Neuroepidemiology of Parkinson’s Disease: Environmental Influences

  • William C. Koller
Part of the Advances in Research on Neurodegeneration book series (ARN, volume 2)


Descriptive epidemiology of Parkinson’s disease (PD), by providing a profile of the disease, should be useful in the etiological investigation of PD. Etiological hypotheses need to be consistent with known epidemiologic factors, and descriptive epidemiologic observations may generate a new hypothesis. Analytic epidemiology seeks to identify risk factors that could lead to clues for causal associations with the disease.


Essential Tremor Rural Living Environmental Toxin Cycad Plant Childhood Measle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Aquilonius SM, Hartvig P (1986): A Swedish county with unexpectedly high utilization of anti-parkinsonian drugs. Acta Neurol Scand74:379PubMedCrossRefGoogle Scholar
  2. Ashok PP, Radhakrishnan K, Sridharan R, Mousa ME (1986): Epidemiology of Parkinson’s disease in Benghazi, north-east Libya. Neurosurgery88(2): 109–113Google Scholar
  3. Bademosi O, Al-Rajeh IH, Awada A (1991): Prevalence of Parkinson’s disease (PD) in an Arab community: the Thugbah study. In: Congres de neurologie tropicale, September 26–28, 1991, p. 27. Recherche en Neurologic Tropicale PressGoogle Scholar
  4. Barbeau A, Roy M (1985): Uneven prevalence of Parkinson’s disease in the province of Quebec. Can J Neurol Sci12:169–170Google Scholar
  5. Barbeau A, Roy M, Bernier G, et al. (1987): Ecogenetics of Parkinson’s disease: prevalence and environmental aspects in rural areas. Can J Neurol Sci14:36–41PubMedGoogle Scholar
  6. Baumann RJ, Jamesson HD, McKean HE, Haack DG, Weisburg LM (1980): Cigarette smoking and Parkinson’s disease. I. A comparison of cases with matched neighbors. Neurology30:839PubMedCrossRefGoogle Scholar
  7. Bharucha NE, Bharucha EP, Bharucha AE, Bhise AV, Schoenberg BS (1988): Prevalence of Parkinson’s disease in the Parsi community in Bombay, India. Arch Neurol45:1321–1323PubMedCrossRefGoogle Scholar
  8. Bodmer WF (1973): Population genetics of the HLA system: retrospect and prospect. In: Histocompatibility Testing 1972, Dausset J, Colombani J, eds., pp. 611–667. Copenhagen: MunksgaardGoogle Scholar
  9. Brewis M, Poskanzer DC, Rolland C, Miller H (1966): Neurological disease in an English city. Acta Neurol Scand42(Suppl 24): 1–89PubMedGoogle Scholar
  10. Broman T (1963): Parkinson’s syndrome, prevalence and incidence in Goteborg. Acta Neurol Scand51 (Suppl 4):95–101Google Scholar
  11. Burch PRJ (1981): Cigarette smoking and Parkinson’s disease. Neurology31:500.PubMedGoogle Scholar
  12. Burns SP, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ (1983): A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA80:4546–4550PubMedCrossRefGoogle Scholar
  13. Calne DB, Langston JW (1983): Aetiology of Parkinson’s disease. Lancet2:1457–1459PubMedCrossRefGoogle Scholar
  14. Casetta I, Granieri E, Govoni V, et al. (1990): Epidemiology of Parkinson’s disease in Italy. A descriptive survey in the U.S.L. of Cento, province of Ferrara, Emilia-Romagna. Acta Neurol(Napoli) 12:284–291Google Scholar
  15. Clifford WB, Heaton TB, Voss PR, Fuguitt GV (1985): The rural elderly in demographic perspective. In: The Elderly in Rural Society: Every Fourth Elder, Coward RT, Lee GR, eds., pp. 25–55. New York: SpringerGoogle Scholar
  16. D’Alessandro R, Gamberini G, Granieri E, Benassi G, Naccarato S, Manzaroli D (1987): Prevalence of Parkinson’s disease in the Republic of San Marino. Neurology37:1679–1682PubMedCrossRefGoogle Scholar
  17. Dupont E (1977): Epidemiology of parkinsonism. The Parkinson investigation, Arhus, Denmark (preliminary results). In: Symposium on Parkinsonism, Worm-Peterson J, Bottcher J, eds., pp. 65–75. Denmark: Merck, Sharp & DohmeGoogle Scholar
  18. Golbe LI, Farrell T (1988): Case-control survey of early-adult dietary habits in Parkinson’s disease. Neurology38(Suppl 1):204Google Scholar
  19. Granieri E, Carreras M, Casetta I, et al. (1991): Parkinson’s disease in Ferrara, Italy, 1967 through 1987. Arch Neurol48:854–857PubMedCrossRefGoogle Scholar
