Modifications of the Phase Transitions of Model Membranes by Exogen Molecules

  • G. Albertini
  • M. G. Ponzi-Bossi
  • F. Rustichelli
Part of the NATO ASI Series book series (NSSB, volume 290)


This Chapter discusses the interaction of model membranes, which are organized as lamellar lyotropic liquid crystal phases, with exogen molecules such as cholesterol, anaesthetics, drugs and aminoacids.


Differential Scanning Calorimetry Main Transition Model Membrane Azelaic Acid Lamellar Phase 
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  1. 1.
    G.H. Brown and J.J. Wolken, “Liquid Crystals and Biological Structures,” Academic Press, NY (1979).Google Scholar
  2. 2.
    V. Luzzati and A. Tardieu, Ann. Rev. Phis. Chem. 25:79 (1974).ADSCrossRefGoogle Scholar
  3. 3.
    S.J. Singer and G.L. Nicolson, Science 175:720 (1972).ADSCrossRefGoogle Scholar
  4. 4.
    D. Chapman, in “Biological Membranes”, D. Chapman and D. H. F. Wallach, eds., Academic Press, N.Y., 2: 91 (1973).Google Scholar
  5. 5.
    J. Stumpel, H. Eibel, and A. Nicksch, Biochim. Biophys. Acta 727: 246 (1983).CrossRefGoogle Scholar
  6. 6.
    V. Luzzati, in “Biological Membranes”, D. Chapman, ed., Academic Press, NY, p. 71 (1968).Google Scholar
  7. 7.
    M.J. Janiak, D.M. Small and G.G. Shipley, J. Biol. Chem. 254:6068 (1979).Google Scholar
  8. 8.
    M.J. Janiak, D.M. Small and G.G. Shipley, Biochemistry 15:4575 (1976).CrossRefGoogle Scholar
  9. 9.
    A. Watts, K. Harlos and D. Marsh, Biochim. Biophys. Acta 645: 91 (1981).CrossRefGoogle Scholar
  10. 10.
    N. P. Franks, J. Mol. Biol. 100: 345 (1976).CrossRefGoogle Scholar
  11. 11.
    G. Albertini, A. Ambrosini, B. Dubini M.G. Ponzi-Bossi and G. Bossi, Il Nuovo Cimento 12D9:1309(1990).ADSCrossRefGoogle Scholar
  12. 12.
    A. Tardieu, V. Luzzati and F.C. Reman, J. Mol. Biol. 75:711 (1973).CrossRefGoogle Scholar
  13. 13.
    G. Albertini, G. Bossi, B. Dubini, M.G. Ponzi-Bossi and F. Rustichelli, Il Nuovo Cimento 10D: 1385 (1988).ADSCrossRefGoogle Scholar
  14. 14.
    J. Stumpel, H. Eibl and A. Nicksch, Biochim. et Biophys. Acta 727: 246 (1983).CrossRefGoogle Scholar
  15. 15.
    J. J. Benattar, F. Moussa and M. Lambert, J. Phys. (Paris) 44: 1371 (1980).Google Scholar
  16. 16.
    J. J. Benattar, F. Moussa, M. Lambert and C. Germain, J. Phys. (Paris). Lett. 12: 67 (1981).CrossRefGoogle Scholar
  17. 17.
    G. Albertini, E. Fanelli, S. Melone, F. Rustichelli and G. Torquati, Solid State Commun. 49: 1143 (1984).ADSCrossRefGoogle Scholar
  18. 18.
    G. Albertini, S. Melone, G. Poeti, F. Rustichelli and G. Torquati, Mol. Cryst. Liq. Cryst. 101: 121 (1984).CrossRefGoogle Scholar
  19. 19.
    T. J. Mcintosh, Biochim. et Biophys. Acta 513: 43 (1978).CrossRefGoogle Scholar
  20. 20.
    B.R. Lentz, D.A. Barrow and M. Hoechli, Biochemistry, 19: 1943 (1980).CrossRefGoogle Scholar
  21. 21.
    W. Knoll, G. Schmidt, K. Ibel and E. Sackmann, Biochemistry 24: 5240 (1985).CrossRefGoogle Scholar
  22. 22.
    G. Albertini, G. Bossi, B. Dubini, M.G. Ponzi-Bossi and F. Rustichelli, Mol. Cryst Liq. Cryst 179: 383 (1990).Google Scholar
  23. 23.
    G. Albertini, A. Ambrosini, V. Baldassarre, F. Rustichelli, P.L. Sapelli and R. Sconocchia, Stomat Lomb., anno I, 2: 59 (1987).Google Scholar
  24. 24.
    C. Gobbi, “Effettistrutturali e termodinamici dell’anestetico locale xilocaina su membrane modellodi lecitina”. Thesis, University of Ancona, 1988.Google Scholar
  25. 25.
    M.B. Feinstein, Journal of General Physiology, 48: 357 (1964).CrossRefGoogle Scholar
  26. 26.
    P.R. Cullis, A.P. Hornby and M.J. Hope, in “Progress in Anesthesiology,” B. Raymond Fink, ed., Raven Press, New York (1980).Google Scholar
  27. 27.
    K. H. Meyer, Trans. Faraday Soc., 33: 1062 (1937).CrossRefGoogle Scholar
  28. 28.
    P. Seeman, Pharmacol. Rev., 24: 583 (1972).Google Scholar
  29. 29.
    J. Stumphel, H. Eibl and A. Nicksch, Biochimica et Biophysica Acta, 727: 246 (1983).CrossRefGoogle Scholar
