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Manganese-Induced Neurotoxicity

  • Chapter
Etiopathogenesis

Part of the book series: Advances in Research on Neurodegeneration ((ARN,volume 2))

Abstract

Manganese is a paramagnetic heavy metal with an atomic number of 25 that was first recognized as an element by the Swedish chemist Schelle in 1771. It is the twelfth most common element in the earth’s crust and the fourth most widely used metal in the world. Eight million tons of manganese metal are extracted annually, of which 94% is employed in the manufacture of steel. Electrolytic high-temperature reduction converts manganese oxide to ferromanganese or silicomanganese (alloy) that contains approximately 70% manganese. Manganese dioxide is used in the manufacture of batteries. Potassium permanganate has bactericidal and fungicide properties and is extensively employed in water purification. In addition, the organic compound methylcyclopentadienyl manganese tricarbonyl (MMT) can be used in lieu of lead as an antiknock agent in gasoline.

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References

  • Abd El, Naby S, Hassanein M (1965): Neuropsychiatric manifestations of chronic manganese poisoning. J Neurol Neurosurg Psychiatry 28:128–136

    Google Scholar 

  • Ashizawa R (1927): Über einen Sektionsfall von chronischer maganvergiftung. Jpn J Med Sci Trans Intern Med Pediatr Psychiatr 1:173–191

    Google Scholar 

  • Barbeau A (1984): Manganese and extrapyramidal disorders. Neurotoxicology 5:13–36

    PubMed  CAS  Google Scholar 

  • Bernheimer H, Birkmayer WA, Hornykiewicz O, Jellinger K, Scitelberger F (1967): Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological, and neurochemical correlations. J Neurol Sci 20:415–455

    Article  Google Scholar 

  • Bonilla E, Salazar E, Villasmil JJ, Villalobos R (1982): The regional distribution of manganese in the normal human brain. Neurochem Res 7:221–227

    Article  PubMed  CAS  Google Scholar 

  • Brouillet BP, Shinobu L, McGarvey U, Hochberg F, Beal MF: Manganese injection into the striatum produces excitotoxic lesions by impairing energy metabolism. Exp Neurol (in press)

    Google Scholar 

  • Calne DB, Snow BJ (1993): PET imaging in parkinsonism. In: Parkinson’s Disease: from Basic Research to Treatment. Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y, eds. Adv Neurol 60:484–487

    Google Scholar 

  • Canavan MM, Cobb S, Drinker CK (1934): Chronic manganese poisoning. Psychiatry 32:501–502

    Google Scholar 

  • Casamajor L (1913): An unusual form of mineral poisoning affecting the nervous system: manganese? JAMA 60:646–649

    Article  CAS  Google Scholar 

  • Cook DG, Fahn S, Brait KA (1974): Chronic manganese intoxication. Arch Neurol 30:59–64

    Article  PubMed  CAS  Google Scholar 

  • Cotzias C (1969): Metabolic modification of some neurologic disorders. JAMA 210:1255–1262

    Article  PubMed  CAS  Google Scholar 

  • Cotzias GC, Horiuchi K, Fuenzalida S, Mena I (1968): Chronic manganese poisoning: clearance of tissue manganese concentrations with persistence of the neurological picture. Neurology 18:647–651

    Article  Google Scholar 

  • Couper J (1837): On the effects of black oxide of manganese which inhaled into the lungs. Br Ann Med Pharm 1:41–42

    Google Scholar 

  • Daniels AJ, Abarca J (1991): Effect of intranigral Mn2+ on striatal and nigral synthesis and levels of dopamine and cofactor. Neurotoxicol Teratol 13:483–487

    Article  PubMed  CAS  Google Scholar 

  • Dastur DK, Manghani DK, Raghavendran KV, Jeejeebhoy KN (1968): Distribution and fate of the monkey: studies of different parts of the central nervous system and other organs. J Clin Invest 50:9–20

