Biological Synthesis of Nitric Oxide from L-Arginine

  • John B. HibbsJr.
Part of the Advances in Research on Neurodegeneration book series (ARN, volume 2)


It has been observed that inorganic nitrogen oxides are enzymatically synthesized from L-arginine (Hibbs et al., 1987a, 1987b; Iyengar et al., 1987; Palmer et al., 1988) (Fig. 1). Nitric oxide (NO) appears to be the biologically active nitrogen oxide released from the various nitric oxide synthase isoforms. In 1988, two laboratories using different methodology demonstrated that NO- is released from cytokine and lipopolysaccharide-treated murine macrophages (Hibbs et al., 1988; Marietta et al., 1988). These experiments unequivocally established NO- as a low molecular weight biosynthetic product of mammalian cells.


Nitric Oxide Soluble Guanylate Cyclase Francisella Tularensis Muramyl Dipeptide Biological Synthesis 
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© Birkhäuser Boston 1994

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  • John B. HibbsJr.

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