Centrally Mediated Cardiovascular Effects of Taurine

  • Katsuyuki Ando
  • Toshiro Fujita


Taurine, which is synthesized from methionine in vivo, is a sulfur amino acid widely distributed in mammalian tissues, especially in brain, heart, and skeletal muscle. Taurine has been extensively studied for its cardiovascular actions. In stroke-prone spontaneously hypertensive rats (SHRSP) (Nara et al., 1978), spontaneously hypertensive rats (SHR) (Abe et al., 1987), and deoxycorticosterone acetate (DOCA)-salt hypertensive rats (Fujita and Sato, 1986; Inoue et al., 1988), the administration of taurine could attenuate the development of hypertension (Fig. 5.1). The antihypertensive effect of taurine is most pronounced in a salt-induced hypertensive model associated with increased sympathetic activity (Bouvier and de Champlain, 1986; Sato et al., 1991), such as the DOCA-salt rat (Fujita and Sato, 1986; Inoue et al., 1988). In addition, taurine has other cardiovascular actions, such as negative inotropic and positive chronotropic effects on heart (Huxtable and Sebring, 1982).


Cold Exposure Sympathetic Nerve Activity Sympathetic Nervous System Activity Sulfur Amino Acid Endogenous Opioid Peptide 
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© Birkhäuser Boston 1992

Authors and Affiliations

  • Katsuyuki Ando
  • Toshiro Fujita

There are no affiliations available

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