    Article  Google Scholar 

  • Donaldson J, Labella FS, Gesser D (1981): Enhanced autooxidation of dopamine as a possible basis of manganese neurotoxicity. Neurotoxicology 2:53–64

    PubMed  CAS  Google Scholar 

  • Drayer BP, Olanow W, Burger P, Johnson GA, Herfkens R, Riederer S (1986): Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. Radiology 159:493–498

    PubMed  CAS  Google Scholar 

  • Duvoisin R (1989): Is there a Parkinson’s disease? In: Disorders of Movement, Quinn NP, Jenner P, eds. Academic Press, London

    Google Scholar 

  • Edsall DL, Wilbur FP, Drinker CK (1919): The occurrence, course and prevention of chronic manganese poisoning. J Ihd Hyg 1:183–193

    CAS  Google Scholar 

  • Ejima A, Imamura T, Nakamura S, Saito H, Matsumoto K, Momono S (1992): Manganese intoxication during total parenteral nutrition. Lancet 339:426

    Article  PubMed  CAS  Google Scholar 

  • Emara AM, el-Ghawabi SH, Madkour OI, el-Samra GH (1971): Chronic manganese poisoning in the dry battery industry. Br J Ind Med 28: 78–82

    PubMed  CAS  Google Scholar 

  • Embden H (1901): Zur Kenntnis der metallischen nervengifte. Dtsch Med Wochenschr 27:795–796

    Article  Google Scholar 

  • Ferraz HB, Bertolucci PHG, Pereira JS, Lima JGC, Andrade LAF (1988): Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 38:550–553

    Article  PubMed  CAS  Google Scholar 

  • Flinn RH, Neal PA, Fulton WB (1941): Industrial manganese poisoning. J Ind Hyg Toxicol 23:374–387

    CAS  Google Scholar 

  • Gibb WRG, Lees AJ (1991): Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson’s disease. J Neurol Neurosurg Psychiatry 54:388–396

    Article  PubMed  CAS  Google Scholar 

  • Good PF, Olanow CW, Perl PP (1992): Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminium in Parkinson’s disease: a LAMMA study. Brain Res 593:343–346

    Article  PubMed  CAS  Google Scholar 

  • Greenhouse AH (1971): Manganese intoxication in the United States. Trans Am Neurol Assoc 96:248–249

    PubMed  CAS  Google Scholar 

  • Gutteridge JMC, Quinlan GJ, Clark I, Halliwell B (1985): Aluminum salts accelerate peroxidation of membrane lipids stimulated by iron salts. Biochem Biophys Acta 835:441–447

    Article  PubMed  CAS  Google Scholar 

  • Hassler R (1938): Zur Pathologie der Paralyse agitans und des postenzephalitischen Parkinsonism. J Psychol Neurol Leipzig 48:387–476

    Google Scholar 

  • Holzgraefe R, Poser W, Kijewski H, Beeuche W (1986): Chronic poisoning caused by potassium permanganate: a case report. Clin Toxicol 7:235–244

    Article  Google Scholar 

  • Huang C-C, Chu N-S, Lu C-S, Wang JD, Tsai JL, Tzeng JL, Wolters EC, Calne DB (1989): Chronic manganese intoxication. Arch Neurol 46:1104–1106

    Article  PubMed  CAS  Google Scholar 

  • Huang C-C, Lu C-S, Chu N-S, Hochberg F, Lienfeld D, Olanow CW, Calne DB (1993): Progression after chronic manganese exposure. Neurology 43:1479–1483

    Article  PubMed  CAS  Google Scholar 

  • Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992): Accuracy of clinical diagnosis of idiopathic Parkinson’s disease-pathologic study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184

    Article  PubMed  CAS  Google Scholar 

  • Larsen NA, Pakkenberg H, Damsgaard E, Heydorn K (1979): Topographical distribution of arsenic, manganese, and selenium in the normal human brain. J Neurol Sci 42:407–416