  20. Gudmundsson KR (1967): A clinical survey of parkinsonism in Iceland. Acta Neurol Scand43(Suppl) 33:1–61Google Scholar
  21. Harado H, Nishikawa S, Takahashi K (1983): Epidemiology of Parkinson’s disease in a Japanese city. Arch Neurol40:151–154CrossRefGoogle Scholar
  22. Ho SC, Woo J, See CM (1989): Epidemiologic study of Parkinson’s disease in Hong Kong. Neurology39:1314–1318PubMedCrossRefGoogle Scholar
  23. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992): The accuracy of the clinical diagnosis of Parkinson’s disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry55:181–184PubMedCrossRefGoogle Scholar
  24. Jannson B, Jankovic J (1985): Low cancer rates among patients with Parkinson’s disease. Ann Neurol17:505CrossRefGoogle Scholar
  25. Jenkins AC (1966): Epidemiology of parkinsonism in Victoria. Med J Aust2:496–502PubMedGoogle Scholar
  26. Jenner P, Marsden CD (1988): MPTP-induced parkinsonism in primates and its use in the assessment of novel strategies for the treatment of Parkinson’s disease. In: Current Problems in Neurology (6): Parkinson’s Disease: Clinical and Experimental Advances, Rose FC, ed., pp. 149–162. London: John LibbeyGoogle Scholar
  27. Jimenez-Jimenez FJ, Gonzales DM, Gimrnez-Roldan S (1988): Exposure to well water drinking and pesticides in Parkinson’s disease. In: Proceedings of the Ninth International Symposium on Parkinson’s Disease, p. 118, World Congress of Neurology, JerusalemGoogle Scholar
  28. Kessler II (1972): Epidemiologic studies of Parkinson’s disease. A hospital-based survey. Am J Epidemiol95:308–318PubMedGoogle Scholar
  29. Kessler II (1973): Parkinson’s disease: perspectives on epidemiology and pathogenesis. Prev Med2:88–105PubMedCrossRefGoogle Scholar
  30. Koller WC (1983): Alcoholism in essential tremor. Neurology33:1074PubMedCrossRefGoogle Scholar
  31. Koller WC (1992): When does Parkinson’s disease begin? Neurology43(Suppl 4):27–31Google Scholar
  32. Koller WC, Vetere-Overfield B, Gray C, Alexander C, Chin T, Dolezal, Hassanein R, Tanner C (1990): Environmental risk factors in Parkinson’s disease. Neurology40: 1218–1221PubMedCrossRefGoogle Scholar
  33. Kurland LT (1958): Epidemiology: incidence, geographic distribution and genetic considerations. In: Pathogenesis and Treatment of Parkinsonism, Field WS, ed., pp. 5–49. Springfield, IL: Charles C. ThomasGoogle Scholar
  34. Kurtzke JF, Murphy FM (1990): The changing patterns of death rates in parkinsonism. Neurology40:42–49PubMedCrossRefGoogle Scholar
  35. Langston JW, Langston EB, Irwin I (1984a): MPTP-induced parkinsonism in human and non-human primates. Clinical and experimental aspects. Acta Neurol Scand70:49–54Google Scholar
  36. Langston JW, Forno LS, Rebert CS, Irwin (1984b): Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the squirrel monkey. Brain Res292:390–394PubMedCrossRefGoogle Scholar
  37. Li SC, Schoenberg BS, Wang CC, et al. (1985): A prevalence survey of Parkinson’s disease and other movement disorders in the People’s Republic of China. Arch Neurol42:655–657PubMedCrossRefGoogle Scholar
  38. Marmot M (1981): Mortality and Parkinson’s disease. In: Research Progress in Parkinson’s Disease 1980, Rose F, Capildeo R, eds. pp. 9–16. Kent: Tunbridge WellsGoogle Scholar
  39. Marttila RJ, Rinne U (1976): Epidemiology of Parkinson’s disease in Finland. Acta Neurol Scand53:81–102PubMedCrossRefGoogle Scholar
  40. Meador KJ, Meador MP, Loring DS, et al. (1987): Neuroepidemiology of Parkinson’s disease. Neurology37(Suppl 1): 120Google Scholar
  41. Mitchell IJ, Cross AJ, Sambrook MA, Crossman AR (1985): Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus. Neurosci Lett61:195–200PubMedCrossRefGoogle Scholar
  42. Morgante L, Racco WA, Rosa AE (1992): Prevalence of Parkinson’s disease and other types of parkinsonism: a door-to-door survey in three Sicilian municipalities. Neurology42: 1901–1906PubMedCrossRefGoogle Scholar
  43. Nobrega FT, Glattre E, Kurland LT, Okazaki H (1969): Comments on the epidemiology of parkinsonism including prevalence and incidence statistics for Rochester, Minnesota, 1935–1936. In: Progress in Neuro-Genetics: Proceedings of the International Congress of Neuro-Genetics, Barbeau A, Brunette JS, eds., pp. 474–485. Amsterdam: Excerpta MedicaGoogle Scholar
