Multiple Roles of the Calcium Ion in Cell Killing
The realization that the calcium ion is involved in the regulation of a large number of physiological processes has included the understanding that Ca2+ can play a determinant role in a variety of pathological and toxicological conditions. It has long been recognized that Ca2+ accumulates in necrotic tissue, and subsequent work has revealed that a disruption of intracellular Ca2+ homeostasis is frequently associated with the early development of cell injury (Fleckenstein et al., 1983; Jewell et al., 1982; Schanne et al., 1979). This led to the formulation of the calcium hypothesis of cell injury, which proposes that perturbation of the intracellular Ca2+ homeostasis may be a common step in the development of cytotoxicity.
KeywordsMercury Adenosine Glucocorticoid Cyanide Thiol
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