  30. 30.
    M.J. Janiak, D.M. Small and G.G. Shipley, Biochemistry, 21, 15: 4575 (1976).Google Scholar
  31. 31.
    “Drug Treatment Principles and Practice of Clinical Pharmacology and Therapeutic,” G. S. Avery, ed., Adis Press, Churchill Livingston, 2nd edition (1980).Google Scholar
  32. 32.
    D.T. Mason, A.N. De Maria, R. Amsterdam, R. Zelis and R.A. Massumi, Drugs, 5: 261 (1973).CrossRefGoogle Scholar
  33. 33.
    B.N. Singh, Drugs, 15:218 (1978).CrossRefGoogle Scholar
  34. 34.
    G. Johnson and C.G. Regardh, Clinical Pharmacokinetics, 1: 233 (1976).CrossRefGoogle Scholar
  35. 35.
    A. Bienvenue and J. Philippot, in “Les liposomes applications therapeutiques,” Ed. F. Puisieux and J. Delatbre, Paris, p.149 (1985).Google Scholar
  36. 36.
    N. Dousset and L. Douste-Blazy, in “Les liposomes applications therapeutiques”, Ed. F. Puisieux and J. Delatbre, Paris, p.41 (1985).Google Scholar
  37. 37.
    G. Albertini, C. Donati, F. Rustichelli and R.S. Phadke, Il Nuovo Cimento, 10D 11: 1399 (1988).CrossRefGoogle Scholar
  38. 38.
    G. Albertini, C. Donati, R.S. Phadke, M.G. Ponzi-Bossi and F. Rustichelli, Chemistry of Physics and Lipids, 55:331(1990).CrossRefGoogle Scholar
  39. 39.
    L.E.G. Eriksson, Biophys. Chem. 26: 9 (1987).CrossRefGoogle Scholar
  40. 40.
    D. Small, in “The Physical Chemistry of Lipids,” D.J. Hanahan, ed., Plenum Press, New York, N.Y. Chapt.8 (1986).Google Scholar
  41. 41.
    S. Passi, M. Picardo, G. Mingrone, A. Brethnach and M. Nazzaro-Porro, Acta Derm. Venereol., Suppl. 143: 8 (1987).Google Scholar
  42. 42.
    K.U. Schallreuter, M.R. Pittelkow and J.M. Wood, J. Invest. Dermatol., 88: 516 (1987).Google Scholar
  43. 43.
    M. Nazzaro-Porro and S. Passi, G. Ital. Dermatol., 113:401 (1978).Google Scholar
  44. 44.
    M. Nazzaro-Porro, S. Passi, L. Balus, A.S. Breathnach, B. Martin and G. Morpurgo, J. Invest. Dermatol. 72: 296(1979).CrossRefGoogle Scholar
  45. 45.
    M. Nazzaro-Porro, S. Passi, G. Zina, A. Bernengo, A.S. Breathnach, S. Gallagher and G. Morpurgo, Lancet, 109 (1980).Google Scholar
  46. 46.
    A. Mayer Da Silva, H. Gollnick, M. Detmar, J. Gassmuller, A. Parry, R. Muller and C.E. Orfanos, Acta Derm. Venereol., Suppl. 143:20 (1987).Google Scholar
  47. 47.
    A.S. Breathnach, E.J. Robins, M. NazzaroPorro, S. Passi and M. Picardo, Acta Derm. Venereol., Suppl. 143: 62 (1987).Google Scholar
  48. 48.
    M. Nazzaro-Porro, S. Passi, M. Picardo, R. Mercantini and A.S. Breathnach, J. Invest. Dermatol 87: 108 (1986).CrossRefGoogle Scholar
  49. 49.
    G. Bossi, B. Dubini, P. Mariani, M.G. Ponzi-Bossi, F. Rustichelli and R.S. Phadke, Il Nuovo Cimento 12D 9:1293 (1990).ADSCrossRefGoogle Scholar
  50. 50.
    R.C. Chaatelier, P.S. Rogers, K.P. Ghiggino and W.H. Saawyer, Biochem. Biophys. Acta 776: 75 (1984).CrossRefGoogle Scholar
  51. 51.
    S.S. Lehrer in: R.F. Chen and H. Edelhoc (Eds), Biochemical Fluorescence Concepts, Vol.2 Marcel Dekker, New York 515, (1976).Google Scholar
  52. 52.
    C.T.A. Aquaye, M. Wilcheck and M. Goreki, Biochem. Int. 4: 221 (1982)Google Scholar
  53. 53.
    J. Kumpati, Biophys. Res. Commun. 105:482 (1982).CrossRefGoogle Scholar
  54. 54.
    G. Albertini, E. Bertoli, G. Curatola, P. Mariani, F. Rustichelli and G. Zolese, Chemistry and Physics of Lipids, 50: 143 (1989).CrossRefGoogle Scholar
  55. 55.
    P. Mariani, A. Colotto and G. Albertini, Chemistry and Physics of Lipids, 55: 283 (1990).CrossRefGoogle Scholar
  56. 56.
    M.C. Block, L.L. Van Deenen and J. De Gier, Biochim. Biophys. Acta, 433:420 (1976).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • G. Albertini
    • 1
  • M. G. Ponzi-Bossi
    • 2
  • F. Rustichelli
    • 1
  1. 1.Dipartimento di Scienze dei Materiali e della TerraUniversità di AnconaItaly
  2. 2.Istituto di Fisica Medica, Facoltà di Medicina e ChirurgiaUniversità di AnconaItaly

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