Possible Role of Selective Gap Junctional Intercellular Communication in Multistage Carcinogenesis

  • Hiroshi Yamasaki
  • D. James Fitzgerald


Carcinogenesis modelling must incorporate current knowledge of the interaction between “initiated” preneoplastic cells and surrounding normal cells. In this context, an important mode of cell:cell interaction is that of gap-junctional intercellular communication (GJIC); in normal tissue, GJIC plays a key role in maintaining homeostasis, so it is therefore not surprising to find GJIC disturbance in cancer cells. Furthermore, since many tumour promoters can inhibit GJIC, it is possible that such inhibition is critical to the process of carcinogenesis. Advancing our understanding of GJIC disruption and how to reverse it should be useful in application to anti-carcinogenesis and tumour suppression.


Phorbol Ester Intercellular Communication Cellular Oncogene Multistage Carcinogenesis Mouse Epidermal Cell 
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© Birkhäuser Boston 1924

Authors and Affiliations

  • Hiroshi Yamasaki
  • D. James Fitzgerald

There are no affiliations available

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