Discussion: Session 8 — 9 A.M. - 8 February 1993
After George-Hyslop’s presentation CaIne pointed out that genetic heterogeneity in Alzheimer’s disease obviously corresponds to clinical heterogeneity. Specifically he wondered how many cases of Alzheimer’s disease would fall into the category of genetically determined familial Alzheimer’s disease, how many were sporadic cases predominantly caused by environmental factors, and how many cases would fall in between these categories. George-Hyslop thought that “pure” genetic cases of Alzheimer’s disease were extremely rare and that the majority are probably caused by an interaction of genetic and environmental factors.
KeywordsSubstantia Nigra Molecular Weight Form Growth Factor Therapy Premorbid Personality Parkinsonian Substantia Nigra
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