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Protein Folding in the Endoplasmic Reticulum

  • Ari Helenius
  • Utpal Tatu
  • Thorsten Marquardt
  • Ineke Braakman
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

The endoplasmic reticulum (ER) is the first and usually the largest compartment of the secretory pathway. It is a highly specialized organelle primarily devoted to biosynthetic functions. In addition to lipid synthesis, it is responsible for protein translation, translocation, folding, assembly, and covalent modifications. The majority of the proteins made are for secretion into the extracellular space, for export to the plasma membrane, or for membranes and internal compartments that constitute the vacuolar system. Thus, the ER is responsible for generating an extensive palette of important receptors, hormones, enzymes, antibodies, inhibitors, extra-cellular matrix components, and the like. Most of these proteins are glycoproteins, many are oligomeric in their final mature form, and a majority contain intra- and/or interchain disulfide bonds.

Keywords

Endoplasmic Reticulum Disulfide Bond Protein Disulfide Isomerase Vesicular Stomatitis Virus Disulfide Bond Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Ari Helenius
  • Utpal Tatu
  • Thorsten Marquardt
  • Ineke Braakman

There are no affiliations available

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