Fire
  • D’Nette Thomas
  • David E. Zwart

There are no affiliations available

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