  44. Okada K, Kobayashi S, Tsunematsu T (1990): Prevalence of Parkinson’s disease in Izumo City, Japan. Gerontology36:340–344PubMedCrossRefGoogle Scholar
  45. Rajput AH, Stern W, Christ A, Laverty W (1984a): Etiology of Parkinson’s disease: environmental factor(s). Neurology34(Suppl 1):207Google Scholar
  46. Rajput AH, Offurd KP, Beard CM, Kurland LT (1984b): Epidemiology of parkinsonism: incidence, classification, and mortality. Ann Neurol16:278–282PubMedCrossRefGoogle Scholar
  47. Rajput AH, Offurd KP, Beard CM, Kurland LT (1984c): A case-control study of smoking habits, dementia, and other illnesses in idiopathic Parkinson’s disease. Neurology37:226CrossRefGoogle Scholar
  48. Rajput AH, Uitti RJ, Stern W, et al. (1987b): Geography, drinking water chemistry, pesticides, and herbicides and the etiology of Parkinson’s disease. Can J Neurol Sci14:414PubMedGoogle Scholar
  49. Rajput AH, Uitti RJ, Stern W, et al. (1986): Early onset Parkinson’s disease in Saskatchewan: environmental considerations for etiology. Can J Neurol Sci13:212–216Google Scholar
  50. Rosati G, Granieri E, Pinna L, et al. (1978): Parkinson’s disease. Prevalence and incidence in the province of Sassari, North Sardinia. Acta Neurol(Napoli) 33:210–207Google Scholar
  51. Rosati G, Granieri E, Pinna L, Devoto MC (1979): The frequency of Parkinson’s disease in the province of Nuoro (Sardinia). Acta Neurol1:303–308Google Scholar
  52. Rosati G, Granieri E, Pinna L, et al. (1980): The risk of Parkinson’s disease in Mediterranean people. Neurology30:250–255PubMedCrossRefGoogle Scholar
  53. Sasco AJ, Paffenberger RS, Jr (1985): Measles infection and Parkinson’s disease. Am J Epidemiol122:1017PubMedGoogle Scholar
  54. Schoenberg BS, Anderson DW, Haerer AF (1985): Prevalence of Parkinson’s disease in the biracial population of Copiah County, Mississippi. Neurology35:841–845PubMedCrossRefGoogle Scholar
  55. Schoenberg BS, Osuntokun BO, Adeuja AO, et al. (1988): Comparison of the prevalence of Parkinson’s disease in black populations in the rural United States and rural Nigeria: door-to-door community studies. Neurology38:645–646PubMedCrossRefGoogle Scholar
  56. Semchuck KM, Love EJ, Lee RG (1991): Parkinson’s disease and exposure to rural environmental factors: a population based case-control study. Can J Neurol Sci18:279–386Google Scholar
  57. Snow B, Wiens M, Hertzman C, Calne DB (1989): A community survey of Parkinson’s disease. Can Med Assoc141:418–422Google Scholar
  58. Spencer PS, Kisby GE, Ludopha AC (1991): Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region. Neurology41(Suppl 2):62–66PubMedCrossRefGoogle Scholar
  59. Steventon GB, Heafield MTE, Waring RH, Williams AC (1989): Xenobiotic metabolism in Parkinson’s disease. Neurology39:883–887PubMedCrossRefGoogle Scholar
  60. Tanner CM, Chen B, Wang WZ, et al. (1987): Environmental factors in the etiology of Parkinson’s disease. Can J Neurol Sci14:419PubMedGoogle Scholar
  61. Tanner CM, Cohen JC, Summerville BC, Goetz CG (1988): Vitamin use and Parkinson’s disease. Ann Neurol233:182Google Scholar
  62. Teräväinen H, Forgach L, Hietanen M, Schulzer M, Schoenberg BS, Calne DB (1986): The age of onset of Parkinson’s disease, etiologic implications. Can J Neurol Sci13:317PubMedGoogle Scholar
  63. Tetrud JW, Langston JW (1987): L-Deprenyl as a possible protective agent in Parkinson’s disease. J Neural transm25:69–79Google Scholar
  64. Wang Y, Shi Y, Wu S, He Y, Zhang B (1991): Parkinson’s disease in China. Chin Med J33:960–964Google Scholar
  65. Waring RH, Sturman SG, Smith MCG, Steventon GB, Heafield MTE, Williams AC (1989): S-Methylation in motor neuron disease and Parkinson’s disease. Lancet2:356–357PubMedCrossRefGoogle Scholar
  66. Wender M, Pruchnik D, Kowal P, Florczak J, Zalejski M (1989): Epidemiology of Parkinson’s disease in the Pozna’n province. Przegl Epidemiol43:150–155PubMedGoogle Scholar

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© Birkhäuser Boston 1994

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  • William C. Koller

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