    Article  PubMed  CAS  Google Scholar 

  • Larsen NA, Pakkenberg H, Damsgaard E, Heydorn K, Wold S (1981): Distribution of arsenic, manganese and selenium in the human brain in chronic renal insufficiency, Parkinson’s disease, and amyotrophic lateral sclerosis. J Neurol Sci 51:437–446

    Article  PubMed  CAS  Google Scholar 

  • Lista A, Abarca J, Ramos C, Daniels AJ (1986): Rat striatal dopamine and tetrahydrobiopterin content following an intrastriatal injection of manganese chloride. Life Sci 38:2121–2127

    Article  PubMed  CAS  Google Scholar 

  • McGeer PL, Itagaki S, Akiyama H, McGeer EG (1989): Comparison of neuronal loss in Parkinson’s disease and aging. Adv Aging 36:25–34

    Google Scholar 

  • Mella H (1924): The experimental production of basal ganglion symptomatology in Macacus rhesus. Arch Neurol Psychiatry 11:405–417

    Google Scholar 

  • Mena I, Marin O, Fuenzalida S, Cotzias GC (1967): Chronic manganese poisoning. Clinical picture and manganese turnover. Neurology 17:128–136

    Article  PubMed  CAS  Google Scholar 

  • Mena I, Court J, Fuenzalida S, Papavasiliou PS, Cotzias GC (1970): Modification of chronic manganese poisoning. Treatment with L-dopa on 5-OH tryptophane. N Engl J Med 282:5–10

    Article  PubMed  CAS  Google Scholar 

  • Nelson K, Golnick J, Kom T, Angle C: Manganese encephalopathy: utility of early magnetic resonance imaging. Br J Ind Med (in press)

    Google Scholar 

  • Newland MC, Ceckler TL, Kordower JH, Weiss B (1989): Visualizing manganese in the primate basal ganglia with magnetic resonance imagining. Exp Neurol 106:251–258

    Article  PubMed  CAS  Google Scholar 

  • Olanow CW (1992): Magnetic resonance imaging in parkinsonism. Neurol Clin North Am 10:405–420

    CAS  Google Scholar 

  • Olanow CW, Alberts M, Djang W, Stajich J (1990): MR imaging of putaminal iron predicts response to dopaminergic therapy in parkinsonian patients. In: Early Markers in Parkinson’s and Alzheimer’s Diseases, Dostert P, Riederere P, Strolin B, et al., eds., pp. 99–109. Vienna: Springer-Verlag

    Chapter  Google Scholar 

  • Olanow CW, Calne DB, Perl D, Pate B (1993): Does manganese neurotoxicity act by way of iron-induced oxidant stress? Move Disord 8:410

    Article  Google Scholar 

  • Pakkenberg B, Moller A, Gundersen HJG, Dam AM, Pakkenberg H (1991): The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson’s disease estimated with an unbiased stereological method. J Neurol Neurosurg Psychiatry 54:30–33

    Article  PubMed  CAS  Google Scholar 

  • Parenti M, Rusconi L, Cappabianca V, Parati EA, Groppetti A (1988): Role of dopamine in manganese neurotoxicity. Brain Res 473:236–240

    Article  PubMed  CAS  Google Scholar 

  • Pate DB, McGeer EG, Kawamata, T, Yamada T, Snow BJ, Ruth TJ, Calne DB (1992): Neuron density in the SNC, and striatal dopamine, metabolite and synthetic enzyme levels in the unilateral MPTP-monkey SNC, model of parkinsonism. In: 2nd International Congress of Movement Disorders, Munich, Germany. Move Disord 7:154

    Google Scholar 

  • Pentschew A, Ebner FF, Kovatch RM (1963): Experimental manganese encephalopathy in monkeys. A preliminary report. J Neuropathol Exp Neurol 22:488–499

    Article  PubMed  CAS  Google Scholar 

  • Rinne UK, Laihinen A, Rinne JO, Någren K, Bergman J, Ruotsalainen U (1990): Positron emission tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson’s disease. Move Disord 5:55–59

