The Clonogenic Cells of the Rat Mammary and Thyroid Glands: Their Biology, Frequency of Initiation, and Promotion/Progression to Cancer

  • Kelly H. Clifton


Quantitative transplantation and hormonal manipulation methods have been developed for studies of radiation carcinogenesis in the rat mammary and thyroid glands. Experiments with these systems have led to the conclusions a) that cancers are derived from small subpopulations of clonogenic cells in both organs, and b) that initiation, the first step in carcinogenesis, is a common event at the cellular level. It is postulated that any intracellular event which increases the probability of mutation in future rounds of cell division may serve as initiation. Several radiation-induced non-mutational intracellular processes are now recognized. In addition to mutation in growth-regulating genes, we suggest that the induction of one or more non-mutational processes may serve as initiation.


Thyroid Cell Clonogenic Cell Tracheal Epithelial Cell Graft Site Alveolar Unit 
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© Birkhäuser Boston 1990

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  • Kelly H. Clifton

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