Manganese-Induced Neurotoxicity

  • C. W. Olanow
  • D. B. Calne
  • N. S. Chu
  • D. P. Perl
Part of the Advances in Research on Neurodegeneration book series (ARN, volume 2)


Manganese is a paramagnetic heavy metal with an atomic number of 25 that was first recognized as an element by the Swedish chemist Schelle in 1771. It is the twelfth most common element in the earth’s crust and the fourth most widely used metal in the world. Eight million tons of manganese metal are extracted annually, of which 94% is employed in the manufacture of steel. Electrolytic high-temperature reduction converts manganese oxide to ferromanganese or silicomanganese (alloy) that contains approximately 70% manganese. Manganese dioxide is used in the manufacture of batteries. Potassium permanganate has bactericidal and fungicide properties and is extensively employed in water purification. In addition, the organic compound methylcyclopentadienyl manganese tricarbonyl (MMT) can be used in lieu of lead as an antiknock agent in gasoline.


Globus Pallidus Magnetic Resonance Imaging Change Manganese Toxicity Manganese Exposure Methylcyclopentadienyl Manganese Tricarbonyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Boston 1994

Authors and Affiliations

  • C. W. Olanow
  • D. B. Calne
  • N. S. Chu
  • D. P. Perl

There are no affiliations available

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