    Article  CAS  Google Scholar 

  • Rajput AH, Uitti RJ, Sudhakar S, Rozdilsky B (1989): Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei. Ann Neurol 25:602–606

    Article  PubMed  CAS  Google Scholar 

  • Rodier J (1955): Manganese poisoning in Moroccan miners. Br J Ind Med 12:21–35

    PubMed  CAS  Google Scholar 

  • Rosenstock HA, Simons DG, Meyer JS (1971): Chronic manganism. Neurologic and laboratory studies during treatment with levodopa. JAMA 217:1354–1358

    Article  PubMed  CAS  Google Scholar 

  • Saric M, Markicervic A, Hrustic O (1979): Occupational exposure to manganese. Br J Ind Med 34:114–118

    Google Scholar 

  • Schüler P, Oyanguren H, Maturana V, Valenzuela A, Cruz E (1957): Manganese poisoning. Environmental and medical study at Chilean mine. Int Med Surg 26:167–173

    Google Scholar 

  • Smyth LT, Ruhf RC, Whitman NE, Dugan T (1973): Clinical manganism and exposure to manganese in the production and processing of ferromanganese alloy. J Occup Med 15:101–109

    PubMed  CAS  Google Scholar 

  • Suzuki Y, Mouri Y, Suzuki Y, Nishiyama K, Fujii N, Yano H (1975): Study of subacute toxicity of manganese dioxide in monkeys. Tokwshima J Exp Med 22:5–10

    CAS  Google Scholar 

  • Tanaka S, Lieben J (1969): Manganese poisoning and exposure in Pennsylvania. Arch Environ Health 19:674–684

    PubMed  CAS  Google Scholar 

  • von Jaksch R (1907): Über Mangantoxikosen und Manganophobie. Menchen Med Wochenschr 54:969–972

    Google Scholar 

  • Woltes ECH, Huang CC, Clark C, Peppard RF, Okada J, Chu NS, Adam MJ, Ruth TJ, Li D, Calne DE (1989): Positron emission tomography in manganese intoxication. Ann Neurol 26:647–651

    Article  Google Scholar 

  • Yamada M, Ohno S, Okayasu I, Okeda R, Hatakeyama S, Watanabe H, Ushio K, Tsukagoshi H (1986): Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain. Acta Neuropathol (Berl) 70:273–278

    Article  CAS  Google Scholar 

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Authors
  1. C. W. Olanow
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  2. D. B. Calne
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  3. N. S. Chu
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  4. D. P. Perl
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Editor information

Editors and Affiliations

  1. Department of Neurology, Juntendo University School of Medicine, Hongo, Bunkyo, Tokyo 113, Japan

    Yoshikuni Mizuno

  2. Neurodegenerative Disorders Center, The University of British Columbia, Purdy Pavillion, Vancouver, B.C., Canada, V6T 1W5

    Donald B. Calne (Director) (Director)

  3. Health Sciences Center, The Vancouver Hospital, 2211 Wesbrook Mall, Vancouver, B.C., Canada, V6T 1W5

    Donald B. Calne (Director) (Director)

  4. Clinical Research, Special Research Projects, Schering AG Berlin, Müllerstraße 170-178, D-1000, Berlin 65, Germany

    R. Horowski

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© 1994 Birkhäuser Boston

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Olanow, C.W., Calne, D.B., Chu, N.S., Perl, D.P. (1994). Manganese-Induced Neurotoxicity. In: Mizuno, Y., Calne, D.B., Horowski, R. (eds) Etiopathogenesis. Advances in Research on Neurodegeneration, vol 2. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4684-9203-3_6

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  • DOI: https://doi.org/10.1007/978-1-4684-9203-3_6

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4684-9205-7

  • Online ISBN: 978-1-4684-9203-3

  • eBook Packages: Springer Book Archive

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